Large decrease of anti-tetanus anatoxin and anti-pneumococcal antibodies at one year after renal transplantation

In kidney transplant recipients (KTR), antibody (Ab) synthesis is hampered by AZA and CsA. We here report in a prospective cohort study, the effects of mycophenolate mofetil (MMF) associated to a calcineurin inhibitor on plasma levels of anti-tetanus anatoxin Ab (TAnAb) and anti-pneumococcal Ab (PnP...

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Veröffentlicht in:Clinical nephrology 2013-04, Vol.79 (4), p.313-317
Hauptverfasser: Broeders, Emine Nilufer, Wissing, Karl M, Ghisdal, Lidia, Lemy, Anne, Hoang, Anh-Dung, Vereerstraeten, Pierre, Mascart, Françoise, Abramowicz, Daniel
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container_end_page 317
container_issue 4
container_start_page 313
container_title Clinical nephrology
container_volume 79
creator Broeders, Emine Nilufer
Wissing, Karl M
Ghisdal, Lidia
Lemy, Anne
Hoang, Anh-Dung
Vereerstraeten, Pierre
Mascart, Françoise
Abramowicz, Daniel
description In kidney transplant recipients (KTR), antibody (Ab) synthesis is hampered by AZA and CsA. We here report in a prospective cohort study, the effects of mycophenolate mofetil (MMF) associated to a calcineurin inhibitor on plasma levels of anti-tetanus anatoxin Ab (TAnAb) and anti-pneumococcal Ab (PnPsAb). Serum titers of the TAnAb and the PnPsAb against serotypes 14, 19F and 23F were measured in 94 KTR on Day 0 (T0) and 1 year (T12) after renal transplantation and in 49 healthy controls. 1) At T0, TAnAb were detected in only 71% of patients vs. 98% of controls (p < 0.0001) and the titers were significantly lower in KTR (1.46 UI/ml vs. 2.74 in controls, p = 0.01); they further decreased between T0 and T12 (1.46 UI/ml to 0.31, p < 0.0001). The calculated half-life (t1/2) of TAnAb was 7.7 months, as compared to more than 10 years in a normal population. 2) In KTR, PnPsAb titers decreased significantly between T0 and T12 (p < 0.005); the t1/2 of the different PnPsAb ranged from 9.2 to 11.9 months. In KTR treated by MMF and CNI, the TAnAbs and PnPsAbs titers decrease significantly and profoundly during the first year. Immunization pre-transplantation should be encouraged to maintain adequate post-transplant Abs levels.
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subjects Adult
Antibodies, Bacterial - blood
Antibody Formation - drug effects
Calcineurin Inhibitors
Case-Control Studies
Cyclosporine - adverse effects
Down-Regulation
Drug Therapy, Combination
Enzyme-Linked Immunosorbent Assay
Female
Half-Life
Humans
Immunization
Immunosuppressive Agents - adverse effects
Kidney Transplantation - immunology
Male
Middle Aged
Mycophenolic Acid - adverse effects
Mycophenolic Acid - analogs & derivatives
Pneumococcal Vaccines - immunology
Prospective Studies
Tacrolimus - adverse effects
Tetanus Toxoid - immunology
Time Factors
Treatment Outcome
title Large decrease of anti-tetanus anatoxin and anti-pneumococcal antibodies at one year after renal transplantation
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