Interactions of selected indole derivatives with phospholipase A2: in silico and in vitro analysis

Phospholipase A2 (PLA 2 ) is one of the key enzymes involved in the formation of inflammatory mediators. Inhibition of PLA 2 is considered to be one of the efficient methods to control inflammation. In silico docking studies of 160 selected indole derivatives performed against porcine pancreatic PLA...

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Veröffentlicht in:	Journal of molecular modeling 2013-04, Vol.19 (4), p.1811-1817
Hauptverfasser:	Dileep, Kalarickal Vijayan, Remya, Chandran, Tintu, Ignatius, Haridas, Madathilkovilakathu, Sadasivan, Chittalakkottu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Binding Sites Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Computer Appl. in Life Sciences Computer Applications in Chemistry Enzyme Inhibitors - chemistry Humans Indoleacetic Acids - chemistry Indoles - chemistry Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Kinetics Molecular Docking Simulation Molecular Medicine Original Paper Pancreas - chemistry Pancreas - enzymology Phospholipase A2 Inhibitors Phospholipases A2 - chemistry Protein Binding Swine Theoretical and Computational Chemistry Thermodynamics
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