Homeopathic mother tincture of Phytolacca decandra induces apoptosis in skin melanoma cells by activating caspase-mediated signaling via reactive oxygen species elevation

OBJECTIVE： Preventive measures against skin melanoma like chemotherapy are useful but suffer from chronic side effects and drug resistance. Ethanolic extract of Phytolacca decandra （PD）, used in homeopathy for the treatment of various ailments like chronic rheumatism, regular conjunctivitis, psorias...

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Veröffentlicht in:	Journal of integrative medicine 2013-03, Vol.11 (2), p.116-124
Hauptverfasser:	Ghosh, Samrat, Bishayee, Kausik, Paul, Avijit, Mukherjee, Avinaba, Sikdar, Sourav, Chakraborty, Debrup, Boujedaini, Naoual, Khuda-Bukhsh, Anisur Rahman
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology apoptosis Apoptosis - drug effects Caspase 3 - genetics Caspase 3 - metabolism Cell Line, Tumor Drugs, Chinese Herbal - pharmacology gene expression Gene Expression Regulation, Neoplastic - drug effects Humans Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Melanoma - physiopathology Phytolacca - chemistry Phytolacca decandra Phytotherapy Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction - drug effects skin neoplasms Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism Skin Neoplasms - physiopathology Up-Regulation - drug effects 介导信号半胱天冬酶活性氧激活皮肤疾病细胞凋亡黑色素瘤
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