Allopregnanolone and Pregnanolone Analogues Modified in the C Ring: Synthesis and Activity

(25R)-3β-Hydroxy-5α-spirostan-12-one (hecogenin) and 11α-hydroxypregn-4-ene-3,20-dione (11α-hydroxyprogesterone) were used as starting materials for the synthesis of a series of 11- and 12-substituted derivatives of 5ξ-pregnanolone (3α-hydroxy-5α-pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one), the...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-03, Vol.56 (6), p.2323-2336
Hauptverfasser:	Slavíková, Barbora, Bujons, Jordi, Matyáš, Libor, Vidal, Miguel, Babot, Zoila, Krištofíková, Zdena, Suñol, Cristina, Kasal, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemistry Techniques, Synthetic Mice Models, Molecular Neurons - metabolism Pregnanolone - analogs & derivatives Pregnanolone - chemical synthesis Pregnanolone - metabolism Protein Conformation Quantitative Structure-Activity Relationship Receptors, GABA-A - chemistry Receptors, GABA-A - metabolism
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