Effect of short-term reduced physical activity on cardiovascular risk factors in active lean and overweight middle-aged men

Abstract Objectives An experimental reduction in physical activity is a useful tool for exploring the health benefits of physical activity. This study investigated whether similarly-active overweight men show a more pronounced response to reduced physical activity than their lean counterparts becaus...

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Veröffentlicht in:Metabolism, clinical and experimental clinical and experimental, 2013-03, Vol.62 (3), p.361-368
Hauptverfasser: Dixon, Natalie C, Hurst, Tina L, Talbot, Duncan C.S, Tyrrell, Rex M, Thompson, Dylan
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container_issue 3
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container_title Metabolism, clinical and experimental
container_volume 62
creator Dixon, Natalie C
Hurst, Tina L
Talbot, Duncan C.S
Tyrrell, Rex M
Thompson, Dylan
description Abstract Objectives An experimental reduction in physical activity is a useful tool for exploring the health benefits of physical activity. This study investigated whether similarly-active overweight men show a more pronounced response to reduced physical activity than their lean counterparts because of their atherogenic phenotype (i.e., greater abdominal adiposity). Methods From 115 active men aged 45–64 years, we recruited nine active lean (waist circumference < 84 cm) and nine active central overweight men (waist circumference > 94 cm). Fasting blood samples and responses to an oral glucose tolerance test (OGTT) were measured at baseline and following one week of reduced physical activity to simulate sedentary levels (removal of structured exercise and reduced habitual physical activity). Results Glucose and insulin areas under the curve (AUC), CRP, ALT, TAG were all higher in the overweight group and remained so throughout ( P < 0.05). Insulin and glucose AUC responses to an OGTT, as well as fasting triglyceride (TAG) concentrations, increased in both groups as a result of the intervention ( P < 0.05). There was no change in interleukin-6, C-reactive protein (CRP), Tumour Necrosis Factor-α, soluble intracellular adhesion molecule 1, or alanine transaminase (ALT). Conclusion One-week of reduced activity similarly-impaired glucose control and increased fasting TAG in both lean and overweight men. Importantly, in spite of very similar (high) levels of habitual physical activity, central overweight men displayed a poorer profile for various inflammatory and metabolic outcomes (CRP, ALT, TAG, glucose AUC and insulin AUC).
doi_str_mv 10.1016/j.metabol.2012.08.006
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This study investigated whether similarly-active overweight men show a more pronounced response to reduced physical activity than their lean counterparts because of their atherogenic phenotype (i.e., greater abdominal adiposity). Methods From 115 active men aged 45–64 years, we recruited nine active lean (waist circumference &lt; 84 cm) and nine active central overweight men (waist circumference &gt; 94 cm). Fasting blood samples and responses to an oral glucose tolerance test (OGTT) were measured at baseline and following one week of reduced physical activity to simulate sedentary levels (removal of structured exercise and reduced habitual physical activity). Results Glucose and insulin areas under the curve (AUC), CRP, ALT, TAG were all higher in the overweight group and remained so throughout ( P &lt; 0.05). Insulin and glucose AUC responses to an OGTT, as well as fasting triglyceride (TAG) concentrations, increased in both groups as a result of the intervention ( P &lt; 0.05). There was no change in interleukin-6, C-reactive protein (CRP), Tumour Necrosis Factor-α, soluble intracellular adhesion molecule 1, or alanine transaminase (ALT). Conclusion One-week of reduced activity similarly-impaired glucose control and increased fasting TAG in both lean and overweight men. Importantly, in spite of very similar (high) levels of habitual physical activity, central overweight men displayed a poorer profile for various inflammatory and metabolic outcomes (CRP, ALT, TAG, glucose AUC and insulin AUC).</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/j.metabol.2012.08.006</identifier><identifier>PMID: 22995864</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abdominal adiposity ; Alanine Transaminase - blood ; Area Under Curve ; Biological and medical sciences ; Blood glucose ; Blood Glucose - metabolism ; C-Reactive Protein - metabolism ; Cardiology. Vascular system ; Coronary heart disease ; Endocrinology &amp; Metabolism ; Exercise ; Exercise - physiology ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Glucose Tolerance Test ; Heart ; Humans ; Inflammation ; Insulin - blood ; Intercellular Adhesion Molecule-1 - blood ; Interleukin-6 - blood ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Obesity ; Overweight ; Overweight - blood ; Overweight - metabolism ; Overweight - physiopathology ; Physical activity ; Triglycerides - blood ; Tumor Necrosis Factor-alpha - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Waist Circumference - physiology</subject><ispartof>Metabolism, clinical and experimental, 2013-03, Vol.62 (3), p.361-368</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Inc. 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This study investigated whether similarly-active overweight men show a more pronounced response to reduced physical activity than their lean counterparts because of their atherogenic phenotype (i.e., greater abdominal adiposity). Methods From 115 active men aged 45–64 years, we recruited nine active lean (waist circumference &lt; 84 cm) and nine active central overweight men (waist circumference &gt; 94 cm). Fasting blood samples and responses to an oral glucose tolerance test (OGTT) were measured at baseline and following one week of reduced physical activity to simulate sedentary levels (removal of structured exercise and reduced habitual physical activity). Results Glucose and insulin areas under the curve (AUC), CRP, ALT, TAG were all higher in the overweight group and remained so throughout ( P &lt; 0.05). Insulin and glucose AUC responses to an OGTT, as well as fasting triglyceride (TAG) concentrations, increased in both groups as a result of the intervention ( P &lt; 0.05). There was no change in interleukin-6, C-reactive protein (CRP), Tumour Necrosis Factor-α, soluble intracellular adhesion molecule 1, or alanine transaminase (ALT). Conclusion One-week of reduced activity similarly-impaired glucose control and increased fasting TAG in both lean and overweight men. Importantly, in spite of very similar (high) levels of habitual physical activity, central overweight men displayed a poorer profile for various inflammatory and metabolic outcomes (CRP, ALT, TAG, glucose AUC and insulin AUC).</description><subject>Abdominal adiposity</subject><subject>Alanine Transaminase - blood</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Blood glucose</subject><subject>Blood Glucose - metabolism</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiology. Vascular system</subject><subject>Coronary heart disease</subject><subject>Endocrinology &amp; Metabolism</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose Tolerance Test</subject><subject>Heart</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Insulin - blood</subject><subject>Intercellular Adhesion Molecule-1 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Overweight - blood</subject><subject>Overweight - metabolism</subject><subject>Overweight - physiopathology</subject><subject>Physical activity</subject><subject>Triglycerides - blood</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Waist Circumference - physiology</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEokvhJ4B8QeKSMI4dx7mAqqp8SJU4AGfLscddb5N4sZNFK_48jnYBiQuc7MMzr8fzTFE8p1BRoOL1rhpx1n0YqhpoXYGsAMSDYkMbVpdSADwsNgC1KIF3zUXxJKUdALStFI-Li7ruukYKvil-3DiHZibBkbQNcS5njCOJaBeDluy3x-SNHog2sz_4-UjCRIyO1oeDTmYZdCTRp3viMhBiIn46oUgG1Pk-WRIOGL-jv9vOZPTWDljquxw94vS0eOT0kPDZ-bwsvr67-XL9obz99P7j9dVtaRoGc9mhAI5aNMZy6aRlqHXvWkYbyWnbOWc7ztHk7_cCTW-01LxzrMeeC5sxdlm8OuXuY_i2YJrV6JPBYdAThiUpyqgUnWTwH2gtOy5rKpuMNifUxJBSRKf20Y86HhUFtSpSO3VWpFZFCqTKPea6F-cnln5E-7vql5MMvDwDecR6cFFPxqc_XEs5FZRl7u2Jwzy7g8eokvE4ZW8-ZqXKBv_PVt78lWAGP63C7_GIaReWOGUxiqqUa9TndZ_WdaI1AMu57CcZLsi1</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Dixon, Natalie C</creator><creator>Hurst, Tina L</creator><creator>Talbot, Duncan C.S</creator><creator>Tyrrell, Rex M</creator><creator>Thompson, Dylan</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TS</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20130301</creationdate><title>Effect of short-term reduced physical activity on cardiovascular risk factors in active lean and overweight middle-aged men</title><author>Dixon, Natalie C ; Hurst, Tina L ; Talbot, Duncan C.S ; Tyrrell, Rex M ; Thompson, Dylan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-9e604ea65cd48f8d3eaabf731584179ffd944ec006b6ecbca8a49f3beb46d7313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abdominal adiposity</topic><topic>Alanine Transaminase - blood</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Blood glucose</topic><topic>Blood Glucose - metabolism</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiology. Vascular system</topic><topic>Coronary heart disease</topic><topic>Endocrinology &amp; Metabolism</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose Tolerance Test</topic><topic>Heart</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Insulin - blood</topic><topic>Intercellular Adhesion Molecule-1 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Overweight</topic><topic>Overweight - blood</topic><topic>Overweight - metabolism</topic><topic>Overweight - physiopathology</topic><topic>Physical activity</topic><topic>Triglycerides - blood</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Waist Circumference - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dixon, Natalie C</creatorcontrib><creatorcontrib>Hurst, Tina L</creatorcontrib><creatorcontrib>Talbot, Duncan C.S</creatorcontrib><creatorcontrib>Tyrrell, Rex M</creatorcontrib><creatorcontrib>Thompson, Dylan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Physical Education Index</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dixon, Natalie C</au><au>Hurst, Tina L</au><au>Talbot, Duncan C.S</au><au>Tyrrell, Rex M</au><au>Thompson, Dylan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of short-term reduced physical activity on cardiovascular risk factors in active lean and overweight middle-aged men</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>62</volume><issue>3</issue><spage>361</spage><epage>368</epage><pages>361-368</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Abstract Objectives An experimental reduction in physical activity is a useful tool for exploring the health benefits of physical activity. This study investigated whether similarly-active overweight men show a more pronounced response to reduced physical activity than their lean counterparts because of their atherogenic phenotype (i.e., greater abdominal adiposity). Methods From 115 active men aged 45–64 years, we recruited nine active lean (waist circumference &lt; 84 cm) and nine active central overweight men (waist circumference &gt; 94 cm). Fasting blood samples and responses to an oral glucose tolerance test (OGTT) were measured at baseline and following one week of reduced physical activity to simulate sedentary levels (removal of structured exercise and reduced habitual physical activity). Results Glucose and insulin areas under the curve (AUC), CRP, ALT, TAG were all higher in the overweight group and remained so throughout ( P &lt; 0.05). Insulin and glucose AUC responses to an OGTT, as well as fasting triglyceride (TAG) concentrations, increased in both groups as a result of the intervention ( P &lt; 0.05). There was no change in interleukin-6, C-reactive protein (CRP), Tumour Necrosis Factor-α, soluble intracellular adhesion molecule 1, or alanine transaminase (ALT). Conclusion One-week of reduced activity similarly-impaired glucose control and increased fasting TAG in both lean and overweight men. Importantly, in spite of very similar (high) levels of habitual physical activity, central overweight men displayed a poorer profile for various inflammatory and metabolic outcomes (CRP, ALT, TAG, glucose AUC and insulin AUC).</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22995864</pmid><doi>10.1016/j.metabol.2012.08.006</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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subjects Abdominal adiposity
Alanine Transaminase - blood
Area Under Curve
Biological and medical sciences
Blood glucose
Blood Glucose - metabolism
C-Reactive Protein - metabolism
Cardiology. Vascular system
Coronary heart disease
Endocrinology & Metabolism
Exercise
Exercise - physiology
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
Glucose Tolerance Test
Heart
Humans
Inflammation
Insulin - blood
Intercellular Adhesion Molecule-1 - blood
Interleukin-6 - blood
Male
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Overweight
Overweight - blood
Overweight - metabolism
Overweight - physiopathology
Physical activity
Triglycerides - blood
Tumor Necrosis Factor-alpha - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Waist Circumference - physiology
title Effect of short-term reduced physical activity on cardiovascular risk factors in active lean and overweight middle-aged men
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