Systems-Based Discovery Advances Drug Development
Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on t...
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| Veröffentlicht in: | Clinical pharmacology and therapeutics 2013-04, Vol.93 (4), p.285-287 |
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| container_title | Clinical pharmacology and therapeutics |
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| creator | Waldman, S A Terzic, A |
| description | Drug development expenditures continue to escalate, in part reflecting inefficiencies in current drug discovery paradigms. Traditional drug discovery has been dichotomous, focusing either on phenotypic effects of distinct agents in biological systems, without knowledge of respective targets, or on target‐based activities of specific molecules in cell‐free assays. Driven by advances in biology, engineering, and informatics, new paradigms integrate phenotypic with target‐based algorithms into comprehensive, systems‐level approaches offering value‐added strategies for optimized drug discovery.
Clinical Pharmacology & Therapeutics (2013); 93 4, 285–287. doi:10.1038/clpt.2013.21 |
| doi_str_mv | 10.1038/clpt.2013.21 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Clinical pharmacology and therapeutics, 2013-04, Vol.93 (4), p.285-287 |
| issn | 0009-9236 1532-6535 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1318692950 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Drug Discovery - methods Humans Systems Biology - methods |
| title | Systems-Based Discovery Advances Drug Development |
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