Effect of host defenses on Clostridium difficile toxin-induced intestinal barrier injury

The severity of Clostridium difficile-associated infection depends on the virulence factors of the organism and host factors, including intestinal barrier function. The intestinal mucus layer has recently been recognized as the first line of defense against enteric pathogens. Its interaction with mu...

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Veröffentlicht in:	The journal of trauma and acute care surgery 2013-04, Vol.74 (4), p.983-990
Hauptverfasser:	Olson, Alicia, Diebel, Lawrence N, Liberati, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins Bacterial Toxins - metabolism Biological Transport Clostridium difficile - pathogenicity Enterotoxins - metabolism Enterotoxins - secretion Enzyme-Linked Immunosorbent Assay HT29 Cells Humans Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Secretory Component - metabolism
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