Comparative evaluation of a co-processed self-lubricating excipient LubriTose SD as a direct compression vehicle
LubriTose SD is a new co-processed excipient consisting of spray-dried monohydrate lactose and distilled glyceryl monostearate. In this study, the new self-lubricating excipient LubriTose SD was characterized from the aspects of powder technological properties and tableting properties. Micromeritic...
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| Veröffentlicht in: | Journal of drug delivery science and technology 2012-01, Vol.22 (6), p.562-567 |
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| container_title | Journal of drug delivery science and technology |
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| creator | Tian, J.-L. Tian, C. Ke, X. |
| description | LubriTose SD is a new co-processed excipient consisting of spray-dried monohydrate lactose and distilled glyceryl monostearate. In this study, the new self-lubricating excipient LubriTose SD was characterized from the aspects of powder technological properties and tableting properties. Micromeritic properties, including particle shape, size distribution, flowability, compressibility, and also the dilution potential were determined. Its applications in powder direct compression have been evaluated, including the effects on flowability, compressibility, the lubricating ability, hygroscopic drugs stability, content uniformity of the low-dose drugs and dissolution of poorly soluble drugs. LubriTose SD is 100 μm with very uniform size distribution and with spherical shape, shows the best flowability, has the same deformation mechanism with the spray-dried monohydrate lactose, has high dilution potential to the hydrophobic drug and has improved function of drug tableting. Its lubricating effect is satisfactory. The results of the investigation imply that the LubriTose SD is a good co-processed excipient with self-lubricating properties, which is promisingly suitable for powder direct compression. |
| doi_str_mv | 10.1016/S1773-2247(12)50097-3 |
| format | Article |
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In this study, the new self-lubricating excipient LubriTose SD was characterized from the aspects of powder technological properties and tableting properties. Micromeritic properties, including particle shape, size distribution, flowability, compressibility, and also the dilution potential were determined. Its applications in powder direct compression have been evaluated, including the effects on flowability, compressibility, the lubricating ability, hygroscopic drugs stability, content uniformity of the low-dose drugs and dissolution of poorly soluble drugs. LubriTose SD is 100 μm with very uniform size distribution and with spherical shape, shows the best flowability, has the same deformation mechanism with the spray-dried monohydrate lactose, has high dilution potential to the hydrophobic drug and has improved function of drug tableting. Its lubricating effect is satisfactory. The results of the investigation imply that the LubriTose SD is a good co-processed excipient with self-lubricating properties, which is promisingly suitable for powder direct compression.</description><identifier>ISSN: 1773-2247</identifier><identifier>DOI: 10.1016/S1773-2247(12)50097-3</identifier><language>eng</language><publisher>Paris: Elsevier B.V</publisher><subject>Biological and medical sciences ; Co-processed excipient ; Compressibility ; Compression ; Direct compression ; Dissolution ; Drug delivery ; General pharmacology ; Hydrophobicity ; Lactose ; LubriTose SD ; Medical sciences ; Micromeritic evaluation ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Powder ; Size distribution</subject><ispartof>Journal of drug delivery science and technology, 2012-01, Vol.22 (6), p.562-567</ispartof><rights>2012 Elsevier B.V.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-c2b0ba1f7fef1edad1a6029c96b48f47ed57bf5a3293289df2addce6368686963</citedby><cites>FETCH-LOGICAL-c372t-c2b0ba1f7fef1edad1a6029c96b48f47ed57bf5a3293289df2addce6368686963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26727281$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, J.-L.</creatorcontrib><creatorcontrib>Tian, C.</creatorcontrib><creatorcontrib>Ke, X.</creatorcontrib><title>Comparative evaluation of a co-processed self-lubricating excipient LubriTose SD as a direct compression vehicle</title><title>Journal of drug delivery science and technology</title><description>LubriTose SD is a new co-processed excipient consisting of spray-dried monohydrate lactose and distilled glyceryl monostearate. In this study, the new self-lubricating excipient LubriTose SD was characterized from the aspects of powder technological properties and tableting properties. Micromeritic properties, including particle shape, size distribution, flowability, compressibility, and also the dilution potential were determined. Its applications in powder direct compression have been evaluated, including the effects on flowability, compressibility, the lubricating ability, hygroscopic drugs stability, content uniformity of the low-dose drugs and dissolution of poorly soluble drugs. LubriTose SD is 100 μm with very uniform size distribution and with spherical shape, shows the best flowability, has the same deformation mechanism with the spray-dried monohydrate lactose, has high dilution potential to the hydrophobic drug and has improved function of drug tableting. Its lubricating effect is satisfactory. The results of the investigation imply that the LubriTose SD is a good co-processed excipient with self-lubricating properties, which is promisingly suitable for powder direct compression.</description><subject>Biological and medical sciences</subject><subject>Co-processed excipient</subject><subject>Compressibility</subject><subject>Compression</subject><subject>Direct compression</subject><subject>Dissolution</subject><subject>Drug delivery</subject><subject>General pharmacology</subject><subject>Hydrophobicity</subject><subject>Lactose</subject><subject>LubriTose SD</subject><subject>Medical sciences</subject><subject>Micromeritic evaluation</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Powder</subject><subject>Size distribution</subject><issn>1773-2247</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqFkE1LxDAQhntQcFn3Jwi5COuhmo9t055E1k9Y8LDrOaTJRCNtU5N20X9vupW9Sg4ThuedYZ4kuSD4mmCS32wJ5yyldMWXhF5lGJc8ZSfJ7Ng-SxYhfGKMCcdkRctZ0q1d00kve7sHBHtZD_HrWuQMkki5tPNOQQigUYDapPVQeasi0r4j-Fa2s9D2aDN2dy4A2t4jGWJSWw-qjwOazsf4OHEPH1bVcJ6cGlkHWPzVefL2-LBbP6eb16eX9d0mVYzTPlW0wpUkhhswBLTUROaYlqrMq1VhVhx0xiuTSUZLRotSGyq1VpCzvIivzNk8WU5z4wVfA4ReNDYoqGvZghuCIIxELisLHtFsQpV3IXgwovO2kf5HECxGseIgVowGBaHiIFawmLv8WyGDkrXxslU2HMM055TTgkTuduIg3ru34EVQ0ZuCyZLQzv6z6ReNw5DG</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Tian, J.-L.</creator><creator>Tian, C.</creator><creator>Ke, X.</creator><general>Elsevier B.V</general><general>Editions de santé</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20120101</creationdate><title>Comparative evaluation of a co-processed self-lubricating excipient LubriTose SD as a direct compression vehicle</title><author>Tian, J.-L. ; Tian, C. ; Ke, X.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-c2b0ba1f7fef1edad1a6029c96b48f47ed57bf5a3293289df2addce6368686963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>Co-processed excipient</topic><topic>Compressibility</topic><topic>Compression</topic><topic>Direct compression</topic><topic>Dissolution</topic><topic>Drug delivery</topic><topic>General pharmacology</topic><topic>Hydrophobicity</topic><topic>Lactose</topic><topic>LubriTose SD</topic><topic>Medical sciences</topic><topic>Micromeritic evaluation</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Powder</topic><topic>Size distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, J.-L.</creatorcontrib><creatorcontrib>Tian, C.</creatorcontrib><creatorcontrib>Ke, X.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of drug delivery science and technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, J.-L.</au><au>Tian, C.</au><au>Ke, X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative evaluation of a co-processed self-lubricating excipient LubriTose SD as a direct compression vehicle</atitle><jtitle>Journal of drug delivery science and technology</jtitle><date>2012-01-01</date><risdate>2012</risdate><volume>22</volume><issue>6</issue><spage>562</spage><epage>567</epage><pages>562-567</pages><issn>1773-2247</issn><abstract>LubriTose SD is a new co-processed excipient consisting of spray-dried monohydrate lactose and distilled glyceryl monostearate. In this study, the new self-lubricating excipient LubriTose SD was characterized from the aspects of powder technological properties and tableting properties. Micromeritic properties, including particle shape, size distribution, flowability, compressibility, and also the dilution potential were determined. Its applications in powder direct compression have been evaluated, including the effects on flowability, compressibility, the lubricating ability, hygroscopic drugs stability, content uniformity of the low-dose drugs and dissolution of poorly soluble drugs. LubriTose SD is 100 μm with very uniform size distribution and with spherical shape, shows the best flowability, has the same deformation mechanism with the spray-dried monohydrate lactose, has high dilution potential to the hydrophobic drug and has improved function of drug tableting. Its lubricating effect is satisfactory. The results of the investigation imply that the LubriTose SD is a good co-processed excipient with self-lubricating properties, which is promisingly suitable for powder direct compression.</abstract><cop>Paris</cop><pub>Elsevier B.V</pub><doi>10.1016/S1773-2247(12)50097-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of drug delivery science and technology, 2012-01, Vol.22 (6), p.562-567 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Biological and medical sciences Co-processed excipient Compressibility Compression Direct compression Dissolution Drug delivery General pharmacology Hydrophobicity Lactose LubriTose SD Medical sciences Micromeritic evaluation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powder Size distribution |
| title | Comparative evaluation of a co-processed self-lubricating excipient LubriTose SD as a direct compression vehicle |
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