Hyaluronic acid receptor-targetable imidazolized nanovectors for induction of gastric cancer cell death by RNA interference

Abstract We have developed a nanovector consisting of hyaluronic acid (HA) and poly- l -lysine- graft -imidazole (PLI)-based polyplexes containing Bcl-xL-specific shRNA-encoding plasmid DNA (HA/PLI/pDNA) for CD44 targeted gastric cancer therapy. The prepared ternary polyplexes have a negative surfac...

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Veröffentlicht in:	Biomaterials 2013-06, Vol.34 (17), p.4327-4338
Hauptverfasser:	Kim, Eunjung, Yang, Jaemoon, Kim, Hyun-Ouk, An, Yonghee, Lim, Eun-Kyung, Lee, Gyudo, Kwon, Taeyun, Cheong, Jae-Ho, Suh, Jin-Suck, Huh, Yong-Min, Haam, Seungjoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science bcl-X Protein - metabolism Buffering Cell Death - drug effects Cell Line, Tumor Cell Proliferation Dentistry DNA - metabolism Electrophoretic Mobility Shift Assay Gene delivery Genetic Vectors - metabolism Humans Hyaluronan Receptors - metabolism Hyaluronic acid Hydrogen-Ion Concentration Imidazole Imidazoles - chemistry Intracellular Space - metabolism Magnetic Resonance Spectroscopy Nanoparticles - chemistry Particle Size Plasmids - metabolism Polylysine - chemistry RNA Interference RNA, Small Interfering - metabolism Static Electricity Stomach Neoplasms - pathology Transfection
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