Biogenic silver nanoparticles for cancer treatment: An experimental report
[Display omitted] ► Biogenic silver nanoparticles (AgNPs) using S. grandiflora. ► 22nm size of nanoparticles characterized using FESEM, EDAX, FTIR. ► In vitro evaluation of AgNPs against MCF-7. ► First report on biogenic AgNPs against human cancer cell line in fourth generation. A generation of nano...
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| Veröffentlicht in: | Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2013-06, Vol.106, p.86-92 |
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| creator | Jeyaraj, M. Sathishkumar, G. Sivanandhan, G. MubarakAli, D. Rajesh, M. Arun, R. Kapildev, G. Manickavasagam, M. Thajuddin, N. Premkumar, K. Ganapathi, A. |
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► Biogenic silver nanoparticles (AgNPs) using S. grandiflora. ► 22nm size of nanoparticles characterized using FESEM, EDAX, FTIR. ► In vitro evaluation of AgNPs against MCF-7. ► First report on biogenic AgNPs against human cancer cell line in fourth generation.
A generation of nanoparticles research has discussed recently. It is mandatory to elaborate the applications of biogenic nanoparticles in general and anticancereous property in particular. The present study was aimed to investigate the in vitro cytotoxicity effect of biogenic silver nanoparticles (AgNPs) against human breast cancer (MCF-7) cells towards the development of anticancer agent. Biogenic AgNPs were achieved by employing Sesbania grandiflora leaf extract as a novel reducing agent. It was well characterized by FESEM, EDAX and spectral studies showed spherical shaped nanoparticles in the size of 22nm in slightly agglomerated form. It was surprising that biogenic AgNPs showed cytotoxic effect against MCF-7 cell lines were confirmed by MTT, AO-EB, Hochest and COMET assays. There was an immediate induction of cellular damage in terms of loss of cell membrane integrity, oxidative stress and apoptosis were found in the cell which treated with AgNPs. This may be a first report on anti-MCF-7 property of biogenic AgNPs in the fourth generation of nanoparticles research. It is necessary to study the formulation and clinical trials to establish the nano drug to treat cancer cells. |
| doi_str_mv | 10.1016/j.colsurfb.2013.01.027 |
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► Biogenic silver nanoparticles (AgNPs) using S. grandiflora. ► 22nm size of nanoparticles characterized using FESEM, EDAX, FTIR. ► In vitro evaluation of AgNPs against MCF-7. ► First report on biogenic AgNPs against human cancer cell line in fourth generation.
A generation of nanoparticles research has discussed recently. It is mandatory to elaborate the applications of biogenic nanoparticles in general and anticancereous property in particular. The present study was aimed to investigate the in vitro cytotoxicity effect of biogenic silver nanoparticles (AgNPs) against human breast cancer (MCF-7) cells towards the development of anticancer agent. Biogenic AgNPs were achieved by employing Sesbania grandiflora leaf extract as a novel reducing agent. It was well characterized by FESEM, EDAX and spectral studies showed spherical shaped nanoparticles in the size of 22nm in slightly agglomerated form. It was surprising that biogenic AgNPs showed cytotoxic effect against MCF-7 cell lines were confirmed by MTT, AO-EB, Hochest and COMET assays. There was an immediate induction of cellular damage in terms of loss of cell membrane integrity, oxidative stress and apoptosis were found in the cell which treated with AgNPs. This may be a first report on anti-MCF-7 property of biogenic AgNPs in the fourth generation of nanoparticles research. It is necessary to study the formulation and clinical trials to establish the nano drug to treat cancer cells.</description><identifier>ISSN: 0927-7765</identifier><identifier>EISSN: 1873-4367</identifier><identifier>DOI: 10.1016/j.colsurfb.2013.01.027</identifier><identifier>PMID: 23434696</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Apoptosis ; Biosynthesis ; Breast Neoplasms - pathology ; Breast Neoplasms - therapy ; Cell Line, Tumor ; Comet Assay ; Female ; FESEM ; Humans ; MCF-7 ; Metal Nanoparticles ; Microscopy, Electron, Scanning ; Plant Extracts - pharmacology ; Sesbania - chemistry ; Sesbania grandiflora ; Silver - chemistry ; Silver nanoparticles ; Spectrophotometry, Ultraviolet</subject><ispartof>Colloids and surfaces, B, Biointerfaces, 2013-06, Vol.106, p.86-92</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-46b4d3b1a92e61a9387c03e2b6f66470707570b946bf4849ba34d35dd17a960e3</citedby><cites>FETCH-LOGICAL-c368t-46b4d3b1a92e61a9387c03e2b6f66470707570b946bf4849ba34d35dd17a960e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0927776513000490$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23434696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jeyaraj, M.</creatorcontrib><creatorcontrib>Sathishkumar, G.</creatorcontrib><creatorcontrib>Sivanandhan, G.</creatorcontrib><creatorcontrib>MubarakAli, D.</creatorcontrib><creatorcontrib>Rajesh, M.</creatorcontrib><creatorcontrib>Arun, R.</creatorcontrib><creatorcontrib>Kapildev, G.</creatorcontrib><creatorcontrib>Manickavasagam, M.</creatorcontrib><creatorcontrib>Thajuddin, N.</creatorcontrib><creatorcontrib>Premkumar, K.</creatorcontrib><creatorcontrib>Ganapathi, A.</creatorcontrib><title>Biogenic silver nanoparticles for cancer treatment: An experimental report</title><title>Colloids and surfaces, B, Biointerfaces</title><addtitle>Colloids Surf B Biointerfaces</addtitle><description>[Display omitted]
► Biogenic silver nanoparticles (AgNPs) using S. grandiflora. ► 22nm size of nanoparticles characterized using FESEM, EDAX, FTIR. ► In vitro evaluation of AgNPs against MCF-7. ► First report on biogenic AgNPs against human cancer cell line in fourth generation.
A generation of nanoparticles research has discussed recently. It is mandatory to elaborate the applications of biogenic nanoparticles in general and anticancereous property in particular. The present study was aimed to investigate the in vitro cytotoxicity effect of biogenic silver nanoparticles (AgNPs) against human breast cancer (MCF-7) cells towards the development of anticancer agent. Biogenic AgNPs were achieved by employing Sesbania grandiflora leaf extract as a novel reducing agent. It was well characterized by FESEM, EDAX and spectral studies showed spherical shaped nanoparticles in the size of 22nm in slightly agglomerated form. It was surprising that biogenic AgNPs showed cytotoxic effect against MCF-7 cell lines were confirmed by MTT, AO-EB, Hochest and COMET assays. There was an immediate induction of cellular damage in terms of loss of cell membrane integrity, oxidative stress and apoptosis were found in the cell which treated with AgNPs. This may be a first report on anti-MCF-7 property of biogenic AgNPs in the fourth generation of nanoparticles research. It is necessary to study the formulation and clinical trials to establish the nano drug to treat cancer cells.</description><subject>Apoptosis</subject><subject>Biosynthesis</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - therapy</subject><subject>Cell Line, Tumor</subject><subject>Comet Assay</subject><subject>Female</subject><subject>FESEM</subject><subject>Humans</subject><subject>MCF-7</subject><subject>Metal Nanoparticles</subject><subject>Microscopy, Electron, Scanning</subject><subject>Plant Extracts - pharmacology</subject><subject>Sesbania - chemistry</subject><subject>Sesbania grandiflora</subject><subject>Silver - chemistry</subject><subject>Silver nanoparticles</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0927-7765</issn><issn>1873-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkN9PwyAQgInRuDn9F5Y--tIKhUHrk3PxZ5b4os-E0qth6UoFuuh_L802Xw3JEXLf3XEfQnOCM4IJv9lk2rZ-cE2V5ZjQDJMM5-IETUkhaMooF6doistcpELwxQRdeL_BGOeMiHM0ySmjjJd8il7vjf2EzujEm3YHLulUZ3vlgtEt-KSxLtGq0zERHKiwhS7cJssuge8enBmfqk0c9NaFS3TWqNbD1eGeoY_Hh_fVc7p-e3pZLdepprwIKeMVq2lFVJkDj5EWQmMKecUbzpnA8SwErsrINaxgZaVo5Bd1TYQqOQY6Q9f7vr2zXwP4ILfGa2hb1YEdvCSUFHHzktCI8j2qnfXeQSP7-GnlfiTBcvQoN_LoUY4eJSYyeoyF88OModpC_Vd2FBeBuz0AcdOdASe9NhBF1caBDrK25r8Zv25Fh20</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Jeyaraj, M.</creator><creator>Sathishkumar, G.</creator><creator>Sivanandhan, G.</creator><creator>MubarakAli, D.</creator><creator>Rajesh, M.</creator><creator>Arun, R.</creator><creator>Kapildev, G.</creator><creator>Manickavasagam, M.</creator><creator>Thajuddin, N.</creator><creator>Premkumar, K.</creator><creator>Ganapathi, A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Biogenic silver nanoparticles for cancer treatment: An experimental report</title><author>Jeyaraj, M. ; Sathishkumar, G. ; Sivanandhan, G. ; MubarakAli, D. ; Rajesh, M. ; Arun, R. ; Kapildev, G. ; Manickavasagam, M. ; Thajuddin, N. ; Premkumar, K. ; Ganapathi, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-46b4d3b1a92e61a9387c03e2b6f66470707570b946bf4849ba34d35dd17a960e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Apoptosis</topic><topic>Biosynthesis</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - therapy</topic><topic>Cell Line, Tumor</topic><topic>Comet Assay</topic><topic>Female</topic><topic>FESEM</topic><topic>Humans</topic><topic>MCF-7</topic><topic>Metal Nanoparticles</topic><topic>Microscopy, Electron, Scanning</topic><topic>Plant Extracts - pharmacology</topic><topic>Sesbania - chemistry</topic><topic>Sesbania grandiflora</topic><topic>Silver - chemistry</topic><topic>Silver nanoparticles</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jeyaraj, M.</creatorcontrib><creatorcontrib>Sathishkumar, G.</creatorcontrib><creatorcontrib>Sivanandhan, G.</creatorcontrib><creatorcontrib>MubarakAli, D.</creatorcontrib><creatorcontrib>Rajesh, M.</creatorcontrib><creatorcontrib>Arun, R.</creatorcontrib><creatorcontrib>Kapildev, G.</creatorcontrib><creatorcontrib>Manickavasagam, M.</creatorcontrib><creatorcontrib>Thajuddin, N.</creatorcontrib><creatorcontrib>Premkumar, K.</creatorcontrib><creatorcontrib>Ganapathi, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jeyaraj, M.</au><au>Sathishkumar, G.</au><au>Sivanandhan, G.</au><au>MubarakAli, D.</au><au>Rajesh, M.</au><au>Arun, R.</au><au>Kapildev, G.</au><au>Manickavasagam, M.</au><au>Thajuddin, N.</au><au>Premkumar, K.</au><au>Ganapathi, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biogenic silver nanoparticles for cancer treatment: An experimental report</atitle><jtitle>Colloids and surfaces, B, Biointerfaces</jtitle><addtitle>Colloids Surf B Biointerfaces</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>106</volume><spage>86</spage><epage>92</epage><pages>86-92</pages><issn>0927-7765</issn><eissn>1873-4367</eissn><abstract>[Display omitted]
► Biogenic silver nanoparticles (AgNPs) using S. grandiflora. ► 22nm size of nanoparticles characterized using FESEM, EDAX, FTIR. ► In vitro evaluation of AgNPs against MCF-7. ► First report on biogenic AgNPs against human cancer cell line in fourth generation.
A generation of nanoparticles research has discussed recently. It is mandatory to elaborate the applications of biogenic nanoparticles in general and anticancereous property in particular. The present study was aimed to investigate the in vitro cytotoxicity effect of biogenic silver nanoparticles (AgNPs) against human breast cancer (MCF-7) cells towards the development of anticancer agent. Biogenic AgNPs were achieved by employing Sesbania grandiflora leaf extract as a novel reducing agent. It was well characterized by FESEM, EDAX and spectral studies showed spherical shaped nanoparticles in the size of 22nm in slightly agglomerated form. It was surprising that biogenic AgNPs showed cytotoxic effect against MCF-7 cell lines were confirmed by MTT, AO-EB, Hochest and COMET assays. There was an immediate induction of cellular damage in terms of loss of cell membrane integrity, oxidative stress and apoptosis were found in the cell which treated with AgNPs. This may be a first report on anti-MCF-7 property of biogenic AgNPs in the fourth generation of nanoparticles research. It is necessary to study the formulation and clinical trials to establish the nano drug to treat cancer cells.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23434696</pmid><doi>10.1016/j.colsurfb.2013.01.027</doi><tpages>7</tpages></addata></record> |
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| subjects | Apoptosis Biosynthesis Breast Neoplasms - pathology Breast Neoplasms - therapy Cell Line, Tumor Comet Assay Female FESEM Humans MCF-7 Metal Nanoparticles Microscopy, Electron, Scanning Plant Extracts - pharmacology Sesbania - chemistry Sesbania grandiflora Silver - chemistry Silver nanoparticles Spectrophotometry, Ultraviolet |
| title | Biogenic silver nanoparticles for cancer treatment: An experimental report |
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