NMR Solution Structure of a DNA−Actinomycin D Complex Containing a Non-Hydrogen-Bonding Pair in the Binding Site

The solution structures of two different DNA duplexes (one containing a G-T mismatched base pair and the other a non-hydrogen-bonding G-F pair, where F is difluorotoluene) in complex with the peptide antibiotic actinomycin D (ActD) are presented. Using 1H, 19F NMR, and molecular dynamics simulations...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-12, Vol.132 (49), p.17588-17598
Hauptverfasser:	Cravens, Shannen L, Navapanich, Alyssa C, Geierstanger, Bernhard H, Tahmassebi, Deborah C, Dwyer, Tammy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Base Pairing Base Sequence Binding Sites Dactinomycin - chemistry Dactinomycin - metabolism DNA - chemistry DNA - metabolism Hydrogen Bonding Intercalating Agents - chemistry Intercalating Agents - metabolism Molecular Dynamics Simulation Nuclear Magnetic Resonance, Biomolecular Nucleic Acid Conformation
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