Discovery, Biological Evaluation, and Structure–Activity and −Selectivity Relationships of 6′-Substituted (E)‑2-(Benzofuran-3(2H)‑ylidene)‑N‑methylacetamides, a Novel Class of Potent and Selective Monoamine Oxidase Inhibitors

The use of selective inhibitors of monoamine oxidase A (MAO-A) and B (MAO-B) holds a therapeutic relevance in the treatment of depressive disorders and Parkinson’s disease (PD), respectively. Here, the discovery of a new class of compounds acting as monoamine oxidase inhibitors (MAO-Is) and bearing...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-03, Vol.56 (6), p.2651-2664
Hauptverfasser:	Pisani, Leonardo, Barletta, Maria, Soto-Otero, Ramon, Nicolotti, Orazio, Mendez-Alvarez, Estefania, Catto, Marco, Introcaso, Antonellina, Stefanachi, Angela, Cellamare, Saverio, Altomare, Cosimo, Carotti, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzofurans - chemistry Benzofurans - metabolism Benzofurans - pharmacology Drug Discovery Humans Molecular Docking Simulation Monoamine Oxidase - chemistry Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - chemistry Monoamine Oxidase Inhibitors - metabolism Monoamine Oxidase Inhibitors - pharmacology Protein Conformation Stereoisomerism Structure-Activity Relationship
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