Safety assessment of oral photodynamic therapy in rats
Photodynamic therapy (PDT) is based on the synergism of a photosensitive drug (a photosensitizer) and visible light to destroy target cells (e.g., malignant, premalignant, or bacterial cells). The aim of this study was to investigate the response of normal rat tongue mucosa to PDT following the topi...
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| Veröffentlicht in: | Lasers in medical science 2013-02, Vol.28 (2), p.479-486 |
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| creator | Fontana, Carla R. Lerman, Mark A. Patel, Niraj Grecco, Clovis de Souza Costa, Carlos A. Amiji, Mansoor M. Bagnato, Vanderlei S. Soukos, Nikolaos S. |
| description | Photodynamic therapy (PDT) is based on the synergism of a photosensitive drug (a photosensitizer) and visible light to destroy target cells (e.g., malignant, premalignant, or bacterial cells). The aim of this study was to investigate the response of normal rat tongue mucosa to PDT following the topical application of hematoporphyrin derivative (Photogem®), Photodithazine®, methylene blue (MB), and poly(lactic-
co
-glycolic acid) (PLGA) nanoparticles loaded with MB. One hundred and thirty three rats were randomly divided in various groups: the PDT groups were treated with the photosensitizers for 10 min followed by exposure to red light. Those in control groups received neither photosensitizer nor light, and they were subjected to light exposure alone or to photosensitizer alone. Fluorescent signals were obtained from tongue tissue immediately after the topical application of photosensitizers and 24 h following PDT. Histological changes were evaluated at baseline and at 1, 3, 7, and 15 days post-PDT treatment. Fluorescence was detected immediately after the application of the photosensitizers, but not 24 h following PDT. Histology revealed intact mucosa in all experimental groups at all evaluation time points. The results suggest that there is a therapeutic window where PDT with Photogem®, Photodithazine®, MB, and MB-loaded PLGA nanoparticles could safely target oral pathogenic bacteria without damaging normal oral tissue. |
| doi_str_mv | 10.1007/s10103-012-1091-6 |
| format | Article |
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co
-glycolic acid) (PLGA) nanoparticles loaded with MB. One hundred and thirty three rats were randomly divided in various groups: the PDT groups were treated with the photosensitizers for 10 min followed by exposure to red light. Those in control groups received neither photosensitizer nor light, and they were subjected to light exposure alone or to photosensitizer alone. Fluorescent signals were obtained from tongue tissue immediately after the topical application of photosensitizers and 24 h following PDT. Histological changes were evaluated at baseline and at 1, 3, 7, and 15 days post-PDT treatment. Fluorescence was detected immediately after the application of the photosensitizers, but not 24 h following PDT. Histology revealed intact mucosa in all experimental groups at all evaluation time points. The results suggest that there is a therapeutic window where PDT with Photogem®, Photodithazine®, MB, and MB-loaded PLGA nanoparticles could safely target oral pathogenic bacteria without damaging normal oral tissue.</description><identifier>ISSN: 0268-8921</identifier><identifier>EISSN: 1435-604X</identifier><identifier>DOI: 10.1007/s10103-012-1091-6</identifier><identifier>PMID: 22467011</identifier><identifier>CODEN: LMSCEZ</identifier><language>eng</language><publisher>London: Springer-Verlag</publisher><subject><![CDATA[Administration, Oral ; Animals ; Dentistry ; Fluorescence ; Glucosamine - administration & dosage ; Glucosamine - analogs & derivatives ; Glucosamine - pharmacology ; Hematoporphyrin Derivative - administration & dosage ; Hematoporphyrin Derivative - pharmacology ; Histology ; Lactic Acid - administration & dosage ; Lactic Acid - pharmacology ; Lasers ; Male ; Medicine ; Medicine & Public Health ; Methylene Blue - administration & dosage ; Methylene Blue - therapeutic use ; Mouth Mucosa - cytology ; Mouth Mucosa - drug effects ; Mouth Mucosa - radiation effects ; Nanoparticles - administration & dosage ; Optical Devices ; Optics ; Original Article ; Photochemotherapy - adverse effects ; Photochemotherapy - methods ; Photodynamic therapy ; Photonics ; Photosensitizing Agents - administration & dosage ; Photosensitizing Agents - therapeutic use ; Polyglycolic Acid - administration & dosage ; Polyglycolic Acid - pharmacology ; Quantum Optics ; Rats ; Rats, Wistar ; Rodents ; Safety ; Tongue]]></subject><ispartof>Lasers in medical science, 2013-02, Vol.28 (2), p.479-486</ispartof><rights>Springer-Verlag London Ltd 2012</rights><rights>Springer-Verlag London 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-e0393f51ba24c14be42d2c1e0d3e3f085190ee05b857fd9a1b3d33d6f704eda3</citedby><cites>FETCH-LOGICAL-c405t-e0393f51ba24c14be42d2c1e0d3e3f085190ee05b857fd9a1b3d33d6f704eda3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10103-012-1091-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10103-012-1091-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22467011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fontana, Carla R.</creatorcontrib><creatorcontrib>Lerman, Mark A.</creatorcontrib><creatorcontrib>Patel, Niraj</creatorcontrib><creatorcontrib>Grecco, Clovis</creatorcontrib><creatorcontrib>de Souza Costa, Carlos A.</creatorcontrib><creatorcontrib>Amiji, Mansoor M.</creatorcontrib><creatorcontrib>Bagnato, Vanderlei S.</creatorcontrib><creatorcontrib>Soukos, Nikolaos S.</creatorcontrib><title>Safety assessment of oral photodynamic therapy in rats</title><title>Lasers in medical science</title><addtitle>Lasers Med Sci</addtitle><addtitle>Lasers Med Sci</addtitle><description>Photodynamic therapy (PDT) is based on the synergism of a photosensitive drug (a photosensitizer) and visible light to destroy target cells (e.g., malignant, premalignant, or bacterial cells). The aim of this study was to investigate the response of normal rat tongue mucosa to PDT following the topical application of hematoporphyrin derivative (Photogem®), Photodithazine®, methylene blue (MB), and poly(lactic-
co
-glycolic acid) (PLGA) nanoparticles loaded with MB. One hundred and thirty three rats were randomly divided in various groups: the PDT groups were treated with the photosensitizers for 10 min followed by exposure to red light. Those in control groups received neither photosensitizer nor light, and they were subjected to light exposure alone or to photosensitizer alone. Fluorescent signals were obtained from tongue tissue immediately after the topical application of photosensitizers and 24 h following PDT. Histological changes were evaluated at baseline and at 1, 3, 7, and 15 days post-PDT treatment. Fluorescence was detected immediately after the application of the photosensitizers, but not 24 h following PDT. Histology revealed intact mucosa in all experimental groups at all evaluation time points. The results suggest that there is a therapeutic window where PDT with Photogem®, Photodithazine®, MB, and MB-loaded PLGA nanoparticles could safely target oral pathogenic bacteria without damaging normal oral tissue.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Dentistry</subject><subject>Fluorescence</subject><subject>Glucosamine - administration & dosage</subject><subject>Glucosamine - analogs & derivatives</subject><subject>Glucosamine - pharmacology</subject><subject>Hematoporphyrin Derivative - administration & dosage</subject><subject>Hematoporphyrin Derivative - pharmacology</subject><subject>Histology</subject><subject>Lactic Acid - administration & dosage</subject><subject>Lactic Acid - pharmacology</subject><subject>Lasers</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylene Blue - administration & dosage</subject><subject>Methylene Blue - therapeutic use</subject><subject>Mouth Mucosa - cytology</subject><subject>Mouth Mucosa - drug effects</subject><subject>Mouth Mucosa - radiation effects</subject><subject>Nanoparticles - administration & dosage</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Original Article</subject><subject>Photochemotherapy - adverse effects</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photonics</subject><subject>Photosensitizing Agents - administration & dosage</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Polyglycolic Acid - administration & dosage</subject><subject>Polyglycolic Acid - pharmacology</subject><subject>Quantum Optics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Safety</subject><subject>Tongue</subject><issn>0268-8921</issn><issn>1435-604X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kD1PwzAQhi0EoqXwA1hQJBaWwJ3tOMmIKr6kSgx0YLOc5EJT5Qs7GfrvcZWCEBLTDfe8750exi4RbhEgvnMICCIE5CFCiqE6YnOUIgoVyPdjNgeukjBJOc7YmXNbAIwVilM241yqGBDnTL2ZkoZdYJwj5xpqh6Arg86aOug33dAVu9Y0VR4MG7Km3wVVG1gzuHN2Upra0cVhLtj68WG9fA5Xr08vy_tVmEuIhpBApKKMMDNc5igzkrzgORIUgkQJSYQpEEGUJVFcFqnBTBRCFKqMQVJhxILdTLW97T5HcoNuKpdTXZuWutFpFJiolMs08ej1H3Tbjbb1z-0p_00MIvYUTlRuO-cslbq3VWPsTiPovVM9OdXeqd471cpnrg7NY9ZQ8ZP4lugBPgHOr9oPsr9O_9v6BZ2HgBE</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Fontana, Carla R.</creator><creator>Lerman, Mark A.</creator><creator>Patel, Niraj</creator><creator>Grecco, Clovis</creator><creator>de Souza Costa, Carlos A.</creator><creator>Amiji, Mansoor M.</creator><creator>Bagnato, Vanderlei S.</creator><creator>Soukos, Nikolaos S.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7SP</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>L7M</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20130201</creationdate><title>Safety assessment of oral photodynamic therapy in rats</title><author>Fontana, Carla R. ; Lerman, Mark A. ; Patel, Niraj ; Grecco, Clovis ; de Souza Costa, Carlos A. ; Amiji, Mansoor M. ; Bagnato, Vanderlei S. ; Soukos, Nikolaos S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-e0393f51ba24c14be42d2c1e0d3e3f085190ee05b857fd9a1b3d33d6f704eda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Dentistry</topic><topic>Fluorescence</topic><topic>Glucosamine - 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The aim of this study was to investigate the response of normal rat tongue mucosa to PDT following the topical application of hematoporphyrin derivative (Photogem®), Photodithazine®, methylene blue (MB), and poly(lactic-
co
-glycolic acid) (PLGA) nanoparticles loaded with MB. One hundred and thirty three rats were randomly divided in various groups: the PDT groups were treated with the photosensitizers for 10 min followed by exposure to red light. Those in control groups received neither photosensitizer nor light, and they were subjected to light exposure alone or to photosensitizer alone. Fluorescent signals were obtained from tongue tissue immediately after the topical application of photosensitizers and 24 h following PDT. Histological changes were evaluated at baseline and at 1, 3, 7, and 15 days post-PDT treatment. Fluorescence was detected immediately after the application of the photosensitizers, but not 24 h following PDT. Histology revealed intact mucosa in all experimental groups at all evaluation time points. The results suggest that there is a therapeutic window where PDT with Photogem®, Photodithazine®, MB, and MB-loaded PLGA nanoparticles could safely target oral pathogenic bacteria without damaging normal oral tissue.</abstract><cop>London</cop><pub>Springer-Verlag</pub><pmid>22467011</pmid><doi>10.1007/s10103-012-1091-6</doi><tpages>8</tpages></addata></record> |
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| subjects | Administration, Oral Animals Dentistry Fluorescence Glucosamine - administration & dosage Glucosamine - analogs & derivatives Glucosamine - pharmacology Hematoporphyrin Derivative - administration & dosage Hematoporphyrin Derivative - pharmacology Histology Lactic Acid - administration & dosage Lactic Acid - pharmacology Lasers Male Medicine Medicine & Public Health Methylene Blue - administration & dosage Methylene Blue - therapeutic use Mouth Mucosa - cytology Mouth Mucosa - drug effects Mouth Mucosa - radiation effects Nanoparticles - administration & dosage Optical Devices Optics Original Article Photochemotherapy - adverse effects Photochemotherapy - methods Photodynamic therapy Photonics Photosensitizing Agents - administration & dosage Photosensitizing Agents - therapeutic use Polyglycolic Acid - administration & dosage Polyglycolic Acid - pharmacology Quantum Optics Rats Rats, Wistar Rodents Safety Tongue |
| title | Safety assessment of oral photodynamic therapy in rats |
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