Antioxidant and immunological activity in vitro of polysaccharides from Gomphidius rutilus mycelium
► Two novel polysaccharide fractions were isolated from Gomphidius rutilus mycelium. ► GRMP1 possessed better antioxidant activity in vitro than GRMP2. ► GRMP1 and GRMP2 have significant lymphocyte proliferation activity. Two novel polysaccharide fractions, GRMP1 and GRMP2, were isolated from the my...
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| Veröffentlicht in: | Carbohydrate polymers 2013-02, Vol.92 (2), p.2187-2192 |
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| creator | Gao, Chanjuan Wang, Yanhua Wang, Chenyu Wang, Zhanyong |
| description | ► Two novel polysaccharide fractions were isolated from Gomphidius rutilus mycelium. ► GRMP1 possessed better antioxidant activity in vitro than GRMP2. ► GRMP1 and GRMP2 have significant lymphocyte proliferation activity.
Two novel polysaccharide fractions, GRMP1 and GRMP2, were isolated from the mycelium of Gomphidius rutilus through submerged fermentation. GRMP1 and GRMP2 had similar average molecular weights (35 and 31kDa, respectively), and were composed of glucose and xylose at molar ratios of 0.46:1 and 0.63:1, respectively. In vitro antioxidant tests showed that GRMP1 and GRMP2 partly scavenged superoxide radical but almost had no scavenging effect on 1,1-diphenyl-2-picrylhydrazyl free radical. The effect of GRMP1 on hydroxyl radicals was stronger than that of GRMP2. Both GRMP1 and GRMP2 had relatively low reducing power and significant lymphocyte proliferation activity. In the presence of concanavalin A or lipopolysaccharide as mitogens for lymphocytes, the lymphocyte proliferation activity increased for GRMP1 but not for GRMP2 within the test dosage range. |
| doi_str_mv | 10.1016/j.carbpol.2012.12.011 |
| format | Article |
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Two novel polysaccharide fractions, GRMP1 and GRMP2, were isolated from the mycelium of Gomphidius rutilus through submerged fermentation. GRMP1 and GRMP2 had similar average molecular weights (35 and 31kDa, respectively), and were composed of glucose and xylose at molar ratios of 0.46:1 and 0.63:1, respectively. In vitro antioxidant tests showed that GRMP1 and GRMP2 partly scavenged superoxide radical but almost had no scavenging effect on 1,1-diphenyl-2-picrylhydrazyl free radical. The effect of GRMP1 on hydroxyl radicals was stronger than that of GRMP2. Both GRMP1 and GRMP2 had relatively low reducing power and significant lymphocyte proliferation activity. In the presence of concanavalin A or lipopolysaccharide as mitogens for lymphocytes, the lymphocyte proliferation activity increased for GRMP1 but not for GRMP2 within the test dosage range.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2012.12.011</identifier><identifier>PMID: 23399275</identifier><identifier>CODEN: CAPOD8</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>2,2-diphenyl-1-picrylhydrazyl ; Adjuvants, Immunologic - chemistry ; Adjuvants, Immunologic - isolation & purification ; Adjuvants, Immunologic - pharmacology ; Animals ; Antioxidant ; Antioxidants ; Applied sciences ; Basidiomycota - chemistry ; Biological and medical sciences ; Carbohydrates ; Cell Proliferation - drug effects ; Concanavalin A ; Exact sciences and technology ; Fermentation ; Free Radical Scavengers - chemistry ; Free Radical Scavengers - isolation & purification ; Free Radical Scavengers - pharmacology ; Free radicals ; General and cellular metabolism. Vitamins ; Glucose ; Gomphidius ; Gomphidius Rutilus ; hydroxyl radicals ; Immunomodulators ; Lipopolysaccharides ; lymphocyte proliferation ; Lymphocytes ; Lymphocytes - cytology ; Lymphocytes - drug effects ; Male ; Medical sciences ; Mice ; Mitogens ; Molecular weight ; Mycelium ; Mycelium - chemistry ; Natural polymers ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Polysaccharide ; Polysaccharides ; Polysaccharides - chemistry ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; Purification ; Starch and polysaccharides ; submerged fermentation ; Superoxide ; superoxide anion ; Xylose</subject><ispartof>Carbohydrate polymers, 2013-02, Vol.92 (2), p.2187-2192</ispartof><rights>2012 Elsevier Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-3038e527911205008e1b2f3ffe3cf054405847364626959bc9ebb54f90c5f5563</citedby><cites>FETCH-LOGICAL-c518t-3038e527911205008e1b2f3ffe3cf054405847364626959bc9ebb54f90c5f5563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2012.12.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26925311$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23399275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Chanjuan</creatorcontrib><creatorcontrib>Wang, Yanhua</creatorcontrib><creatorcontrib>Wang, Chenyu</creatorcontrib><creatorcontrib>Wang, Zhanyong</creatorcontrib><title>Antioxidant and immunological activity in vitro of polysaccharides from Gomphidius rutilus mycelium</title><title>Carbohydrate polymers</title><addtitle>Carbohydr Polym</addtitle><description>► Two novel polysaccharide fractions were isolated from Gomphidius rutilus mycelium. ► GRMP1 possessed better antioxidant activity in vitro than GRMP2. ► GRMP1 and GRMP2 have significant lymphocyte proliferation activity.
Two novel polysaccharide fractions, GRMP1 and GRMP2, were isolated from the mycelium of Gomphidius rutilus through submerged fermentation. GRMP1 and GRMP2 had similar average molecular weights (35 and 31kDa, respectively), and were composed of glucose and xylose at molar ratios of 0.46:1 and 0.63:1, respectively. In vitro antioxidant tests showed that GRMP1 and GRMP2 partly scavenged superoxide radical but almost had no scavenging effect on 1,1-diphenyl-2-picrylhydrazyl free radical. The effect of GRMP1 on hydroxyl radicals was stronger than that of GRMP2. Both GRMP1 and GRMP2 had relatively low reducing power and significant lymphocyte proliferation activity. In the presence of concanavalin A or lipopolysaccharide as mitogens for lymphocytes, the lymphocyte proliferation activity increased for GRMP1 but not for GRMP2 within the test dosage range.</description><subject>2,2-diphenyl-1-picrylhydrazyl</subject><subject>Adjuvants, Immunologic - chemistry</subject><subject>Adjuvants, Immunologic - isolation & purification</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Antioxidant</subject><subject>Antioxidants</subject><subject>Applied sciences</subject><subject>Basidiomycota - chemistry</subject><subject>Biological and medical sciences</subject><subject>Carbohydrates</subject><subject>Cell Proliferation - drug effects</subject><subject>Concanavalin A</subject><subject>Exact sciences and technology</subject><subject>Fermentation</subject><subject>Free Radical Scavengers - chemistry</subject><subject>Free Radical Scavengers - isolation & purification</subject><subject>Free Radical Scavengers - pharmacology</subject><subject>Free radicals</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Glucose</subject><subject>Gomphidius</subject><subject>Gomphidius Rutilus</subject><subject>hydroxyl radicals</subject><subject>Immunomodulators</subject><subject>Lipopolysaccharides</subject><subject>lymphocyte proliferation</subject><subject>Lymphocytes</subject><subject>Lymphocytes - cytology</subject><subject>Lymphocytes - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mitogens</subject><subject>Molecular weight</subject><subject>Mycelium</subject><subject>Mycelium - chemistry</subject><subject>Natural polymers</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Polysaccharide</subject><subject>Polysaccharides</subject><subject>Polysaccharides - chemistry</subject><subject>Polysaccharides - isolation & purification</subject><subject>Polysaccharides - pharmacology</subject><subject>Purification</subject><subject>Starch and polysaccharides</subject><subject>submerged fermentation</subject><subject>Superoxide</subject><subject>superoxide anion</subject><subject>Xylose</subject><issn>0144-8617</issn><issn>1879-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EotuFjwD4gtTLLh7_S3xCVQUFqRIH6NlyHLudVRIvdlKx3x6XXeBYy9K7_N7M6D1C3gDbAgP9Ybf1Lnf7NGw5A76tnwE8IytoG7MBIeVzsmIg5abV0JyR81J2rD4N7CU540IYwxu1Iv5ymjH9wt5NM3VTT3EclykN6Q69G6jzMz7gfKA40ao50RRpXXoozvt7l7EPhcacRnqdxv099rgUmpcZh6rjwYcBl_EVeRHdUMLrk67J7edPP66-bG6-XX-9urzZeAXtvBFMtEHxxgBwphhrA3Q8ihiD8JEpKZlqZSO01FwbZTpvQtcpGQ3zKiqlxZpcHOfuc_q5hDLbEUs9YXBTSEuxIKDVRoIST6O8bUTLFJcVVUfU51RKDtHuM44uHyww-1iF3dlTFfaxiuq1tYrqe3tasXRj6P-5_mZfgfcnwJWadcxu8lj-c9pwJf4MenfkokvW3eXK3H6vm3StU3FdD12Tj0ci1HQfMGRbPIbJhx5z8LPtEz5x7G8sgrLx</recordid><startdate>20130215</startdate><enddate>20130215</enddate><creator>Gao, Chanjuan</creator><creator>Wang, Yanhua</creator><creator>Wang, Chenyu</creator><creator>Wang, Zhanyong</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20130215</creationdate><title>Antioxidant and immunological activity in vitro of polysaccharides from Gomphidius rutilus mycelium</title><author>Gao, Chanjuan ; Wang, Yanhua ; Wang, Chenyu ; Wang, Zhanyong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-3038e527911205008e1b2f3ffe3cf054405847364626959bc9ebb54f90c5f5563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>2,2-diphenyl-1-picrylhydrazyl</topic><topic>Adjuvants, Immunologic - chemistry</topic><topic>Adjuvants, Immunologic - isolation & purification</topic><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Animals</topic><topic>Antioxidant</topic><topic>Antioxidants</topic><topic>Applied sciences</topic><topic>Basidiomycota - chemistry</topic><topic>Biological and medical sciences</topic><topic>Carbohydrates</topic><topic>Cell Proliferation - drug effects</topic><topic>Concanavalin A</topic><topic>Exact sciences and technology</topic><topic>Fermentation</topic><topic>Free Radical Scavengers - chemistry</topic><topic>Free Radical Scavengers - isolation & purification</topic><topic>Free Radical Scavengers - pharmacology</topic><topic>Free radicals</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Glucose</topic><topic>Gomphidius</topic><topic>Gomphidius Rutilus</topic><topic>hydroxyl radicals</topic><topic>Immunomodulators</topic><topic>Lipopolysaccharides</topic><topic>lymphocyte proliferation</topic><topic>Lymphocytes</topic><topic>Lymphocytes - cytology</topic><topic>Lymphocytes - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mitogens</topic><topic>Molecular weight</topic><topic>Mycelium</topic><topic>Mycelium - chemistry</topic><topic>Natural polymers</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Polysaccharide</topic><topic>Polysaccharides</topic><topic>Polysaccharides - chemistry</topic><topic>Polysaccharides - isolation & purification</topic><topic>Polysaccharides - pharmacology</topic><topic>Purification</topic><topic>Starch and polysaccharides</topic><topic>submerged fermentation</topic><topic>Superoxide</topic><topic>superoxide anion</topic><topic>Xylose</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gao, Chanjuan</creatorcontrib><creatorcontrib>Wang, Yanhua</creatorcontrib><creatorcontrib>Wang, Chenyu</creatorcontrib><creatorcontrib>Wang, Zhanyong</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Chanjuan</au><au>Wang, Yanhua</au><au>Wang, Chenyu</au><au>Wang, Zhanyong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant and immunological activity in vitro of polysaccharides from Gomphidius rutilus mycelium</atitle><jtitle>Carbohydrate polymers</jtitle><addtitle>Carbohydr Polym</addtitle><date>2013-02-15</date><risdate>2013</risdate><volume>92</volume><issue>2</issue><spage>2187</spage><epage>2192</epage><pages>2187-2192</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><coden>CAPOD8</coden><abstract>► Two novel polysaccharide fractions were isolated from Gomphidius rutilus mycelium. ► GRMP1 possessed better antioxidant activity in vitro than GRMP2. ► GRMP1 and GRMP2 have significant lymphocyte proliferation activity.
Two novel polysaccharide fractions, GRMP1 and GRMP2, were isolated from the mycelium of Gomphidius rutilus through submerged fermentation. GRMP1 and GRMP2 had similar average molecular weights (35 and 31kDa, respectively), and were composed of glucose and xylose at molar ratios of 0.46:1 and 0.63:1, respectively. In vitro antioxidant tests showed that GRMP1 and GRMP2 partly scavenged superoxide radical but almost had no scavenging effect on 1,1-diphenyl-2-picrylhydrazyl free radical. The effect of GRMP1 on hydroxyl radicals was stronger than that of GRMP2. Both GRMP1 and GRMP2 had relatively low reducing power and significant lymphocyte proliferation activity. In the presence of concanavalin A or lipopolysaccharide as mitogens for lymphocytes, the lymphocyte proliferation activity increased for GRMP1 but not for GRMP2 within the test dosage range.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>23399275</pmid><doi>10.1016/j.carbpol.2012.12.011</doi><tpages>6</tpages></addata></record> |
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| subjects | 2,2-diphenyl-1-picrylhydrazyl Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - isolation & purification Adjuvants, Immunologic - pharmacology Animals Antioxidant Antioxidants Applied sciences Basidiomycota - chemistry Biological and medical sciences Carbohydrates Cell Proliferation - drug effects Concanavalin A Exact sciences and technology Fermentation Free Radical Scavengers - chemistry Free Radical Scavengers - isolation & purification Free Radical Scavengers - pharmacology Free radicals General and cellular metabolism. Vitamins Glucose Gomphidius Gomphidius Rutilus hydroxyl radicals Immunomodulators Lipopolysaccharides lymphocyte proliferation Lymphocytes Lymphocytes - cytology Lymphocytes - drug effects Male Medical sciences Mice Mitogens Molecular weight Mycelium Mycelium - chemistry Natural polymers Pharmacology. Drug treatments Physicochemistry of polymers Polysaccharide Polysaccharides Polysaccharides - chemistry Polysaccharides - isolation & purification Polysaccharides - pharmacology Purification Starch and polysaccharides submerged fermentation Superoxide superoxide anion Xylose |
| title | Antioxidant and immunological activity in vitro of polysaccharides from Gomphidius rutilus mycelium |
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