The coagulopathy and thrombotic risk associated with L-Asparaginase treatment in adults with acute lymphoblastic leukaemia

The dramatic improvements seen in the outcome of paediatric patients with acute lymphoblastic leukaemia (ALL) have led to increasing incorporation of L -asparaginase ( L -Asp) in adult treatment protocols. However, its use is associated with a disruption in the physiological balance between haemosta...

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