Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome

Euchromatin histone methyltransferase 1 (EHMT1) is a highly conserved protein that catalyzes mono- and dimethylation of histone H3 lysine 9, thereby epigenetically regulating transcription. Kleefstra syndrome (KS), is caused by haploinsufficiency of the EHMT1 gene, and is an example of an emerging g...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human molecular genetics 2013-03, Vol.22 (5), p.852-866
Hauptverfasser:	Balemans, Monique C M, Kasri, Nael Nadif, Kopanitsa, Maksym V, Afinowi, Nurudeen O, Ramakers, Ger, Peters, Theo A, Beynon, Andy J, Janssen, Sanne M, van Summeren, Rik C J, Eeftens, Jorine M, Eikelenboom, Nathalie, Benevento, Marco, Tachibana, Makoto, Shinkai, Yoichi, Kleefstra, Tjitske, van Bokhoven, Hans, Van der Zee, Catharina E E M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromosome Deletion Chromosomes, Human, Pair 9 - genetics Craniofacial Abnormalities - genetics Disease Models, Animal Heart Defects, Congenital - genetics Hippocampus - metabolism Hippocampus - pathology Histone-Lysine N-Methyltransferase - genetics Histone-Lysine N-Methyltransferase - metabolism Humans Intellectual Disability - genetics Intellectual Disability - physiopathology Learning Mice Mice, Knockout Pyramidal Cells - pathology Synapses - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!