Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence
BACKGROUND: In head and neck cancer (HNC), 3‐month post‐treatment positron emission tomography (PET)/computed tomography (CT) reliably identifies persistent/recurrent disease. However, further PET/CT surveillance has unclear benefit. The impact of post‐treatment PET/CT surveillance on outcomes is as...
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| Veröffentlicht in: | Cancer 2013-04, Vol.119 (7), p.1349-1356 |
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| creator | Ho, Allen S. Tsao, Gabriel J. Chen, Frank W. Shen, Tianjie Kaplan, Michael J. Colevas, A. Dimitrios Fischbein, Nancy J. Quon, Andrew Le, Quynh‐Thu Pinto, Harlan A. Fee, Willard E. Sunwoo, John B. Sirjani, Davud Hara, Wendy Yao, Mike |
| description | BACKGROUND:
In head and neck cancer (HNC), 3‐month post‐treatment positron emission tomography (PET)/computed tomography (CT) reliably identifies persistent/recurrent disease. However, further PET/CT surveillance has unclear benefit. The impact of post‐treatment PET/CT surveillance on outcomes is assessed at 12 and 24 months.
METHODS:
A 10‐year retrospective analysis of HNC patients was carried out with long‐term serial imaging. Imaging at 3 months included either PET/CT or magnetic resonance imaging, with all subsequent imaging comprised of PET/CT. PET/CT scans at 12 and 24 months were evaluated only if preceding interval scans were negative. Of 1114 identified patients, 284 had 3‐month scans, 175 had 3‐ and 12‐month scans, and 77 had 3‐, 12‐, and 24‐month scans.
RESULTS:
PET/CT detection rates in clinically occult patients were 9% (15 of 175) at 12 months, and 4% (3 of 77) at 24 months. No difference in outcomes was identified between PET/CT‐detected and clinically detected recurrences, with similar 3‐year disease‐free survival (41% vs 46%, P = .91) and 3‐year overall survival (60% vs 54%, P = .70) rates. Compared with 3‐month PET/CT, 12‐month PET/CT demonstrated fewer equivocal reads (26% vs 10%, P < .001). Of scans deemed equivocal, 6% (5 of 89) were ultimately found to be positive.
CONCLUSIONS:
HNC patients with negative 3‐month imaging appear to derive limited benefit from subsequent PET/CT surveillance. No survival differences were observed between PET/CT‐detected and clinically detected recurrences, although larger prospective studies are needed for further investigation. Cancer 2013. © 2012 American Cancer Society.
Surveillance 12‐ and 24‐month post‐treatment positron emission tomography/computed tomography (PET/CT) scans are of limited yield in head and neck cancer patients with negative 3‐month imaging. No survival differences are observed between PET/CT‐detected and clinically detected recurrences. |
| doi_str_mv | 10.1002/cncr.27892 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1318093442</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1318093442</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4252-d9898d3753bbecafce7659694eafa71ba807cf58f47f54837633142e0de980373</originalsourceid><addsrcrecordid>eNp9kEtrGzEQgEVJaNwkl_yAoEuhFDbR05KOxaStITQQEshtkbWjeJPd1VbStvgn9F9Xjt3HKad58M0M8yF0RskFJYRdusHFC6a0YW_QjBKjKkIFO0AzQoiupOAPR-hdSk-lVEzyt-iIccakFGKGfi370bqMg8djSG2OYcDQtym1JcmhD4_RjuvNpQv9OGVo_uvhNMUf0HadHRxgmzFl2A4NZgL3YcjrhH2IuIEMLrfDI16DbV6AAdwzdtupiCO4KUYo-Qk69LZLcLqPx-j-89Xd4mt1ffNlufh0XTnBJKsao41uuJJ8tQJnvQM1l2ZuBFhvFV1ZTZTzUnuhvBSaqznnxQaQBowmXPFj9GG3d4zh-wQp1-VdB9s3IEypppxqYrgQrKAfd6iLIaUIvh5j29u4qSmpt-rrrfr6RX2Bz_d7p1UPzV_0j-sCvN8DNjnb-VgMtOkfpyiX3MjC0R33s-1g88rJevFtcbs7_hueGJ1e</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1318093442</pqid></control><display><type>article</type><title>Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Online Library Free Content</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Ho, Allen S. ; Tsao, Gabriel J. ; Chen, Frank W. ; Shen, Tianjie ; Kaplan, Michael J. ; Colevas, A. Dimitrios ; Fischbein, Nancy J. ; Quon, Andrew ; Le, Quynh‐Thu ; Pinto, Harlan A. ; Fee, Willard E. ; Sunwoo, John B. ; Sirjani, Davud ; Hara, Wendy ; Yao, Mike</creator><creatorcontrib>Ho, Allen S. ; Tsao, Gabriel J. ; Chen, Frank W. ; Shen, Tianjie ; Kaplan, Michael J. ; Colevas, A. Dimitrios ; Fischbein, Nancy J. ; Quon, Andrew ; Le, Quynh‐Thu ; Pinto, Harlan A. ; Fee, Willard E. ; Sunwoo, John B. ; Sirjani, Davud ; Hara, Wendy ; Yao, Mike</creatorcontrib><description>BACKGROUND:
In head and neck cancer (HNC), 3‐month post‐treatment positron emission tomography (PET)/computed tomography (CT) reliably identifies persistent/recurrent disease. However, further PET/CT surveillance has unclear benefit. The impact of post‐treatment PET/CT surveillance on outcomes is assessed at 12 and 24 months.
METHODS:
A 10‐year retrospective analysis of HNC patients was carried out with long‐term serial imaging. Imaging at 3 months included either PET/CT or magnetic resonance imaging, with all subsequent imaging comprised of PET/CT. PET/CT scans at 12 and 24 months were evaluated only if preceding interval scans were negative. Of 1114 identified patients, 284 had 3‐month scans, 175 had 3‐ and 12‐month scans, and 77 had 3‐, 12‐, and 24‐month scans.
RESULTS:
PET/CT detection rates in clinically occult patients were 9% (15 of 175) at 12 months, and 4% (3 of 77) at 24 months. No difference in outcomes was identified between PET/CT‐detected and clinically detected recurrences, with similar 3‐year disease‐free survival (41% vs 46%, P = .91) and 3‐year overall survival (60% vs 54%, P = .70) rates. Compared with 3‐month PET/CT, 12‐month PET/CT demonstrated fewer equivocal reads (26% vs 10%, P < .001). Of scans deemed equivocal, 6% (5 of 89) were ultimately found to be positive.
CONCLUSIONS:
HNC patients with negative 3‐month imaging appear to derive limited benefit from subsequent PET/CT surveillance. No survival differences were observed between PET/CT‐detected and clinically detected recurrences, although larger prospective studies are needed for further investigation. Cancer 2013. © 2012 American Cancer Society.
Surveillance 12‐ and 24‐month post‐treatment positron emission tomography/computed tomography (PET/CT) scans are of limited yield in head and neck cancer patients with negative 3‐month imaging. No survival differences are observed between PET/CT‐detected and clinically detected recurrences.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.27892</identifier><identifier>PMID: 23225544</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - diagnosis ; computed tomography ; Female ; head and neck cancer ; Head and Neck Neoplasms - diagnosis ; Humans ; integrated positron emission tomography and computed tomography ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Multimodal Imaging ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Positron-Emission Tomography ; Recurrence ; Retrospective Studies ; salvage therapy ; Squamous Cell Carcinoma of Head and Neck ; surveillance ; Time Factors ; Tomography, X-Ray Computed ; Tumors ; Young Adult</subject><ispartof>Cancer, 2013-04, Vol.119 (7), p.1349-1356</ispartof><rights>Copyright © 2012 American Cancer Society</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 American Cancer Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4252-d9898d3753bbecafce7659694eafa71ba807cf58f47f54837633142e0de980373</citedby><cites>FETCH-LOGICAL-c4252-d9898d3753bbecafce7659694eafa71ba807cf58f47f54837633142e0de980373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.27892$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.27892$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27135395$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23225544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ho, Allen S.</creatorcontrib><creatorcontrib>Tsao, Gabriel J.</creatorcontrib><creatorcontrib>Chen, Frank W.</creatorcontrib><creatorcontrib>Shen, Tianjie</creatorcontrib><creatorcontrib>Kaplan, Michael J.</creatorcontrib><creatorcontrib>Colevas, A. Dimitrios</creatorcontrib><creatorcontrib>Fischbein, Nancy J.</creatorcontrib><creatorcontrib>Quon, Andrew</creatorcontrib><creatorcontrib>Le, Quynh‐Thu</creatorcontrib><creatorcontrib>Pinto, Harlan A.</creatorcontrib><creatorcontrib>Fee, Willard E.</creatorcontrib><creatorcontrib>Sunwoo, John B.</creatorcontrib><creatorcontrib>Sirjani, Davud</creatorcontrib><creatorcontrib>Hara, Wendy</creatorcontrib><creatorcontrib>Yao, Mike</creatorcontrib><title>Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND:
In head and neck cancer (HNC), 3‐month post‐treatment positron emission tomography (PET)/computed tomography (CT) reliably identifies persistent/recurrent disease. However, further PET/CT surveillance has unclear benefit. The impact of post‐treatment PET/CT surveillance on outcomes is assessed at 12 and 24 months.
METHODS:
A 10‐year retrospective analysis of HNC patients was carried out with long‐term serial imaging. Imaging at 3 months included either PET/CT or magnetic resonance imaging, with all subsequent imaging comprised of PET/CT. PET/CT scans at 12 and 24 months were evaluated only if preceding interval scans were negative. Of 1114 identified patients, 284 had 3‐month scans, 175 had 3‐ and 12‐month scans, and 77 had 3‐, 12‐, and 24‐month scans.
RESULTS:
PET/CT detection rates in clinically occult patients were 9% (15 of 175) at 12 months, and 4% (3 of 77) at 24 months. No difference in outcomes was identified between PET/CT‐detected and clinically detected recurrences, with similar 3‐year disease‐free survival (41% vs 46%, P = .91) and 3‐year overall survival (60% vs 54%, P = .70) rates. Compared with 3‐month PET/CT, 12‐month PET/CT demonstrated fewer equivocal reads (26% vs 10%, P < .001). Of scans deemed equivocal, 6% (5 of 89) were ultimately found to be positive.
CONCLUSIONS:
HNC patients with negative 3‐month imaging appear to derive limited benefit from subsequent PET/CT surveillance. No survival differences were observed between PET/CT‐detected and clinically detected recurrences, although larger prospective studies are needed for further investigation. Cancer 2013. © 2012 American Cancer Society.
Surveillance 12‐ and 24‐month post‐treatment positron emission tomography/computed tomography (PET/CT) scans are of limited yield in head and neck cancer patients with negative 3‐month imaging. No survival differences are observed between PET/CT‐detected and clinically detected recurrences.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>computed tomography</subject><subject>Female</subject><subject>head and neck cancer</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Humans</subject><subject>integrated positron emission tomography and computed tomography</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multimodal Imaging</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Positron-Emission Tomography</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>salvage therapy</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>surveillance</subject><subject>Time Factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrGzEQgEVJaNwkl_yAoEuhFDbR05KOxaStITQQEshtkbWjeJPd1VbStvgn9F9Xjt3HKad58M0M8yF0RskFJYRdusHFC6a0YW_QjBKjKkIFO0AzQoiupOAPR-hdSk-lVEzyt-iIccakFGKGfi370bqMg8djSG2OYcDQtym1JcmhD4_RjuvNpQv9OGVo_uvhNMUf0HadHRxgmzFl2A4NZgL3YcjrhH2IuIEMLrfDI16DbV6AAdwzdtupiCO4KUYo-Qk69LZLcLqPx-j-89Xd4mt1ffNlufh0XTnBJKsao41uuJJ8tQJnvQM1l2ZuBFhvFV1ZTZTzUnuhvBSaqznnxQaQBowmXPFj9GG3d4zh-wQp1-VdB9s3IEypppxqYrgQrKAfd6iLIaUIvh5j29u4qSmpt-rrrfr6RX2Bz_d7p1UPzV_0j-sCvN8DNjnb-VgMtOkfpyiX3MjC0R33s-1g88rJevFtcbs7_hueGJ1e</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Ho, Allen S.</creator><creator>Tsao, Gabriel J.</creator><creator>Chen, Frank W.</creator><creator>Shen, Tianjie</creator><creator>Kaplan, Michael J.</creator><creator>Colevas, A. Dimitrios</creator><creator>Fischbein, Nancy J.</creator><creator>Quon, Andrew</creator><creator>Le, Quynh‐Thu</creator><creator>Pinto, Harlan A.</creator><creator>Fee, Willard E.</creator><creator>Sunwoo, John B.</creator><creator>Sirjani, Davud</creator><creator>Hara, Wendy</creator><creator>Yao, Mike</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130401</creationdate><title>Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence</title><author>Ho, Allen S. ; Tsao, Gabriel J. ; Chen, Frank W. ; Shen, Tianjie ; Kaplan, Michael J. ; Colevas, A. Dimitrios ; Fischbein, Nancy J. ; Quon, Andrew ; Le, Quynh‐Thu ; Pinto, Harlan A. ; Fee, Willard E. ; Sunwoo, John B. ; Sirjani, Davud ; Hara, Wendy ; Yao, Mike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4252-d9898d3753bbecafce7659694eafa71ba807cf58f47f54837633142e0de980373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>computed tomography</topic><topic>Female</topic><topic>head and neck cancer</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Humans</topic><topic>integrated positron emission tomography and computed tomography</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multimodal Imaging</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Positron-Emission Tomography</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>salvage therapy</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>surveillance</topic><topic>Time Factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ho, Allen S.</creatorcontrib><creatorcontrib>Tsao, Gabriel J.</creatorcontrib><creatorcontrib>Chen, Frank W.</creatorcontrib><creatorcontrib>Shen, Tianjie</creatorcontrib><creatorcontrib>Kaplan, Michael J.</creatorcontrib><creatorcontrib>Colevas, A. Dimitrios</creatorcontrib><creatorcontrib>Fischbein, Nancy J.</creatorcontrib><creatorcontrib>Quon, Andrew</creatorcontrib><creatorcontrib>Le, Quynh‐Thu</creatorcontrib><creatorcontrib>Pinto, Harlan A.</creatorcontrib><creatorcontrib>Fee, Willard E.</creatorcontrib><creatorcontrib>Sunwoo, John B.</creatorcontrib><creatorcontrib>Sirjani, Davud</creatorcontrib><creatorcontrib>Hara, Wendy</creatorcontrib><creatorcontrib>Yao, Mike</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ho, Allen S.</au><au>Tsao, Gabriel J.</au><au>Chen, Frank W.</au><au>Shen, Tianjie</au><au>Kaplan, Michael J.</au><au>Colevas, A. Dimitrios</au><au>Fischbein, Nancy J.</au><au>Quon, Andrew</au><au>Le, Quynh‐Thu</au><au>Pinto, Harlan A.</au><au>Fee, Willard E.</au><au>Sunwoo, John B.</au><au>Sirjani, Davud</au><au>Hara, Wendy</au><au>Yao, Mike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>119</volume><issue>7</issue><spage>1349</spage><epage>1356</epage><pages>1349-1356</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND:
In head and neck cancer (HNC), 3‐month post‐treatment positron emission tomography (PET)/computed tomography (CT) reliably identifies persistent/recurrent disease. However, further PET/CT surveillance has unclear benefit. The impact of post‐treatment PET/CT surveillance on outcomes is assessed at 12 and 24 months.
METHODS:
A 10‐year retrospective analysis of HNC patients was carried out with long‐term serial imaging. Imaging at 3 months included either PET/CT or magnetic resonance imaging, with all subsequent imaging comprised of PET/CT. PET/CT scans at 12 and 24 months were evaluated only if preceding interval scans were negative. Of 1114 identified patients, 284 had 3‐month scans, 175 had 3‐ and 12‐month scans, and 77 had 3‐, 12‐, and 24‐month scans.
RESULTS:
PET/CT detection rates in clinically occult patients were 9% (15 of 175) at 12 months, and 4% (3 of 77) at 24 months. No difference in outcomes was identified between PET/CT‐detected and clinically detected recurrences, with similar 3‐year disease‐free survival (41% vs 46%, P = .91) and 3‐year overall survival (60% vs 54%, P = .70) rates. Compared with 3‐month PET/CT, 12‐month PET/CT demonstrated fewer equivocal reads (26% vs 10%, P < .001). Of scans deemed equivocal, 6% (5 of 89) were ultimately found to be positive.
CONCLUSIONS:
HNC patients with negative 3‐month imaging appear to derive limited benefit from subsequent PET/CT surveillance. No survival differences were observed between PET/CT‐detected and clinically detected recurrences, although larger prospective studies are needed for further investigation. Cancer 2013. © 2012 American Cancer Society.
Surveillance 12‐ and 24‐month post‐treatment positron emission tomography/computed tomography (PET/CT) scans are of limited yield in head and neck cancer patients with negative 3‐month imaging. No survival differences are observed between PET/CT‐detected and clinically detected recurrences.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23225544</pmid><doi>10.1002/cncr.27892</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - diagnosis computed tomography Female head and neck cancer Head and Neck Neoplasms - diagnosis Humans integrated positron emission tomography and computed tomography Magnetic Resonance Imaging Male Medical sciences Middle Aged Multimodal Imaging Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Positron-Emission Tomography Recurrence Retrospective Studies salvage therapy Squamous Cell Carcinoma of Head and Neck surveillance Time Factors Tomography, X-Ray Computed Tumors Young Adult |
| title | Impact of positron emission tomography/computed tomography surveillance at 12 and 24 months for detecting head and neck cancer recurrence |
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