The emulsified perfluorocarbon Oxycyte improves spinal cord injury in a swine model of decompression sickness
Study design: A prospective, animal model for pharmacological intervention of decompression sickness (DCS), including spinal cord (SC) injury. Background: Signs and symptoms of DCS can include joint pain, skin discoloration, cardiopulmonary congestion and SC injury; severity ranges from trivial to f...
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| Veröffentlicht in: | Spinal cord 2013-03, Vol.51 (3), p.188-192 |
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| creator | Mahon, R T Auker, C R Bradley, S G Mendelson, A Hall, A A |
| description | Study design:
A prospective, animal model for pharmacological intervention of decompression sickness (DCS), including spinal cord (SC) injury.
Background:
Signs and symptoms of DCS can include joint pain, skin discoloration, cardiopulmonary congestion and SC injury; severity ranges from trivial to fatal. Non-recompressive therapy for DCS may improve time-to-treatment and therefore impact mortality and morbidity.
Objectives:
Oxycyte at 5 cc kg
−1
provides both SC protection and statistically significant survival benefit in a swine model of DCS. The purpose of this study was to test whether a reduced dose of Oxycyte (3 cc kg
−1
) would provide similar benefit.
Setting:
Silver Spring, MD, USA
Methods:
Male Yorkshire swine (
N
=50) underwent a non-linear compression profile to 200 fsw (feet of sea water), which was identical to previous work using the 5 cc kg
−1
dose of Oxycyte. After 31 min of bottom time, decompression was initiated at 30 fsw per minute until surface pressure was reached. Following decompression and the onset of DCS, intravenous Oxycyte or saline was administered with concurrent 100% O
2
for 1 h. The primary end point was DCS-induced mortality, with Tarlov score and SC histopathology as secondary end points.
Results:
Oxycyte administration of 3 cc kg
−1
following surfacing produced no significant detectable survival benefit. Animals that received Oxycyte, however, had reduced SC lesion area.
Conclusion:
Further studies to determine the lowest fully efficacious dose of Oxycyte for the adjunct treatment of DCS are warranted. |
| doi_str_mv | 10.1038/sc.2012.135 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1318697879</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1318697879</sourcerecordid><originalsourceid>FETCH-LOGICAL-c424t-87b0fa598d2d10981eb3ca1b43eb534444d1d9e9be3fb62f7c4a2370fcd4928b3</originalsourceid><addsrcrecordid>eNqNkU1vFDEMhiMEomXhxB1F4oJUZsnXzCRHVFFAqtRLex7lw4EsM5Ml3gH235PtFoSqHvDFlvz4teWXkJecrTmT-h36tWBcrLlsH5FTrvquaTuhHtdadqJR0sgT8gxxwxgz3Oin5ERI3rUt607JdP0VKEzLiCkmCHQLJY5LLtnb4vJMr37t_X4HNE3bkn8AUtym2Y7U5xJomjdL2ddELcWfaQY65QAjzZEG8LmOAGKqKpj8t7nWz8mTaEeEF3d5RW4uPlyff2ourz5-Pn9_2Xgl1K7RvWPRtkYHETgzmoOT3nKnJLhWqhqBBwPGgYyuE7H3ygrZs-iDMkI7uSJvjrr16O8L4G6YEnoYRztDXnDgkuvO9Lo3_4MqKYTu2oq-vodu8lLqN24p2UrWV3ZFzo6ULxmxQBy2JU227AfOhoNhA_rhYNhwGFmRV3eai5sg_GX_OFSBt0cAa2v-AuWfpQ_o_QYqWKAA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1313530714</pqid></control><display><type>article</type><title>The emulsified perfluorocarbon Oxycyte improves spinal cord injury in a swine model of decompression sickness</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Mahon, R T ; Auker, C R ; Bradley, S G ; Mendelson, A ; Hall, A A</creator><creatorcontrib>Mahon, R T ; Auker, C R ; Bradley, S G ; Mendelson, A ; Hall, A A</creatorcontrib><description>Study design:
A prospective, animal model for pharmacological intervention of decompression sickness (DCS), including spinal cord (SC) injury.
Background:
Signs and symptoms of DCS can include joint pain, skin discoloration, cardiopulmonary congestion and SC injury; severity ranges from trivial to fatal. Non-recompressive therapy for DCS may improve time-to-treatment and therefore impact mortality and morbidity.
Objectives:
Oxycyte at 5 cc kg
−1
provides both SC protection and statistically significant survival benefit in a swine model of DCS. The purpose of this study was to test whether a reduced dose of Oxycyte (3 cc kg
−1
) would provide similar benefit.
Setting:
Silver Spring, MD, USA
Methods:
Male Yorkshire swine (
N
=50) underwent a non-linear compression profile to 200 fsw (feet of sea water), which was identical to previous work using the 5 cc kg
−1
dose of Oxycyte. After 31 min of bottom time, decompression was initiated at 30 fsw per minute until surface pressure was reached. Following decompression and the onset of DCS, intravenous Oxycyte or saline was administered with concurrent 100% O
2
for 1 h. The primary end point was DCS-induced mortality, with Tarlov score and SC histopathology as secondary end points.
Results:
Oxycyte administration of 3 cc kg
−1
following surfacing produced no significant detectable survival benefit. Animals that received Oxycyte, however, had reduced SC lesion area.
Conclusion:
Further studies to determine the lowest fully efficacious dose of Oxycyte for the adjunct treatment of DCS are warranted.</description><identifier>ISSN: 1362-4393</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/sc.2012.135</identifier><identifier>PMID: 23165506</identifier><identifier>CODEN: SPCOFM</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/154/436 ; 631/378/1687/1825 ; 692/699/578 ; Anatomy ; Animal models ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cell survival ; Compression ; Decompression ; Decompression Sickness - drug therapy ; Decompression Sickness - mortality ; Decompression Sickness - pathology ; Dendritic cells ; Disease Models, Animal ; Emulsions ; Fluorocarbons - therapeutic use ; Human Physiology ; Intravenous administration ; Joints ; Male ; Marine environment ; Morbidity ; Mortality ; Neurochemistry ; Neuropsychology ; Neurosciences ; original-article ; Pain ; Pressure ; Prospective Studies ; Skin ; Spinal Cord Injuries - drug therapy ; Spinal Cord Injuries - mortality ; Spinal Cord Injuries - pathology ; Spinal cord injury ; Statistical analysis ; Swine</subject><ispartof>Spinal cord, 2013-03, Vol.51 (3), p.188-192</ispartof><rights>International Spinal Cord Society 2013</rights><rights>Copyright Nature Publishing Group Mar 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-87b0fa598d2d10981eb3ca1b43eb534444d1d9e9be3fb62f7c4a2370fcd4928b3</citedby><cites>FETCH-LOGICAL-c424t-87b0fa598d2d10981eb3ca1b43eb534444d1d9e9be3fb62f7c4a2370fcd4928b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sc.2012.135$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sc.2012.135$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23165506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahon, R T</creatorcontrib><creatorcontrib>Auker, C R</creatorcontrib><creatorcontrib>Bradley, S G</creatorcontrib><creatorcontrib>Mendelson, A</creatorcontrib><creatorcontrib>Hall, A A</creatorcontrib><title>The emulsified perfluorocarbon Oxycyte improves spinal cord injury in a swine model of decompression sickness</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><addtitle>Spinal Cord</addtitle><description>Study design:
A prospective, animal model for pharmacological intervention of decompression sickness (DCS), including spinal cord (SC) injury.
Background:
Signs and symptoms of DCS can include joint pain, skin discoloration, cardiopulmonary congestion and SC injury; severity ranges from trivial to fatal. Non-recompressive therapy for DCS may improve time-to-treatment and therefore impact mortality and morbidity.
Objectives:
Oxycyte at 5 cc kg
−1
provides both SC protection and statistically significant survival benefit in a swine model of DCS. The purpose of this study was to test whether a reduced dose of Oxycyte (3 cc kg
−1
) would provide similar benefit.
Setting:
Silver Spring, MD, USA
Methods:
Male Yorkshire swine (
N
=50) underwent a non-linear compression profile to 200 fsw (feet of sea water), which was identical to previous work using the 5 cc kg
−1
dose of Oxycyte. After 31 min of bottom time, decompression was initiated at 30 fsw per minute until surface pressure was reached. Following decompression and the onset of DCS, intravenous Oxycyte or saline was administered with concurrent 100% O
2
for 1 h. The primary end point was DCS-induced mortality, with Tarlov score and SC histopathology as secondary end points.
Results:
Oxycyte administration of 3 cc kg
−1
following surfacing produced no significant detectable survival benefit. Animals that received Oxycyte, however, had reduced SC lesion area.
Conclusion:
Further studies to determine the lowest fully efficacious dose of Oxycyte for the adjunct treatment of DCS are warranted.</description><subject>631/154/436</subject><subject>631/378/1687/1825</subject><subject>692/699/578</subject><subject>Anatomy</subject><subject>Animal models</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell survival</subject><subject>Compression</subject><subject>Decompression</subject><subject>Decompression Sickness - drug therapy</subject><subject>Decompression Sickness - mortality</subject><subject>Decompression Sickness - pathology</subject><subject>Dendritic cells</subject><subject>Disease Models, Animal</subject><subject>Emulsions</subject><subject>Fluorocarbons - therapeutic use</subject><subject>Human Physiology</subject><subject>Intravenous administration</subject><subject>Joints</subject><subject>Male</subject><subject>Marine environment</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Neurochemistry</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>original-article</subject><subject>Pain</subject><subject>Pressure</subject><subject>Prospective Studies</subject><subject>Skin</subject><subject>Spinal Cord Injuries - drug therapy</subject><subject>Spinal Cord Injuries - mortality</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Spinal cord injury</subject><subject>Statistical analysis</subject><subject>Swine</subject><issn>1362-4393</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1vFDEMhiMEomXhxB1F4oJUZsnXzCRHVFFAqtRLex7lw4EsM5Ml3gH235PtFoSqHvDFlvz4teWXkJecrTmT-h36tWBcrLlsH5FTrvquaTuhHtdadqJR0sgT8gxxwxgz3Oin5ERI3rUt607JdP0VKEzLiCkmCHQLJY5LLtnb4vJMr37t_X4HNE3bkn8AUtym2Y7U5xJomjdL2ddELcWfaQY65QAjzZEG8LmOAGKqKpj8t7nWz8mTaEeEF3d5RW4uPlyff2ourz5-Pn9_2Xgl1K7RvWPRtkYHETgzmoOT3nKnJLhWqhqBBwPGgYyuE7H3ygrZs-iDMkI7uSJvjrr16O8L4G6YEnoYRztDXnDgkuvO9Lo3_4MqKYTu2oq-vodu8lLqN24p2UrWV3ZFzo6ULxmxQBy2JU227AfOhoNhA_rhYNhwGFmRV3eai5sg_GX_OFSBt0cAa2v-AuWfpQ_o_QYqWKAA</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Mahon, R T</creator><creator>Auker, C R</creator><creator>Bradley, S G</creator><creator>Mendelson, A</creator><creator>Hall, A A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>The emulsified perfluorocarbon Oxycyte improves spinal cord injury in a swine model of decompression sickness</title><author>Mahon, R T ; Auker, C R ; Bradley, S G ; Mendelson, A ; Hall, A A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-87b0fa598d2d10981eb3ca1b43eb534444d1d9e9be3fb62f7c4a2370fcd4928b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/154/436</topic><topic>631/378/1687/1825</topic><topic>692/699/578</topic><topic>Anatomy</topic><topic>Animal models</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell survival</topic><topic>Compression</topic><topic>Decompression</topic><topic>Decompression Sickness - drug therapy</topic><topic>Decompression Sickness - mortality</topic><topic>Decompression Sickness - pathology</topic><topic>Dendritic cells</topic><topic>Disease Models, Animal</topic><topic>Emulsions</topic><topic>Fluorocarbons - therapeutic use</topic><topic>Human Physiology</topic><topic>Intravenous administration</topic><topic>Joints</topic><topic>Male</topic><topic>Marine environment</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Neurochemistry</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>original-article</topic><topic>Pain</topic><topic>Pressure</topic><topic>Prospective Studies</topic><topic>Skin</topic><topic>Spinal Cord Injuries - drug therapy</topic><topic>Spinal Cord Injuries - mortality</topic><topic>Spinal Cord Injuries - pathology</topic><topic>Spinal cord injury</topic><topic>Statistical analysis</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahon, R T</creatorcontrib><creatorcontrib>Auker, C R</creatorcontrib><creatorcontrib>Bradley, S G</creatorcontrib><creatorcontrib>Mendelson, A</creatorcontrib><creatorcontrib>Hall, A A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Spinal cord</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahon, R T</au><au>Auker, C R</au><au>Bradley, S G</au><au>Mendelson, A</au><au>Hall, A A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The emulsified perfluorocarbon Oxycyte improves spinal cord injury in a swine model of decompression sickness</atitle><jtitle>Spinal cord</jtitle><stitle>Spinal Cord</stitle><addtitle>Spinal Cord</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>51</volume><issue>3</issue><spage>188</spage><epage>192</epage><pages>188-192</pages><issn>1362-4393</issn><eissn>1476-5624</eissn><coden>SPCOFM</coden><abstract>Study design:
A prospective, animal model for pharmacological intervention of decompression sickness (DCS), including spinal cord (SC) injury.
Background:
Signs and symptoms of DCS can include joint pain, skin discoloration, cardiopulmonary congestion and SC injury; severity ranges from trivial to fatal. Non-recompressive therapy for DCS may improve time-to-treatment and therefore impact mortality and morbidity.
Objectives:
Oxycyte at 5 cc kg
−1
provides both SC protection and statistically significant survival benefit in a swine model of DCS. The purpose of this study was to test whether a reduced dose of Oxycyte (3 cc kg
−1
) would provide similar benefit.
Setting:
Silver Spring, MD, USA
Methods:
Male Yorkshire swine (
N
=50) underwent a non-linear compression profile to 200 fsw (feet of sea water), which was identical to previous work using the 5 cc kg
−1
dose of Oxycyte. After 31 min of bottom time, decompression was initiated at 30 fsw per minute until surface pressure was reached. Following decompression and the onset of DCS, intravenous Oxycyte or saline was administered with concurrent 100% O
2
for 1 h. The primary end point was DCS-induced mortality, with Tarlov score and SC histopathology as secondary end points.
Results:
Oxycyte administration of 3 cc kg
−1
following surfacing produced no significant detectable survival benefit. Animals that received Oxycyte, however, had reduced SC lesion area.
Conclusion:
Further studies to determine the lowest fully efficacious dose of Oxycyte for the adjunct treatment of DCS are warranted.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23165506</pmid><doi>10.1038/sc.2012.135</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1362-4393 |
| ispartof | Spinal cord, 2013-03, Vol.51 (3), p.188-192 |
| issn | 1362-4393 1476-5624 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1318697879 |
| source | MEDLINE; SpringerLink Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 631/154/436 631/378/1687/1825 692/699/578 Anatomy Animal models Animals Biomedical and Life Sciences Biomedicine Cell survival Compression Decompression Decompression Sickness - drug therapy Decompression Sickness - mortality Decompression Sickness - pathology Dendritic cells Disease Models, Animal Emulsions Fluorocarbons - therapeutic use Human Physiology Intravenous administration Joints Male Marine environment Morbidity Mortality Neurochemistry Neuropsychology Neurosciences original-article Pain Pressure Prospective Studies Skin Spinal Cord Injuries - drug therapy Spinal Cord Injuries - mortality Spinal Cord Injuries - pathology Spinal cord injury Statistical analysis Swine |
| title | The emulsified perfluorocarbon Oxycyte improves spinal cord injury in a swine model of decompression sickness |
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