MicroRNAs and lung development
MicroRNAs (miRNAs) constitute a large group of small (∼22 nucleotides), non‐coding RNA sequences that are highly conserved among animals, plants and microorganisms, suggesting that microRNAs represent a highly conserved and important regulatory mechanism. They have been demonstrated to play an impor...
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| Veröffentlicht in: | Pediatric pulmonology 2013-04, Vol.48 (4), p.317-323 |
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| container_title | Pediatric pulmonology |
| container_volume | 48 |
| creator | Khoshgoo, Naghmeh Kholdebarin, Ramin Iwasiow, Barbara Maria Keijzer, Richard |
| description | MicroRNAs (miRNAs) constitute a large group of small (∼22 nucleotides), non‐coding RNA sequences that are highly conserved among animals, plants and microorganisms, suggesting that microRNAs represent a highly conserved and important regulatory mechanism. They have been demonstrated to play an important role in gene regulation. Recently, miRNAs have become a major focus of interest for research in organ development. Research focusing on the potential role of microRNAs during lung development is slowly starting to emerge. A number of miRNAs have been demonstrated to play important roles during early and late lung development. Several studies have begun to profile miRNA expression at various stages of lung development and this article provides an overview of the various miRNAs that have been implicated in lung organogenesis. Pediatr Pulmonol. 2013; 48:317–323. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/ppul.22739 |
| format | Article |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Gene Expression Regulation, Developmental Humans let-7 Lung - embryology lung development microRNA MicroRNAs miR-17 ∼ 92 cluster miRNA Organogenesis - genetics |
| title | MicroRNAs and lung development |
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