Prognostic significance of β-catenin expression in patients with non-small cell lung cancer: A meta-analysis
β-Catenin has been reported to play a crucial role in the invasion and metastasis of lung cancer. However, the value of β-catenin as a prognostic factor for non-small cell lung cancer (NSCLC) remains controversial. The present study systematically reviewed the evidence of predicting significance of...
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| Veröffentlicht in: | BioScience Trends 2013/02/28, Vol.7(1), pp.42-49 |
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| creator | Mei, Xiaodong Su, Hong Song, Jian Dong, Liang |
| description | β-Catenin has been reported to play a crucial role in the invasion and metastasis of lung cancer. However, the value of β-catenin as a prognostic factor for non-small cell lung cancer (NSCLC) remains controversial. The present study systematically reviewed the evidence of predicting significance of β-catenin expression in NSCLC patients with meta-analysis. Twelve literatures were included by searching PubMed, Cochrane library, and EMBASE databases. Separate hazard ratio estimates and a 95% confidence interval (CI) for the prognostic value of β-catenin in NSCLC were extracted and merged from the included literatures. The summary hazard ratios were 1.91 (95% CI 1.60-2.28), indicating a worse overall survival for NSCLC patients with reduced β-catenin expression. There Publication bias was not statistically significant. Sensitivity analysis showed that omission of any single study had little effect on the combined risk estimates. This meta-study revealed that decreased β-catenin expression denoted a poor prognosis in NSCLC patients. |
| doi_str_mv | 10.5582/bst.2013.v7.1.42 |
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However, the value of β-catenin as a prognostic factor for non-small cell lung cancer (NSCLC) remains controversial. The present study systematically reviewed the evidence of predicting significance of β-catenin expression in NSCLC patients with meta-analysis. Twelve literatures were included by searching PubMed, Cochrane library, and EMBASE databases. Separate hazard ratio estimates and a 95% confidence interval (CI) for the prognostic value of β-catenin in NSCLC were extracted and merged from the included literatures. The summary hazard ratios were 1.91 (95% CI 1.60-2.28), indicating a worse overall survival for NSCLC patients with reduced β-catenin expression. There Publication bias was not statistically significant. Sensitivity analysis showed that omission of any single study had little effect on the combined risk estimates. 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This meta-study revealed that decreased β-catenin expression denoted a poor prognosis in NSCLC patients.</description><subject>beta Catenin - metabolism</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - metabolism</subject><subject>Humans</subject><subject>non-small cell lung cancer</subject><subject>overall survival</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>β-Catenin</subject><issn>1881-7815</issn><issn>1881-7823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM9O3DAQh62qVUGUe0-Vj1wS_CdeO9wQlIKE1B7as2U7k8UocRaPl5bX6oPwTE1YWKk-jGfk33yyPkI-c1YrZcSpx1ILxmX9qGteN-IdOeTG8EobId_ve64OyDHiPZuPWnGjVx_JgZBKNKYVh2T8kad1mrDEQDGuU-xjcCkAnXr6_LcKrkCKicKfTQbEOCU6TxtXIqSC9HcsdzRNqcLRDQMNMJdhm9b0hZHP6DkdobjKJTc8YcRP5EPvBoTj1_uI_Lr6-vPiurr9_u3m4vy2Ck0rStVJbUAZ03HfMib7FRedkSsNppG9l957pY10nDOvm8ChC75TbcuCV6ER0sgjcrLjbvL0sAUsdoy4_M4lmLZoueTt7IIJMUfZLhryhJiht5scR5efLGd28Wxnz3bxbB-15bZZVr680rd-hG6_8GZ1DlzuAvdY3Br2AZdnzQO8EBeW_o-7fw53LltI8h-aFJP3</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Mei, Xiaodong</creator><creator>Su, Hong</creator><creator>Song, Jian</creator><creator>Dong, Liang</creator><general>International Research and Cooperation Association for Bio & Socio-Sciences Advancement</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Prognostic significance of β-catenin expression in patients with non-small cell lung cancer: A meta-analysis</title><author>Mei, Xiaodong ; Su, Hong ; Song, Jian ; Dong, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c492t-d378e588d1b9003f612d8367e843fb3bbb5783a110b74c1edcbd5990cb5c42383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>beta Catenin - metabolism</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnosis</topic><topic>Carcinoma, Non-Small-Cell Lung - metabolism</topic><topic>Humans</topic><topic>non-small cell lung cancer</topic><topic>overall survival</topic><topic>Prognosis</topic><topic>Survival Analysis</topic><topic>β-Catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mei, Xiaodong</creatorcontrib><creatorcontrib>Su, Hong</creatorcontrib><creatorcontrib>Song, Jian</creatorcontrib><creatorcontrib>Dong, Liang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BioScience Trends</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mei, Xiaodong</au><au>Su, Hong</au><au>Song, Jian</au><au>Dong, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of β-catenin expression in patients with non-small cell lung cancer: A meta-analysis</atitle><jtitle>BioScience Trends</jtitle><addtitle>BST</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>7</volume><issue>1</issue><spage>42</spage><epage>49</epage><pages>42-49</pages><issn>1881-7815</issn><eissn>1881-7823</eissn><abstract>β-Catenin has been reported to play a crucial role in the invasion and metastasis of lung cancer. 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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | beta Catenin - metabolism Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - metabolism Humans non-small cell lung cancer overall survival Prognosis Survival Analysis β-Catenin |
| title | Prognostic significance of β-catenin expression in patients with non-small cell lung cancer: A meta-analysis |
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