Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease
Purpose Serum levels of amylase and lipase are frequently increased in patients with chronic kidney disease (CKD). Relatively low serum pancreatic enzyme levels in CKD may represent a state of pancreatic insufficiency and may contribute to protein-energy wasting (PEW). We aimed to investigate the re...
Gespeichert in:
| Veröffentlicht in: | International urology and nephrology 2013-04, Vol.45 (2), p.477-484 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 484 |
|---|---|
| container_issue | 2 |
| container_start_page | 477 |
| container_title | International urology and nephrology |
| container_volume | 45 |
| creator | Ozkok, Abdullah Elcioglu, Omer Celal Cukadar, Tahsin Bakan, Ali Sasak, Gulsah Atilgan, Kadir Gokhan Alisir, Sabahat Kanbay, Mehmet Covic, Adrian Odabas, Ali Riza |
| description | Purpose
Serum levels of amylase and lipase are frequently increased in patients with chronic kidney disease (CKD). Relatively low serum pancreatic enzyme levels in CKD may represent a state of pancreatic insufficiency and may contribute to protein-energy wasting (PEW). We aimed to investigate the relationships of serum pancreatic enzyme levels with PEW, inflammation, and mortality in CKD patients.
Methods
Two hundred and thirty CKD patients (male/female: 144/86; mean age, 59 ± 16 years) were enrolled. Serum total α-amylase and lipase activities were measured by enzymatic colorimetric assays. Mean follow-up time was 18 ± 10 months. Forty-seven patients (20 %) died during this period.
Results
Serum amylase levels were increased in 95 patients (41 %) and serum lipase levels were increased in 71 patients (30 %) out of the 230 patients. Diabetic patients had significantly lower serum amylase levels than non-diabetic ones (86 ± 46 vs. 111 ± 60 IU/L,
p
|
| doi_str_mv | 10.1007/s11255-012-0237-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1317859693</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1317859693</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-1e22bcdf126ca4cb019f8da33f7fe1ab8a6ae1d7b563d07bc9e493f8a0c343b93</originalsourceid><addsrcrecordid>eNp9kTuOFDEQhi0EYoeFA5AghyQNfvQzRCte0kgkEFvVdjXjpdseXG5WTcQdOAa34iR4NAMhSVkl__9fVfoYeyrFCylE95KkVE1TCakqoXRXtffYTjadrlTT1_fZTmghK9kqfcUeEd0KIYZeiIfsSqlBdK0aduzXPt5xwrQu_AjBJoTsLcfwfVuQz_gNZ-LHhM7bzJeYMsw-bxyC45CQA1G0HjI6fufzgS8whzUnn30Mv3_89GGaYVng0kI-YIpk51P1xGkLLsUyx4cyPHsMmc459pBiKHt88S7gxp0nBMLH7MEEM-GTy3vNPr15_fHmXbX_8Pb9zat9ZXVd50qiUqN1k1SthdqOQg5T70DrqZtQwthDCyhdNzatdqIb7YD1oKceRPHrcdDX7Pk595ji1xUpm8WTxXmGgHElI7Xs-mZoB12k8iy15SRKOJlj8gukzUhhTozMmZEpjMyJkWmL59klfh0XdP8cf6EUgToLqHyFz5jMbVxTKCf_J_UPZgWlRw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1317859693</pqid></control><display><type>article</type><title>Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ozkok, Abdullah ; Elcioglu, Omer Celal ; Cukadar, Tahsin ; Bakan, Ali ; Sasak, Gulsah ; Atilgan, Kadir Gokhan ; Alisir, Sabahat ; Kanbay, Mehmet ; Covic, Adrian ; Odabas, Ali Riza</creator><creatorcontrib>Ozkok, Abdullah ; Elcioglu, Omer Celal ; Cukadar, Tahsin ; Bakan, Ali ; Sasak, Gulsah ; Atilgan, Kadir Gokhan ; Alisir, Sabahat ; Kanbay, Mehmet ; Covic, Adrian ; Odabas, Ali Riza</creatorcontrib><description><![CDATA[Purpose
Serum levels of amylase and lipase are frequently increased in patients with chronic kidney disease (CKD). Relatively low serum pancreatic enzyme levels in CKD may represent a state of pancreatic insufficiency and may contribute to protein-energy wasting (PEW). We aimed to investigate the relationships of serum pancreatic enzyme levels with PEW, inflammation, and mortality in CKD patients.
Methods
Two hundred and thirty CKD patients (male/female: 144/86; mean age, 59 ± 16 years) were enrolled. Serum total α-amylase and lipase activities were measured by enzymatic colorimetric assays. Mean follow-up time was 18 ± 10 months. Forty-seven patients (20 %) died during this period.
Results
Serum amylase levels were increased in 95 patients (41 %) and serum lipase levels were increased in 71 patients (30 %) out of the 230 patients. Diabetic patients had significantly lower serum amylase levels than non-diabetic ones (86 ± 46 vs. 111 ± 60 IU/L,
p
< 0.0001). Patients with ischemic heart disease also had significantly lower serum amylase (82 ± 37 vs. 108 ± 60 IU/L,
p
< 0.0001) and lipase levels (39 ± 36 vs. 57 ± 57 IU/L,
p
= 0.007). Serum amylase and lipase levels were directly correlated with serum creatinine (
r
= 0.173,
p
= 0.009 and
r
= 0.374,
p
< 0.0001) and albumin (
r
= 0.410,
p
< 0.0001 and 0.287,
p
< 0.0001), and inversely correlated with CRP (
r
= −0.223,
p
= 0.001 and
r
= −0.147,
p
= 0.027). The Kaplan–Meier analysis revealed survival advantages for both high-amylase and high-lipase groups in end-stage renal disease (ESRD) (CKD stage 5) patients (log rank,
p
< 0.001 and
p
= 0.02, respectively). In the Cox regression analysis, serum amylase was found to be an independent predictor for mortality.
Conclusion
Serum amylase activity was found to be an independent predictor of mortality in ESRD patients. Relatively low serum pancreatic enzyme levels in CKD may be regarded as a novel component of the malnutrition–inflammation–atherosclerosis syndrome.]]></description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-012-0237-6</identifier><identifier>PMID: 22907629</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>alpha-Amylases - blood ; Atherosclerosis - complications ; Cross-Sectional Studies ; Female ; Humans ; Inflammation - complications ; Lipase - blood ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Nephrology - Original Paper ; Predictive Value of Tests ; Prognosis ; Protein-Energy Malnutrition - complications ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - mortality ; Syndrome ; Urology</subject><ispartof>International urology and nephrology, 2013-04, Vol.45 (2), p.477-484</ispartof><rights>Springer Science+Business Media, B.V. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-1e22bcdf126ca4cb019f8da33f7fe1ab8a6ae1d7b563d07bc9e493f8a0c343b93</citedby><cites>FETCH-LOGICAL-c344t-1e22bcdf126ca4cb019f8da33f7fe1ab8a6ae1d7b563d07bc9e493f8a0c343b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-012-0237-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-012-0237-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22907629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozkok, Abdullah</creatorcontrib><creatorcontrib>Elcioglu, Omer Celal</creatorcontrib><creatorcontrib>Cukadar, Tahsin</creatorcontrib><creatorcontrib>Bakan, Ali</creatorcontrib><creatorcontrib>Sasak, Gulsah</creatorcontrib><creatorcontrib>Atilgan, Kadir Gokhan</creatorcontrib><creatorcontrib>Alisir, Sabahat</creatorcontrib><creatorcontrib>Kanbay, Mehmet</creatorcontrib><creatorcontrib>Covic, Adrian</creatorcontrib><creatorcontrib>Odabas, Ali Riza</creatorcontrib><title>Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description><![CDATA[Purpose
Serum levels of amylase and lipase are frequently increased in patients with chronic kidney disease (CKD). Relatively low serum pancreatic enzyme levels in CKD may represent a state of pancreatic insufficiency and may contribute to protein-energy wasting (PEW). We aimed to investigate the relationships of serum pancreatic enzyme levels with PEW, inflammation, and mortality in CKD patients.
Methods
Two hundred and thirty CKD patients (male/female: 144/86; mean age, 59 ± 16 years) were enrolled. Serum total α-amylase and lipase activities were measured by enzymatic colorimetric assays. Mean follow-up time was 18 ± 10 months. Forty-seven patients (20 %) died during this period.
Results
Serum amylase levels were increased in 95 patients (41 %) and serum lipase levels were increased in 71 patients (30 %) out of the 230 patients. Diabetic patients had significantly lower serum amylase levels than non-diabetic ones (86 ± 46 vs. 111 ± 60 IU/L,
p
< 0.0001). Patients with ischemic heart disease also had significantly lower serum amylase (82 ± 37 vs. 108 ± 60 IU/L,
p
< 0.0001) and lipase levels (39 ± 36 vs. 57 ± 57 IU/L,
p
= 0.007). Serum amylase and lipase levels were directly correlated with serum creatinine (
r
= 0.173,
p
= 0.009 and
r
= 0.374,
p
< 0.0001) and albumin (
r
= 0.410,
p
< 0.0001 and 0.287,
p
< 0.0001), and inversely correlated with CRP (
r
= −0.223,
p
= 0.001 and
r
= −0.147,
p
= 0.027). The Kaplan–Meier analysis revealed survival advantages for both high-amylase and high-lipase groups in end-stage renal disease (ESRD) (CKD stage 5) patients (log rank,
p
< 0.001 and
p
= 0.02, respectively). In the Cox regression analysis, serum amylase was found to be an independent predictor for mortality.
Conclusion
Serum amylase activity was found to be an independent predictor of mortality in ESRD patients. Relatively low serum pancreatic enzyme levels in CKD may be regarded as a novel component of the malnutrition–inflammation–atherosclerosis syndrome.]]></description><subject>alpha-Amylases - blood</subject><subject>Atherosclerosis - complications</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - complications</subject><subject>Lipase - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nephrology - Original Paper</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Protein-Energy Malnutrition - complications</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - mortality</subject><subject>Syndrome</subject><subject>Urology</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kTuOFDEQhi0EYoeFA5AghyQNfvQzRCte0kgkEFvVdjXjpdseXG5WTcQdOAa34iR4NAMhSVkl__9fVfoYeyrFCylE95KkVE1TCakqoXRXtffYTjadrlTT1_fZTmghK9kqfcUeEd0KIYZeiIfsSqlBdK0aduzXPt5xwrQu_AjBJoTsLcfwfVuQz_gNZ-LHhM7bzJeYMsw-bxyC45CQA1G0HjI6fufzgS8whzUnn30Mv3_89GGaYVng0kI-YIpk51P1xGkLLsUyx4cyPHsMmc459pBiKHt88S7gxp0nBMLH7MEEM-GTy3vNPr15_fHmXbX_8Pb9zat9ZXVd50qiUqN1k1SthdqOQg5T70DrqZtQwthDCyhdNzatdqIb7YD1oKceRPHrcdDX7Pk595ji1xUpm8WTxXmGgHElI7Xs-mZoB12k8iy15SRKOJlj8gukzUhhTozMmZEpjMyJkWmL59klfh0XdP8cf6EUgToLqHyFz5jMbVxTKCf_J_UPZgWlRw</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Ozkok, Abdullah</creator><creator>Elcioglu, Omer Celal</creator><creator>Cukadar, Tahsin</creator><creator>Bakan, Ali</creator><creator>Sasak, Gulsah</creator><creator>Atilgan, Kadir Gokhan</creator><creator>Alisir, Sabahat</creator><creator>Kanbay, Mehmet</creator><creator>Covic, Adrian</creator><creator>Odabas, Ali Riza</creator><general>Springer Netherlands</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130401</creationdate><title>Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease</title><author>Ozkok, Abdullah ; Elcioglu, Omer Celal ; Cukadar, Tahsin ; Bakan, Ali ; Sasak, Gulsah ; Atilgan, Kadir Gokhan ; Alisir, Sabahat ; Kanbay, Mehmet ; Covic, Adrian ; Odabas, Ali Riza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-1e22bcdf126ca4cb019f8da33f7fe1ab8a6ae1d7b563d07bc9e493f8a0c343b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>alpha-Amylases - blood</topic><topic>Atherosclerosis - complications</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation - complications</topic><topic>Lipase - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nephrology - Original Paper</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Protein-Energy Malnutrition - complications</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - mortality</topic><topic>Syndrome</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozkok, Abdullah</creatorcontrib><creatorcontrib>Elcioglu, Omer Celal</creatorcontrib><creatorcontrib>Cukadar, Tahsin</creatorcontrib><creatorcontrib>Bakan, Ali</creatorcontrib><creatorcontrib>Sasak, Gulsah</creatorcontrib><creatorcontrib>Atilgan, Kadir Gokhan</creatorcontrib><creatorcontrib>Alisir, Sabahat</creatorcontrib><creatorcontrib>Kanbay, Mehmet</creatorcontrib><creatorcontrib>Covic, Adrian</creatorcontrib><creatorcontrib>Odabas, Ali Riza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozkok, Abdullah</au><au>Elcioglu, Omer Celal</au><au>Cukadar, Tahsin</au><au>Bakan, Ali</au><au>Sasak, Gulsah</au><au>Atilgan, Kadir Gokhan</au><au>Alisir, Sabahat</au><au>Kanbay, Mehmet</au><au>Covic, Adrian</au><au>Odabas, Ali Riza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>45</volume><issue>2</issue><spage>477</spage><epage>484</epage><pages>477-484</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><abstract><![CDATA[Purpose
Serum levels of amylase and lipase are frequently increased in patients with chronic kidney disease (CKD). Relatively low serum pancreatic enzyme levels in CKD may represent a state of pancreatic insufficiency and may contribute to protein-energy wasting (PEW). We aimed to investigate the relationships of serum pancreatic enzyme levels with PEW, inflammation, and mortality in CKD patients.
Methods
Two hundred and thirty CKD patients (male/female: 144/86; mean age, 59 ± 16 years) were enrolled. Serum total α-amylase and lipase activities were measured by enzymatic colorimetric assays. Mean follow-up time was 18 ± 10 months. Forty-seven patients (20 %) died during this period.
Results
Serum amylase levels were increased in 95 patients (41 %) and serum lipase levels were increased in 71 patients (30 %) out of the 230 patients. Diabetic patients had significantly lower serum amylase levels than non-diabetic ones (86 ± 46 vs. 111 ± 60 IU/L,
p
< 0.0001). Patients with ischemic heart disease also had significantly lower serum amylase (82 ± 37 vs. 108 ± 60 IU/L,
p
< 0.0001) and lipase levels (39 ± 36 vs. 57 ± 57 IU/L,
p
= 0.007). Serum amylase and lipase levels were directly correlated with serum creatinine (
r
= 0.173,
p
= 0.009 and
r
= 0.374,
p
< 0.0001) and albumin (
r
= 0.410,
p
< 0.0001 and 0.287,
p
< 0.0001), and inversely correlated with CRP (
r
= −0.223,
p
= 0.001 and
r
= −0.147,
p
= 0.027). The Kaplan–Meier analysis revealed survival advantages for both high-amylase and high-lipase groups in end-stage renal disease (ESRD) (CKD stage 5) patients (log rank,
p
< 0.001 and
p
= 0.02, respectively). In the Cox regression analysis, serum amylase was found to be an independent predictor for mortality.
Conclusion
Serum amylase activity was found to be an independent predictor of mortality in ESRD patients. Relatively low serum pancreatic enzyme levels in CKD may be regarded as a novel component of the malnutrition–inflammation–atherosclerosis syndrome.]]></abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>22907629</pmid><doi>10.1007/s11255-012-0237-6</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-1623 |
| ispartof | International urology and nephrology, 2013-04, Vol.45 (2), p.477-484 |
| issn | 0301-1623 1573-2584 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1317859693 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | alpha-Amylases - blood Atherosclerosis - complications Cross-Sectional Studies Female Humans Inflammation - complications Lipase - blood Male Medicine Medicine & Public Health Middle Aged Nephrology Nephrology - Original Paper Predictive Value of Tests Prognosis Protein-Energy Malnutrition - complications Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - mortality Syndrome Urology |
| title | Low serum pancreatic enzyme levels predict mortality and are associated with malnutrition–inflammation–atherosclerosis syndrome in patients with chronic kidney disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T09%3A18%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Low%20serum%20pancreatic%20enzyme%20levels%20predict%20mortality%20and%20are%20associated%20with%20malnutrition%E2%80%93inflammation%E2%80%93atherosclerosis%20syndrome%20in%20patients%20with%20chronic%20kidney%20disease&rft.jtitle=International%20urology%20and%20nephrology&rft.au=Ozkok,%20Abdullah&rft.date=2013-04-01&rft.volume=45&rft.issue=2&rft.spage=477&rft.epage=484&rft.pages=477-484&rft.issn=0301-1623&rft.eissn=1573-2584&rft_id=info:doi/10.1007/s11255-012-0237-6&rft_dat=%3Cproquest_cross%3E1317859693%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1317859693&rft_id=info:pmid/22907629&rfr_iscdi=true |