Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case
This report describes a rare case of hepatocellular carcinoma (HCC) producing granulocyte colony-stimulating factor (G-CSF). A 46-year-old male with chronic hepatitis B, who presented with fever, general malaise, loss of appetite, and weight loss, had a huge liver mass in the portal region. He had m...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2013-04, Vol.43 (4), p.439-445 |
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| creator | Kohno, Mikihiro Shirabe, Ken Mano, Yohei Muto, Jun Motomura, Takashi Takeishi, Kazuki Toshima, Takeo Yoshimatsu, Masanori Ijichi, Hideki Harada, Noboru Aishima, Shinichi Uchiyama, Hideaki Yoshizumi, Tomoharu Taketomi, Akinobu Maehara, Yoshihiko |
| description | This report describes a rare case of hepatocellular carcinoma (HCC) producing granulocyte colony-stimulating factor (G-CSF). A 46-year-old male with chronic hepatitis B, who presented with fever, general malaise, loss of appetite, and weight loss, had a huge liver mass in the portal region. He had marked granulocytosis and his serum level of G-CSF was elevated. Complete tumor resection was performed, and the pathological assessment of the resected specimen revealed HCC with extensive sarcomatous changes and immunohistochemical staining for G-CSF and G-CSF receptor. Only a few cases of G-CSF-producing HCC have been reported, and this is the first case of G-CSF-producing HCC that also expressed G-CSF receptor. |
| doi_str_mv | 10.1007/s00595-012-0202-0 |
| format | Article |
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A 46-year-old male with chronic hepatitis B, who presented with fever, general malaise, loss of appetite, and weight loss, had a huge liver mass in the portal region. He had marked granulocytosis and his serum level of G-CSF was elevated. Complete tumor resection was performed, and the pathological assessment of the resected specimen revealed HCC with extensive sarcomatous changes and immunohistochemical staining for G-CSF and G-CSF receptor. Only a few cases of G-CSF-producing HCC have been reported, and this is the first case of G-CSF-producing HCC that also expressed G-CSF receptor.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-012-0202-0</identifier><identifier>PMID: 22638568</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Biomarkers, Tumor - metabolism ; Carcinoma, Hepatocellular - metabolism ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Case Report ; Fatal Outcome ; Granulocyte Colony-Stimulating Factor - metabolism ; Hepatectomy ; Humans ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Receptors, Granulocyte Colony-Stimulating Factor - metabolism ; Surgery ; Surgical Oncology</subject><ispartof>Surgery today (Tokyo, Japan), 2013-04, Vol.43 (4), p.439-445</ispartof><rights>Springer 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-54cbcdc327b137b44fdebbcffe6ef2a99d9f79862dad76bee94291f294462c393</citedby><cites>FETCH-LOGICAL-c397t-54cbcdc327b137b44fdebbcffe6ef2a99d9f79862dad76bee94291f294462c393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-012-0202-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-012-0202-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22638568$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kohno, Mikihiro</creatorcontrib><creatorcontrib>Shirabe, Ken</creatorcontrib><creatorcontrib>Mano, Yohei</creatorcontrib><creatorcontrib>Muto, Jun</creatorcontrib><creatorcontrib>Motomura, Takashi</creatorcontrib><creatorcontrib>Takeishi, Kazuki</creatorcontrib><creatorcontrib>Toshima, Takeo</creatorcontrib><creatorcontrib>Yoshimatsu, Masanori</creatorcontrib><creatorcontrib>Ijichi, Hideki</creatorcontrib><creatorcontrib>Harada, Noboru</creatorcontrib><creatorcontrib>Aishima, Shinichi</creatorcontrib><creatorcontrib>Uchiyama, Hideaki</creatorcontrib><creatorcontrib>Yoshizumi, Tomoharu</creatorcontrib><creatorcontrib>Taketomi, Akinobu</creatorcontrib><creatorcontrib>Maehara, Yoshihiko</creatorcontrib><title>Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>This report describes a rare case of hepatocellular carcinoma (HCC) producing granulocyte colony-stimulating factor (G-CSF). 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Only a few cases of G-CSF-producing HCC have been reported, and this is the first case of G-CSF-producing HCC that also expressed G-CSF receptor.</description><subject>Biomarkers, Tumor - metabolism</subject><subject>Carcinoma, Hepatocellular - metabolism</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Case Report</subject><subject>Fatal Outcome</subject><subject>Granulocyte Colony-Stimulating Factor - metabolism</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Receptors, Granulocyte Colony-Stimulating Factor - metabolism</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElPHDEQhS0UBMPyA7hEPuZi8NaLc4tQWCQkLnC23O4y06i7PbHdCXPgv6dGQ3LkYktV7z3V-wi5EPxScN5cZc4rUzEuJOOS43NAVkKrmslWqC9kxY0WTEgjjslJzq-cS91yfkSOpaxVW9XtirzfJjcvY_TbAtTHMc5blsswLaMrw_zCgvMlJrZJsV88DugaNq5ED-OIkkS9SziOk6N_hrKm8FZgzsNvoBkXOC5xydSv3fwC-TtNsImp0BioQ2eGM3IY3Jjh_OM_Jc83P5-u79jD4-399Y8H5pVpCqu073zvlWw6oZpO69BD1_kQoIYgnTG9CY1pa9m7vqk7AKOxdJBG61pihDol3_a52OPXArnYaci7Dm4GPNAKJZq2arXiKBV7qU8x5wTBbtIwubS1gtsddbunbpG63VG3O8_Xj_ilm6D_7_iHGQVyL8i4QhTJvsYlzVj5k9S_B8WRQg</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Kohno, Mikihiro</creator><creator>Shirabe, Ken</creator><creator>Mano, Yohei</creator><creator>Muto, Jun</creator><creator>Motomura, Takashi</creator><creator>Takeishi, Kazuki</creator><creator>Toshima, Takeo</creator><creator>Yoshimatsu, Masanori</creator><creator>Ijichi, Hideki</creator><creator>Harada, Noboru</creator><creator>Aishima, Shinichi</creator><creator>Uchiyama, Hideaki</creator><creator>Yoshizumi, Tomoharu</creator><creator>Taketomi, Akinobu</creator><creator>Maehara, Yoshihiko</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130401</creationdate><title>Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case</title><author>Kohno, Mikihiro ; 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| ispartof | Surgery today (Tokyo, Japan), 2013-04, Vol.43 (4), p.439-445 |
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| subjects | Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Case Report Fatal Outcome Granulocyte Colony-Stimulating Factor - metabolism Hepatectomy Humans Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - surgery Male Medicine Medicine & Public Health Middle Aged Receptors, Granulocyte Colony-Stimulating Factor - metabolism Surgery Surgical Oncology |
| title | Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: report of a case |
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