Longitudinal compression of the platinum-chromium everolimus-eluting stent during coronary implantation: Predisposing mechanical properties, incidence, and predictors in a large patient cohort

Objectives: To assess the longitudinal compression behavior of platinum‐chromium everolimus‐eluting stents, evaluate frequency of inadvertent longitudinal compression during percutaneous intervention, and define patient‐ and lesion‐related predictors of this complication. Background: Platinum‐chromi...

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Veröffentlicht in:Catheterization and cardiovascular interventions 2013-04, Vol.81 (5), p.E206-E214
Hauptverfasser: Leibundgut, Gregor, Gick, Michael, Toma, Aurel, Valina, Christian, Löffelhardt, Nikolaus, Joachim Büttner, Heinz, Neumann, Franz-Josef
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container_end_page E214
container_issue 5
container_start_page E206
container_title Catheterization and cardiovascular interventions
container_volume 81
creator Leibundgut, Gregor
Gick, Michael
Toma, Aurel
Valina, Christian
Löffelhardt, Nikolaus
Joachim Büttner, Heinz
Neumann, Franz-Josef
description Objectives: To assess the longitudinal compression behavior of platinum‐chromium everolimus‐eluting stents, evaluate frequency of inadvertent longitudinal compression during percutaneous intervention, and define patient‐ and lesion‐related predictors of this complication. Background: Platinum‐chromium stents of Element family have unique design features to improve flexibility that may, however, impair longitudinal stability. Incidence of longitudinal stent compression during implantation and predictors for this complication are not well understood. Methods: Five contemporary stent platforms were longitudinally compressed in a bench test experiment, and spring constant, yield force, and ultimate strength were calculated from force‐strain curves. We also evaluated all coronary cases treated with an Element stent from January 1, 2010, to October 31, 2011, for documented longitudinal compression. We compared baseline characteristics and periprocedural data between patients with and without longitudinal stent compression and assessed predictors for this event by multiple logistic regression models. Results: Yield force and ultimate strength were significantly lower for the Element compared with all other tested stents. In 20 patients (1.4%) and 20 lesions (0.7%) from 1,392 cases with 2,839 atherosclerotic lesions longitudinal stent compression was reported. Ostial segments, number of stents, and the presence of a bifurcation were significant predictors (adjusted odds ratios [95% confidence intervals]: 8.33 [3.30–21.28], 1.57 [1.01–2.45], 3.57 [1.36–9.35], respectively). Conclusion: The Element stent exhibits the lowest overall longitudinal strength compared with four contemporary platforms. Longitudinal compression of the Element stent is a rare complication and occurs more frequently in ostial or bifurcation lesions and with multiple stents. © 2012 Wiley Periodicals, Inc.
doi_str_mv 10.1002/ccd.24472
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Background: Platinum‐chromium stents of Element family have unique design features to improve flexibility that may, however, impair longitudinal stability. Incidence of longitudinal stent compression during implantation and predictors for this complication are not well understood. Methods: Five contemporary stent platforms were longitudinally compressed in a bench test experiment, and spring constant, yield force, and ultimate strength were calculated from force‐strain curves. We also evaluated all coronary cases treated with an Element stent from January 1, 2010, to October 31, 2011, for documented longitudinal compression. We compared baseline characteristics and periprocedural data between patients with and without longitudinal stent compression and assessed predictors for this event by multiple logistic regression models. Results: Yield force and ultimate strength were significantly lower for the Element compared with all other tested stents. In 20 patients (1.4%) and 20 lesions (0.7%) from 1,392 cases with 2,839 atherosclerotic lesions longitudinal stent compression was reported. Ostial segments, number of stents, and the presence of a bifurcation were significant predictors (adjusted odds ratios [95% confidence intervals]: 8.33 [3.30–21.28], 1.57 [1.01–2.45], 3.57 [1.36–9.35], respectively). Conclusion: The Element stent exhibits the lowest overall longitudinal strength compared with four contemporary platforms. 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Cardiovasc. Intervent</addtitle><description>Objectives: To assess the longitudinal compression behavior of platinum‐chromium everolimus‐eluting stents, evaluate frequency of inadvertent longitudinal compression during percutaneous intervention, and define patient‐ and lesion‐related predictors of this complication. Background: Platinum‐chromium stents of Element family have unique design features to improve flexibility that may, however, impair longitudinal stability. Incidence of longitudinal stent compression during implantation and predictors for this complication are not well understood. Methods: Five contemporary stent platforms were longitudinally compressed in a bench test experiment, and spring constant, yield force, and ultimate strength were calculated from force‐strain curves. We also evaluated all coronary cases treated with an Element stent from January 1, 2010, to October 31, 2011, for documented longitudinal compression. We compared baseline characteristics and periprocedural data between patients with and without longitudinal stent compression and assessed predictors for this event by multiple logistic regression models. Results: Yield force and ultimate strength were significantly lower for the Element compared with all other tested stents. In 20 patients (1.4%) and 20 lesions (0.7%) from 1,392 cases with 2,839 atherosclerotic lesions longitudinal stent compression was reported. Ostial segments, number of stents, and the presence of a bifurcation were significant predictors (adjusted odds ratios [95% confidence intervals]: 8.33 [3.30–21.28], 1.57 [1.01–2.45], 3.57 [1.36–9.35], respectively). Conclusion: The Element stent exhibits the lowest overall longitudinal strength compared with four contemporary platforms. 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dosage</subject><subject>Sirolimus - analogs &amp; derivatives</subject><subject>stent structure</subject><subject>Stress, Mechanical</subject><subject>Tomography, Optical Coherence</subject><subject>Treatment Outcome</subject><issn>1522-1946</issn><issn>1522-726X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhiNERUvhwAsgS1xAalrbiWOnN7RAqbQqHArtzXKcya5LbAc7Bvp2PBre7rYHpJ5sa77_n_H8RfGK4GOCMT3Ruj-mdc3pk-KAMEpLTpvrp7s7aetmv3ge4w3GuG1o-6zYp5QJwrE4KP4uvVuZOfXGqRFpb6cAMRrvkB_QvAY0jWo2LtlSr4O3JlkEvyD40dgUSxhTLq5QnMHNqE9h89A-eKfCLTI2i92c9d6doq8BehMnHzeMBb1Wzujccwp-gjAbiEfIOG16cBqOkHJ9LmWJnn2IuYIUGlVY5Ymy4aad9msf5hfF3qDGCC9352Hx7dPHy8Xncvnl7HzxflnqqiW07EQFDOqW84Yx1XSkFkozUWtBBt1wrHjf1x0ZlKC4U7ylqu20wIKLQVHMoDos3m5987w_E8RZWhM1jPmH4FOUpCJtU1W14Bl98x9641PI-72jhOCMEZypd1tKBx9jgEFOwdi8N0mw3MQqc6zyLtbMvt45ps5C_0De55iBky3w24xw-7iTXCw-3FuWW4XJ4f15UKjwQza84kxeXZzJ7-ySX181RPLqHws6wGw</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Leibundgut, Gregor</creator><creator>Gick, Michael</creator><creator>Toma, Aurel</creator><creator>Valina, Christian</creator><creator>Löffelhardt, Nikolaus</creator><creator>Joachim Büttner, Heinz</creator><creator>Neumann, Franz-Josef</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Longitudinal compression of the platinum-chromium everolimus-eluting stent during coronary implantation: Predisposing mechanical properties, incidence, and predictors in a large patient cohort</title><author>Leibundgut, Gregor ; 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dosage</topic><topic>Sirolimus - analogs &amp; derivatives</topic><topic>stent structure</topic><topic>Stress, Mechanical</topic><topic>Tomography, Optical Coherence</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leibundgut, Gregor</creatorcontrib><creatorcontrib>Gick, Michael</creatorcontrib><creatorcontrib>Toma, Aurel</creatorcontrib><creatorcontrib>Valina, Christian</creatorcontrib><creatorcontrib>Löffelhardt, Nikolaus</creatorcontrib><creatorcontrib>Joachim Büttner, Heinz</creatorcontrib><creatorcontrib>Neumann, Franz-Josef</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leibundgut, Gregor</au><au>Gick, Michael</au><au>Toma, Aurel</au><au>Valina, Christian</au><au>Löffelhardt, Nikolaus</au><au>Joachim Büttner, Heinz</au><au>Neumann, Franz-Josef</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal compression of the platinum-chromium everolimus-eluting stent during coronary implantation: Predisposing mechanical properties, incidence, and predictors in a large patient cohort</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Cathet. Cardiovasc. Intervent</addtitle><date>2013-04</date><risdate>2013</risdate><volume>81</volume><issue>5</issue><spage>E206</spage><epage>E214</epage><pages>E206-E214</pages><issn>1522-1946</issn><eissn>1522-726X</eissn><coden>CARIF2</coden><abstract>Objectives: To assess the longitudinal compression behavior of platinum‐chromium everolimus‐eluting stents, evaluate frequency of inadvertent longitudinal compression during percutaneous intervention, and define patient‐ and lesion‐related predictors of this complication. Background: Platinum‐chromium stents of Element family have unique design features to improve flexibility that may, however, impair longitudinal stability. Incidence of longitudinal stent compression during implantation and predictors for this complication are not well understood. Methods: Five contemporary stent platforms were longitudinally compressed in a bench test experiment, and spring constant, yield force, and ultimate strength were calculated from force‐strain curves. We also evaluated all coronary cases treated with an Element stent from January 1, 2010, to October 31, 2011, for documented longitudinal compression. We compared baseline characteristics and periprocedural data between patients with and without longitudinal stent compression and assessed predictors for this event by multiple logistic regression models. Results: Yield force and ultimate strength were significantly lower for the Element compared with all other tested stents. In 20 patients (1.4%) and 20 lesions (0.7%) from 1,392 cases with 2,839 atherosclerotic lesions longitudinal stent compression was reported. Ostial segments, number of stents, and the presence of a bifurcation were significant predictors (adjusted odds ratios [95% confidence intervals]: 8.33 [3.30–21.28], 1.57 [1.01–2.45], 3.57 [1.36–9.35], respectively). Conclusion: The Element stent exhibits the lowest overall longitudinal strength compared with four contemporary platforms. Longitudinal compression of the Element stent is a rare complication and occurs more frequently in ostial or bifurcation lesions and with multiple stents. © 2012 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>22581708</pmid><doi>10.1002/ccd.24472</doi><tpages>9</tpages></addata></record>
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subjects Aged
Cardiovascular Agents - administration & dosage
Chi-Square Distribution
Chromium
complications adult cath/intervention
Coronary Angiography
coronary artery disease
Coronary Artery Disease - diagnosis
Coronary Artery Disease - therapy
Drug-Eluting Stents
Equipment Failure Analysis
Everolimus
Female
Humans
Logistic Models
Male
Materials Testing
Middle Aged
Multivariate Analysis
Odds Ratio
percutaneous coronary intervention
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - instrumentation
Platinum
Prosthesis Design
Prosthesis Failure
Retrospective Studies
Risk Assessment
Risk Factors
Sirolimus - administration & dosage
Sirolimus - analogs & derivatives
stent structure
Stress, Mechanical
Tomography, Optical Coherence
Treatment Outcome
title Longitudinal compression of the platinum-chromium everolimus-eluting stent during coronary implantation: Predisposing mechanical properties, incidence, and predictors in a large patient cohort
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