IL-20, IL-21 and p40: potential biomarkers of treatment response for ustekinumab

Although biological drugs in psoriasis treatment show clinical efficacy, there are still a proportion of patients in whom little treatment response is obtained. The aim of this study was to identify molecular biomarkers for treatment response and to investigate the molecular effects of ustekinumab t...

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Veröffentlicht in:	Acta dermato-venereologica 2013-03, Vol.93 (2), p.150-155
Hauptverfasser:	Gedebjerg, Anne, Johansen, Claus, Kragballe, Knud, Iversen, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - therapeutic use Biological Products - therapeutic use Biopsy Genetic Markers Genotype Humans Interleukin-12 Subunit p40 - genetics Interleukins - genetics Phenotype Psoriasis - diagnosis Psoriasis - drug therapy Psoriasis - genetics Psoriasis - immunology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Severity of Illness Index Skin - immunology Skin - pathology Time Factors Treatment Outcome Up-Regulation Ustekinumab
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