An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana
Summary In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor ‘Regulator of Proteasomal Gene Expression’ (RPX) controls leaf size by positively modulating proteasome acti...
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| Veröffentlicht in: | The Plant journal : for cell and molecular biology 2013-04, Vol.74 (1), p.25-36 |
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| container_title | The Plant journal : for cell and molecular biology |
| container_volume | 74 |
| creator | Nguyen, Hung M. Schippers, Jos H. M. Gõni‐Ramos, Oscar Christoph, Mathias P. Dortay, Hakan Hoorn, Renier A. L. Mueller‐Roeber, Bernd |
| description | Summary
In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor ‘Regulator of Proteasomal Gene Expression’ (RPX) controls leaf size by positively modulating proteasome activity. We further show that the cis‐element recognized by RPX is evolutionarily conserved between higher plant species. Upon over‐expression of RPX, plants exhibit reduced growth, which may be reversed by a low concentration of the pharmacological proteasome inhibitor MG132. These data suggest that the rate of protein turnover during growth is a critical parameter for determining final organ size. |
| doi_str_mv | 10.1111/tpj.12097 |
| format | Article |
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In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor ‘Regulator of Proteasomal Gene Expression’ (RPX) controls leaf size by positively modulating proteasome activity. We further show that the cis‐element recognized by RPX is evolutionarily conserved between higher plant species. Upon over‐expression of RPX, plants exhibit reduced growth, which may be reversed by a low concentration of the pharmacological proteasome inhibitor MG132. These data suggest that the rate of protein turnover during growth is a critical parameter for determining final organ size.</description><identifier>ISSN: 0960-7412</identifier><identifier>EISSN: 1365-313X</identifier><identifier>DOI: 10.1111/tpj.12097</identifier><identifier>PMID: 23252408</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Arabidopsis - genetics ; Arabidopsis - growth & development ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Arabidopsis thaliana ; DNA, Bacterial ; evolution ; Gene expression ; Gene Expression Regulation, Plant ; Gene Knockout Techniques ; gene regulatory network ; Gene Regulatory Networks ; leaf development ; Leupeptins ; Mutagenesis, Insertional ; organ size ; Plant growth ; Plant Leaves - growth & development ; Plant Roots - growth & development ; Plant sciences ; Plants, Genetically Modified - growth & development ; Promoter Regions, Genetic ; Proteases ; proteasome ; Proteasome Endopeptidase Complex - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>The Plant journal : for cell and molecular biology, 2013-04, Vol.74 (1), p.25-36</ispartof><rights>2012 The Authors The Plant Journal © 2012 Blackwell Publishing Ltd</rights><rights>2012 The Authors The Plant Journal © 2012 Blackwell Publishing Ltd.</rights><rights>Copyright © 2013 Blackwell Publishing Ltd and the Society for Experimental Biology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftpj.12097$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftpj.12097$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23252408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Hung M.</creatorcontrib><creatorcontrib>Schippers, Jos H. M.</creatorcontrib><creatorcontrib>Gõni‐Ramos, Oscar</creatorcontrib><creatorcontrib>Christoph, Mathias P.</creatorcontrib><creatorcontrib>Dortay, Hakan</creatorcontrib><creatorcontrib>Hoorn, Renier A. L.</creatorcontrib><creatorcontrib>Mueller‐Roeber, Bernd</creatorcontrib><title>An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana</title><title>The Plant journal : for cell and molecular biology</title><addtitle>Plant J</addtitle><description>Summary
In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor ‘Regulator of Proteasomal Gene Expression’ (RPX) controls leaf size by positively modulating proteasome activity. We further show that the cis‐element recognized by RPX is evolutionarily conserved between higher plant species. Upon over‐expression of RPX, plants exhibit reduced growth, which may be reversed by a low concentration of the pharmacological proteasome inhibitor MG132. These data suggest that the rate of protein turnover during growth is a critical parameter for determining final organ size.</description><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - growth & development</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Arabidopsis thaliana</subject><subject>DNA, Bacterial</subject><subject>evolution</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Plant</subject><subject>Gene Knockout Techniques</subject><subject>gene regulatory network</subject><subject>Gene Regulatory Networks</subject><subject>leaf development</subject><subject>Leupeptins</subject><subject>Mutagenesis, Insertional</subject><subject>organ size</subject><subject>Plant growth</subject><subject>Plant Leaves - growth & development</subject><subject>Plant Roots - growth & development</subject><subject>Plant sciences</subject><subject>Plants, Genetically Modified - growth & development</subject><subject>Promoter Regions, Genetic</subject><subject>Proteases</subject><subject>proteasome</subject><subject>Proteasome Endopeptidase Complex - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0960-7412</issn><issn>1365-313X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1Lw0AQhhdRbK0e_AOy4MVL7H5vcizFTwoKVuht2TSbuiXJxt0Eqb_e7YcenMsMzDPDO_MCcInRLY4x7tr1LSYok0dgiKngCcV0cQyGKBMokQyTATgLYY0QllSwUzAglHDCUDoEi0kD-zZ03ugaerPqK905D10Juw8DiXiDrXed0cHVBtau2PZNgM6vdAOD_TbQNnDidW4L1wYb4piurG70OTgpdRXMxSGPwPv93Xz6mMxeHp6mk1mypimSCcMaEZ1JyVhB8my5lJwKnEkkTK5RzhHLJS0IF7gkSPAyLXikWFHgeIDgko7AzX5v1PnZm9Cp2oalqSrdGNcHhSlORYYkyyJ6_Q9du943Ud2WkoJgjtJIXR2oPq9NoVpva-036vdnERjvgS9bmc1fHyO1NUNFM9TODDV_fd4V9Achv3ns</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Nguyen, Hung M.</creator><creator>Schippers, Jos H. M.</creator><creator>Gõni‐Ramos, Oscar</creator><creator>Christoph, Mathias P.</creator><creator>Dortay, Hakan</creator><creator>Hoorn, Renier A. L.</creator><creator>Mueller‐Roeber, Bernd</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana</title><author>Nguyen, Hung M. ; Schippers, Jos H. M. ; Gõni‐Ramos, Oscar ; Christoph, Mathias P. ; Dortay, Hakan ; Hoorn, Renier A. L. ; Mueller‐Roeber, Bernd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j3807-41a02a97744d2b9cc753619706eba0b504b73d2561f2065f8d5b9c4dd15246573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - growth & development</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Arabidopsis thaliana</topic><topic>DNA, Bacterial</topic><topic>evolution</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Plant</topic><topic>Gene Knockout Techniques</topic><topic>gene regulatory network</topic><topic>Gene Regulatory Networks</topic><topic>leaf development</topic><topic>Leupeptins</topic><topic>Mutagenesis, Insertional</topic><topic>organ size</topic><topic>Plant growth</topic><topic>Plant Leaves - growth & development</topic><topic>Plant Roots - growth & development</topic><topic>Plant sciences</topic><topic>Plants, Genetically Modified - growth & development</topic><topic>Promoter Regions, Genetic</topic><topic>Proteases</topic><topic>proteasome</topic><topic>Proteasome Endopeptidase Complex - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Hung M.</creatorcontrib><creatorcontrib>Schippers, Jos H. 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In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor ‘Regulator of Proteasomal Gene Expression’ (RPX) controls leaf size by positively modulating proteasome activity. We further show that the cis‐element recognized by RPX is evolutionarily conserved between higher plant species. Upon over‐expression of RPX, plants exhibit reduced growth, which may be reversed by a low concentration of the pharmacological proteasome inhibitor MG132. These data suggest that the rate of protein turnover during growth is a critical parameter for determining final organ size.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>23252408</pmid><doi>10.1111/tpj.12097</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; IngentaConnect Free/Open Access Journals; Wiley Online Library All Journals |
| subjects | Arabidopsis - genetics Arabidopsis - growth & development Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana DNA, Bacterial evolution Gene expression Gene Expression Regulation, Plant Gene Knockout Techniques gene regulatory network Gene Regulatory Networks leaf development Leupeptins Mutagenesis, Insertional organ size Plant growth Plant Leaves - growth & development Plant Roots - growth & development Plant sciences Plants, Genetically Modified - growth & development Promoter Regions, Genetic Proteases proteasome Proteasome Endopeptidase Complex - metabolism Transcription Factors - genetics Transcription Factors - metabolism |
| title | An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana |
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