Activation of p38 MAPK through transient receptor potential A1 in a rat model of gastric distension-induced visceral pain

Afferent fibers innervating the gastrointestinal tract have major roles in consciously evoked sensations including pain. We reported previously that the activation of ERK1/2, a member of the mitogen-activated protein kinase (MAPK) family, in primary sensory neurons was involved in acute visceral pai...

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Veröffentlicht in:	Neuroreport 2013-01, Vol.24 (2), p.68-72
Hauptverfasser:	Kondo, Takashi, Sakurai, Jun, Miwa, Hiroto, Noguchi, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antisense oligonucleotides Biological and medical sciences Disease Models, Animal Distension Dorsal root ganglia EMG Enzyme Activation Extracellular signal-regulated kinase Fundamental and applied biological sciences. Psychology Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Gastrointestinal tract Hyperalgesia - metabolism Imidazoles - pharmacology Immunohistochemistry Inflammation Ion channels Male MAP kinase Muscles Neurons, Afferent - drug effects Neurons, Afferent - metabolism Neuropathy p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - metabolism Pain Phosphorylation - physiology Pyridines - pharmacology Rats Rats, Sprague-Dawley Sensory neurons Signal Transduction - drug effects Signal Transduction - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors transient receptor potential proteins TRPA1 Cation Channel TRPC Cation Channels - metabolism Vertebrates: nervous system and sense organs Visceral Pain - enzymology Visceral Pain - physiopathology
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