Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells
Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can behave as an effective drug carrier. In this study, HA nanoparticles were prepared according to the hydrothermal method and used as a drug carrier for a water-insoluble anticancer drug, paclitaxel (Tax). The absorption of...
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| Veröffentlicht in: | International journal of pharmaceutics 2013-03, Vol.446 (1-2), p.81-86 |
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| container_title | International journal of pharmaceutics |
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| creator | Watanabe, Kenji Nishio, Yuki Makiura, Rie Nakahira, Atsushi Kojima, Chie |
| description | Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can behave as an effective drug carrier. In this study, HA nanoparticles were prepared according to the hydrothermal method and used as a drug carrier for a water-insoluble anticancer drug, paclitaxel (Tax). The absorption of Tax onto the HA was dependent on the solvent composition. The Tax-loaded HA (Tax/HA) exhibited a lower level of activity than the free Tax because the HA material was not stably dispersed in aqueous media. The Tax/HA was therefore embedded in a collagen gel to give the Tax/HA-embedded collagen gel (Tax/HA/Col), which exhibited a higher level of activity than the Tax-containing collagen gel (Tax/Col). Interestingly, the highly metastatic MDA-MB-231 cells were more sensitive to the Tax/HA/Col than the poorly metastatic MCF-7 cells. Tax/HA/Col is therefore useful for the drug delivery into metastatic cancer cells. |
| doi_str_mv | 10.1016/j.ijpharm.2013.02.002 |
| format | Article |
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In this study, HA nanoparticles were prepared according to the hydrothermal method and used as a drug carrier for a water-insoluble anticancer drug, paclitaxel (Tax). The absorption of Tax onto the HA was dependent on the solvent composition. The Tax-loaded HA (Tax/HA) exhibited a lower level of activity than the free Tax because the HA material was not stably dispersed in aqueous media. The Tax/HA was therefore embedded in a collagen gel to give the Tax/HA-embedded collagen gel (Tax/HA/Col), which exhibited a higher level of activity than the Tax-containing collagen gel (Tax/Col). Interestingly, the highly metastatic MDA-MB-231 cells were more sensitive to the Tax/HA/Col than the poorly metastatic MCF-7 cells. Tax/HA/Col is therefore useful for the drug delivery into metastatic cancer cells.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2013.02.002</identifier><identifier>PMID: 23402979</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>absorption ; antineoplastic agents ; Antineoplastic Agents, Phytogenic - administration & dosage ; Antineoplastic Agents, Phytogenic - chemistry ; Cancer chemotherapy ; Cell Line, Tumor ; Cell Survival - drug effects ; Collagen ; Collagen - administration & dosage ; Collagen - chemistry ; drug carriers ; Drug Carriers - administration & dosage ; Drug Carriers - chemistry ; Durapatite - administration & dosage ; Durapatite - chemistry ; Gels ; Humans ; Hydrogel ; Hydroxyapatite ; metastasis ; nanoparticles ; Neoplasms - drug therapy ; Paclitaxel ; Paclitaxel - administration & dosage ; Paclitaxel - chemistry ; solvents</subject><ispartof>International journal of pharmaceutics, 2013-03, Vol.446 (1-2), p.81-86</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-9e568cf3ca8d3943af61dab1cf371932a43649712c77904b7fbffe9b3e19e533</citedby><cites>FETCH-LOGICAL-c389t-9e568cf3ca8d3943af61dab1cf371932a43649712c77904b7fbffe9b3e19e533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517313001361$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23402979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Watanabe, Kenji</creatorcontrib><creatorcontrib>Nishio, Yuki</creatorcontrib><creatorcontrib>Makiura, Rie</creatorcontrib><creatorcontrib>Nakahira, Atsushi</creatorcontrib><creatorcontrib>Kojima, Chie</creatorcontrib><title>Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can behave as an effective drug carrier. In this study, HA nanoparticles were prepared according to the hydrothermal method and used as a drug carrier for a water-insoluble anticancer drug, paclitaxel (Tax). The absorption of Tax onto the HA was dependent on the solvent composition. The Tax-loaded HA (Tax/HA) exhibited a lower level of activity than the free Tax because the HA material was not stably dispersed in aqueous media. The Tax/HA was therefore embedded in a collagen gel to give the Tax/HA-embedded collagen gel (Tax/HA/Col), which exhibited a higher level of activity than the Tax-containing collagen gel (Tax/Col). Interestingly, the highly metastatic MDA-MB-231 cells were more sensitive to the Tax/HA/Col than the poorly metastatic MCF-7 cells. Tax/HA/Col is therefore useful for the drug delivery into metastatic cancer cells.</description><subject>absorption</subject><subject>antineoplastic agents</subject><subject>Antineoplastic Agents, Phytogenic - administration & dosage</subject><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Cancer chemotherapy</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Collagen</subject><subject>Collagen - administration & dosage</subject><subject>Collagen - chemistry</subject><subject>drug carriers</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - chemistry</subject><subject>Durapatite - administration & dosage</subject><subject>Durapatite - chemistry</subject><subject>Gels</subject><subject>Humans</subject><subject>Hydrogel</subject><subject>Hydroxyapatite</subject><subject>metastasis</subject><subject>nanoparticles</subject><subject>Neoplasms - drug therapy</subject><subject>Paclitaxel</subject><subject>Paclitaxel - administration & dosage</subject><subject>Paclitaxel - chemistry</subject><subject>solvents</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EokvhJwA-cknqjySOTwhVhSJVAolytib2ZOvIWS92tmr-PV7twrWnkUbP-87oIeQ9ZzVnvLuaaj_tHyDNtWBc1kzUjIkXZMN7JSvZqO4l2TCp-qrlSl6QNzlPjLFOcPmaXAjZMKGV3pDpJ9jgF3jCUIUIDh19WF2KTyvsYfELXtkYAmxxV_ZD8o5uMWQKmbp02FKHwT9iWmle84JzpmNMdMYF8lLSllrYWUzUYgj5LXk1Qsj47jwvyf3Xm_vr2-rux7fv11_uKit7vVQa2663o7TQO6kbCWPHHQy8rBTXUkAju0YrLqxSmjWDGodxRD1I5CUq5SX5dKrdp_jngHkxs8_HB2CH8ZANl7xnWrS6LWh7Qm2KOScczT75GdJqODNHy2YyZ8vmaNkwYYrlkvtwPnEYZnT_U_-0FuDjCRghGtgmn83vX6WhZYwfIVWIzyei2MRHj8lk67HIcj6hXYyL_pkn_gJkXJwB</recordid><startdate>20130325</startdate><enddate>20130325</enddate><creator>Watanabe, Kenji</creator><creator>Nishio, Yuki</creator><creator>Makiura, Rie</creator><creator>Nakahira, Atsushi</creator><creator>Kojima, Chie</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130325</creationdate><title>Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells</title><author>Watanabe, Kenji ; Nishio, Yuki ; Makiura, Rie ; Nakahira, Atsushi ; Kojima, Chie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-9e568cf3ca8d3943af61dab1cf371932a43649712c77904b7fbffe9b3e19e533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>absorption</topic><topic>antineoplastic agents</topic><topic>Antineoplastic Agents, Phytogenic - administration & dosage</topic><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Cancer chemotherapy</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Collagen</topic><topic>Collagen - administration & dosage</topic><topic>Collagen - chemistry</topic><topic>drug carriers</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - chemistry</topic><topic>Durapatite - administration & dosage</topic><topic>Durapatite - chemistry</topic><topic>Gels</topic><topic>Humans</topic><topic>Hydrogel</topic><topic>Hydroxyapatite</topic><topic>metastasis</topic><topic>nanoparticles</topic><topic>Neoplasms - drug therapy</topic><topic>Paclitaxel</topic><topic>Paclitaxel - administration & dosage</topic><topic>Paclitaxel - chemistry</topic><topic>solvents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Watanabe, Kenji</creatorcontrib><creatorcontrib>Nishio, Yuki</creatorcontrib><creatorcontrib>Makiura, Rie</creatorcontrib><creatorcontrib>Nakahira, Atsushi</creatorcontrib><creatorcontrib>Kojima, Chie</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Watanabe, Kenji</au><au>Nishio, Yuki</au><au>Makiura, Rie</au><au>Nakahira, Atsushi</au><au>Kojima, Chie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2013-03-25</date><risdate>2013</risdate><volume>446</volume><issue>1-2</issue><spage>81</spage><epage>86</epage><pages>81-86</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>Hydroxyapatite (HA) is a biocompatible and porous inorganic material that can behave as an effective drug carrier. In this study, HA nanoparticles were prepared according to the hydrothermal method and used as a drug carrier for a water-insoluble anticancer drug, paclitaxel (Tax). The absorption of Tax onto the HA was dependent on the solvent composition. The Tax-loaded HA (Tax/HA) exhibited a lower level of activity than the free Tax because the HA material was not stably dispersed in aqueous media. The Tax/HA was therefore embedded in a collagen gel to give the Tax/HA-embedded collagen gel (Tax/HA/Col), which exhibited a higher level of activity than the Tax-containing collagen gel (Tax/Col). Interestingly, the highly metastatic MDA-MB-231 cells were more sensitive to the Tax/HA/Col than the poorly metastatic MCF-7 cells. Tax/HA/Col is therefore useful for the drug delivery into metastatic cancer cells.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23402979</pmid><doi>10.1016/j.ijpharm.2013.02.002</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | absorption antineoplastic agents Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Cancer chemotherapy Cell Line, Tumor Cell Survival - drug effects Collagen Collagen - administration & dosage Collagen - chemistry drug carriers Drug Carriers - administration & dosage Drug Carriers - chemistry Durapatite - administration & dosage Durapatite - chemistry Gels Humans Hydrogel Hydroxyapatite metastasis nanoparticles Neoplasms - drug therapy Paclitaxel Paclitaxel - administration & dosage Paclitaxel - chemistry solvents |
| title | Paclitaxel-loaded hydroxyapatite/collagen hybrid gels as drug delivery systems for metastatic cancer cells |
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