Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells

Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can behave as an effective drug carrier. In this study, HA nanoparticles were prepared according to the hydrothermal method and used as a drug carrier for a water-insoluble anticancer drug, paclitaxel (Tax). The absorption of...

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Veröffentlicht in:	International journal of pharmaceutics 2013-03, Vol.446 (1-2), p.81-86
Hauptverfasser:	Watanabe, Kenji, Nishio, Yuki, Makiura, Rie, Nakahira, Atsushi, Kojima, Chie
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Cancer chemotherapy Cell Line, Tumor Cell Survival - drug effects Collagen Collagen - administration & dosage Collagen - chemistry drug carriers Drug Carriers - administration & dosage Drug Carriers - chemistry Durapatite - administration & dosage Durapatite - chemistry Gels Humans Hydrogel Hydroxyapatite metastasis nanoparticles Neoplasms - drug therapy Paclitaxel Paclitaxel - administration & dosage Paclitaxel - chemistry solvents
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