Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy
Purpose Sivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome. This study retrospectively investigated the effect of sivelestat on respiratory function in patients who underwent esophagectomy. M...
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| Veröffentlicht in: | Surgery today (Tokyo, Japan) Japan), 2013-04, Vol.43 (4), p.361-366 |
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| container_title | Surgery today (Tokyo, Japan) |
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| creator | Nagai, Yohei Watanabe, Masayuki Baba, Yoshihumi Iwatsuki, Masaaki Hirashima, Kotaro Karashima, Ryuichi Kurashige, Jyunji Kinoshita, Koichi Baba, Hideo |
| description | Purpose
Sivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome. This study retrospectively investigated the effect of sivelestat on respiratory function in patients who underwent esophagectomy.
Methods
Patients who underwent esophagectomy for thoracic esophageal cancer between 2005 and 2010 were included in this study. Forty-two were treated perioperatively with sivelestat (4.8 mg/kg/day; sivelestat group) and the remaining 35 were not (control group). Sivelestat was administered continuously from the beginning of surgery until postoperative day 3. All patients were administered methylprednisolone for 3 days. The perioperative clinical and laboratory data, total sequential organ failure assessment score, PaO
2
/FiO
2
ratio (P/F ratio) and postoperative complications were compared between the two groups.
Results
There were no significant differences between the groups in the patients’ background data. The P/F ratio immediately after surgery was significantly higher in the sivelestat group than in the control group (
p
|
| doi_str_mv | 10.1007/s00595-013-0508-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1317858371</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1317858371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c463t-52918871fbc380c76c2d8421cb2017280eff2712f9f64b8cb4ac7c7df48d7ada3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EouXxAWxQlmwCM7YTu0tU8ZKQYAFry3HGkKqNg51W6t9jKLBkZY985ur6MHaGcIkA6ioBVLOqBBQlVKDLeo9NUYq65BrFPpvCTGKJfIYTdpTSAoBLDXDIJlxI5BXKKXPPkTbUj92GCvKe3FgEX6Q8LimNNk99MYQ0hoGi_aYipaHL9xC3RdulEFuKqbB-pFiM7yFa17mCUhje7VuOC6vtCTvwdpno9Oc8Zq-3Ny_z-_Lx6e5hfv1YOlmLsaxyUa0V-sYJDU7VjrdacnQNB1RcQ-7HFXI_87VstGukdcqp1kvdKttaccwudrlDDB_rXN-suuRoubQ9hXUyKFDpSguFGcUd6mJIKZI3Q-xWNm4Ngvlya3ZuTXZrvtyaOu-c_8SvmxW1fxu_MjPAd0DKT_0bRbMI69jnL_-T-glaMIbT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1317858371</pqid></control><display><type>article</type><title>Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Nagai, Yohei ; Watanabe, Masayuki ; Baba, Yoshihumi ; Iwatsuki, Masaaki ; Hirashima, Kotaro ; Karashima, Ryuichi ; Kurashige, Jyunji ; Kinoshita, Koichi ; Baba, Hideo</creator><creatorcontrib>Nagai, Yohei ; Watanabe, Masayuki ; Baba, Yoshihumi ; Iwatsuki, Masaaki ; Hirashima, Kotaro ; Karashima, Ryuichi ; Kurashige, Jyunji ; Kinoshita, Koichi ; Baba, Hideo</creatorcontrib><description>Purpose
Sivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome. This study retrospectively investigated the effect of sivelestat on respiratory function in patients who underwent esophagectomy.
Methods
Patients who underwent esophagectomy for thoracic esophageal cancer between 2005 and 2010 were included in this study. Forty-two were treated perioperatively with sivelestat (4.8 mg/kg/day; sivelestat group) and the remaining 35 were not (control group). Sivelestat was administered continuously from the beginning of surgery until postoperative day 3. All patients were administered methylprednisolone for 3 days. The perioperative clinical and laboratory data, total sequential organ failure assessment score, PaO
2
/FiO
2
ratio (P/F ratio) and postoperative complications were compared between the two groups.
Results
There were no significant differences between the groups in the patients’ background data. The P/F ratio immediately after surgery was significantly higher in the sivelestat group than in the control group (
p
< 0.05). The respiratory rate immediately after surgery and the temperature on postoperative day 2 were significantly lower in the sivelestat group than in the control group (
p
< 0.05). There were no differences in any of the other clinical data or complications.
Conclusions
Perioperative administration of sivelestat improves postoperative respiratory function in patients after esophagectomy.</description><identifier>ISSN: 0941-1291</identifier><identifier>EISSN: 1436-2813</identifier><identifier>DOI: 10.1007/s00595-013-0508-6</identifier><identifier>PMID: 23412514</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject><![CDATA[Acute Lung Injury - diagnosis ; Acute Lung Injury - etiology ; Acute Lung Injury - prevention & control ; Adult ; Aged ; Aged, 80 and over ; Anti-Inflammatory Agents - therapeutic use ; Drug Administration Schedule ; Drug Therapy, Combination ; Esophageal Neoplasms - surgery ; Esophagectomy ; Female ; Glycine - analogs & derivatives ; Glycine - therapeutic use ; Humans ; Intraoperative Care ; Male ; Medicine ; Medicine & Public Health ; Methylprednisolone - therapeutic use ; Middle Aged ; Original Article ; Postoperative Care ; Postoperative Complications - diagnosis ; Postoperative Complications - prevention & control ; Respiratory Distress Syndrome, Adult - diagnosis ; Respiratory Distress Syndrome, Adult - etiology ; Respiratory Distress Syndrome, Adult - prevention & control ; Respiratory Function Tests ; Retrospective Studies ; Serine Proteinase Inhibitors - therapeutic use ; Sulfonamides - therapeutic use ; Surgery ; Surgical Oncology ; Systemic Inflammatory Response Syndrome - diagnosis ; Systemic Inflammatory Response Syndrome - etiology ; Systemic Inflammatory Response Syndrome - prevention & control ; Treatment Outcome]]></subject><ispartof>Surgery today (Tokyo, Japan), 2013-04, Vol.43 (4), p.361-366</ispartof><rights>Springer Japan 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-52918871fbc380c76c2d8421cb2017280eff2712f9f64b8cb4ac7c7df48d7ada3</citedby><cites>FETCH-LOGICAL-c463t-52918871fbc380c76c2d8421cb2017280eff2712f9f64b8cb4ac7c7df48d7ada3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00595-013-0508-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00595-013-0508-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23412514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagai, Yohei</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><creatorcontrib>Baba, Yoshihumi</creatorcontrib><creatorcontrib>Iwatsuki, Masaaki</creatorcontrib><creatorcontrib>Hirashima, Kotaro</creatorcontrib><creatorcontrib>Karashima, Ryuichi</creatorcontrib><creatorcontrib>Kurashige, Jyunji</creatorcontrib><creatorcontrib>Kinoshita, Koichi</creatorcontrib><creatorcontrib>Baba, Hideo</creatorcontrib><title>Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy</title><title>Surgery today (Tokyo, Japan)</title><addtitle>Surg Today</addtitle><addtitle>Surg Today</addtitle><description>Purpose
Sivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome. This study retrospectively investigated the effect of sivelestat on respiratory function in patients who underwent esophagectomy.
Methods
Patients who underwent esophagectomy for thoracic esophageal cancer between 2005 and 2010 were included in this study. Forty-two were treated perioperatively with sivelestat (4.8 mg/kg/day; sivelestat group) and the remaining 35 were not (control group). Sivelestat was administered continuously from the beginning of surgery until postoperative day 3. All patients were administered methylprednisolone for 3 days. The perioperative clinical and laboratory data, total sequential organ failure assessment score, PaO
2
/FiO
2
ratio (P/F ratio) and postoperative complications were compared between the two groups.
Results
There were no significant differences between the groups in the patients’ background data. The P/F ratio immediately after surgery was significantly higher in the sivelestat group than in the control group (
p
< 0.05). The respiratory rate immediately after surgery and the temperature on postoperative day 2 were significantly lower in the sivelestat group than in the control group (
p
< 0.05). There were no differences in any of the other clinical data or complications.
Conclusions
Perioperative administration of sivelestat improves postoperative respiratory function in patients after esophagectomy.</description><subject>Acute Lung Injury - diagnosis</subject><subject>Acute Lung Injury - etiology</subject><subject>Acute Lung Injury - prevention & control</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Drug Administration Schedule</subject><subject>Drug Therapy, Combination</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Esophagectomy</subject><subject>Female</subject><subject>Glycine - analogs & derivatives</subject><subject>Glycine - therapeutic use</subject><subject>Humans</subject><subject>Intraoperative Care</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Postoperative Care</subject><subject>Postoperative Complications - diagnosis</subject><subject>Postoperative Complications - prevention & control</subject><subject>Respiratory Distress Syndrome, Adult - diagnosis</subject><subject>Respiratory Distress Syndrome, Adult - etiology</subject><subject>Respiratory Distress Syndrome, Adult - prevention & control</subject><subject>Respiratory Function Tests</subject><subject>Retrospective Studies</subject><subject>Serine Proteinase Inhibitors - therapeutic use</subject><subject>Sulfonamides - therapeutic use</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Systemic Inflammatory Response Syndrome - diagnosis</subject><subject>Systemic Inflammatory Response Syndrome - etiology</subject><subject>Systemic Inflammatory Response Syndrome - prevention & control</subject><subject>Treatment Outcome</subject><issn>0941-1291</issn><issn>1436-2813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EouXxAWxQlmwCM7YTu0tU8ZKQYAFry3HGkKqNg51W6t9jKLBkZY985ur6MHaGcIkA6ioBVLOqBBQlVKDLeo9NUYq65BrFPpvCTGKJfIYTdpTSAoBLDXDIJlxI5BXKKXPPkTbUj92GCvKe3FgEX6Q8LimNNk99MYQ0hoGi_aYipaHL9xC3RdulEFuKqbB-pFiM7yFa17mCUhje7VuOC6vtCTvwdpno9Oc8Zq-3Ny_z-_Lx6e5hfv1YOlmLsaxyUa0V-sYJDU7VjrdacnQNB1RcQ-7HFXI_87VstGukdcqp1kvdKttaccwudrlDDB_rXN-suuRoubQ9hXUyKFDpSguFGcUd6mJIKZI3Q-xWNm4Ngvlya3ZuTXZrvtyaOu-c_8SvmxW1fxu_MjPAd0DKT_0bRbMI69jnL_-T-glaMIbT</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Nagai, Yohei</creator><creator>Watanabe, Masayuki</creator><creator>Baba, Yoshihumi</creator><creator>Iwatsuki, Masaaki</creator><creator>Hirashima, Kotaro</creator><creator>Karashima, Ryuichi</creator><creator>Kurashige, Jyunji</creator><creator>Kinoshita, Koichi</creator><creator>Baba, Hideo</creator><general>Springer Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130401</creationdate><title>Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy</title><author>Nagai, Yohei ; Watanabe, Masayuki ; Baba, Yoshihumi ; Iwatsuki, Masaaki ; Hirashima, Kotaro ; Karashima, Ryuichi ; Kurashige, Jyunji ; Kinoshita, Koichi ; Baba, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-52918871fbc380c76c2d8421cb2017280eff2712f9f64b8cb4ac7c7df48d7ada3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Lung Injury - diagnosis</topic><topic>Acute Lung Injury - etiology</topic><topic>Acute Lung Injury - prevention & control</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Drug Administration Schedule</topic><topic>Drug Therapy, Combination</topic><topic>Esophageal Neoplasms - surgery</topic><topic>Esophagectomy</topic><topic>Female</topic><topic>Glycine - analogs & derivatives</topic><topic>Glycine - therapeutic use</topic><topic>Humans</topic><topic>Intraoperative Care</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Postoperative Care</topic><topic>Postoperative Complications - diagnosis</topic><topic>Postoperative Complications - prevention & control</topic><topic>Respiratory Distress Syndrome, Adult - diagnosis</topic><topic>Respiratory Distress Syndrome, Adult - etiology</topic><topic>Respiratory Distress Syndrome, Adult - prevention & control</topic><topic>Respiratory Function Tests</topic><topic>Retrospective Studies</topic><topic>Serine Proteinase Inhibitors - therapeutic use</topic><topic>Sulfonamides - therapeutic use</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Systemic Inflammatory Response Syndrome - diagnosis</topic><topic>Systemic Inflammatory Response Syndrome - etiology</topic><topic>Systemic Inflammatory Response Syndrome - prevention & control</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagai, Yohei</creatorcontrib><creatorcontrib>Watanabe, Masayuki</creatorcontrib><creatorcontrib>Baba, Yoshihumi</creatorcontrib><creatorcontrib>Iwatsuki, Masaaki</creatorcontrib><creatorcontrib>Hirashima, Kotaro</creatorcontrib><creatorcontrib>Karashima, Ryuichi</creatorcontrib><creatorcontrib>Kurashige, Jyunji</creatorcontrib><creatorcontrib>Kinoshita, Koichi</creatorcontrib><creatorcontrib>Baba, Hideo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery today (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagai, Yohei</au><au>Watanabe, Masayuki</au><au>Baba, Yoshihumi</au><au>Iwatsuki, Masaaki</au><au>Hirashima, Kotaro</au><au>Karashima, Ryuichi</au><au>Kurashige, Jyunji</au><au>Kinoshita, Koichi</au><au>Baba, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy</atitle><jtitle>Surgery today (Tokyo, Japan)</jtitle><stitle>Surg Today</stitle><addtitle>Surg Today</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>43</volume><issue>4</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>0941-1291</issn><eissn>1436-2813</eissn><abstract>Purpose
Sivelestat, a selective inhibitor of neutrophil elastase, has been reported to reduce acute lung injury associated with systemic inflammatory response syndrome. This study retrospectively investigated the effect of sivelestat on respiratory function in patients who underwent esophagectomy.
Methods
Patients who underwent esophagectomy for thoracic esophageal cancer between 2005 and 2010 were included in this study. Forty-two were treated perioperatively with sivelestat (4.8 mg/kg/day; sivelestat group) and the remaining 35 were not (control group). Sivelestat was administered continuously from the beginning of surgery until postoperative day 3. All patients were administered methylprednisolone for 3 days. The perioperative clinical and laboratory data, total sequential organ failure assessment score, PaO
2
/FiO
2
ratio (P/F ratio) and postoperative complications were compared between the two groups.
Results
There were no significant differences between the groups in the patients’ background data. The P/F ratio immediately after surgery was significantly higher in the sivelestat group than in the control group (
p
< 0.05). The respiratory rate immediately after surgery and the temperature on postoperative day 2 were significantly lower in the sivelestat group than in the control group (
p
< 0.05). There were no differences in any of the other clinical data or complications.
Conclusions
Perioperative administration of sivelestat improves postoperative respiratory function in patients after esophagectomy.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>23412514</pmid><doi>10.1007/s00595-013-0508-6</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0941-1291 |
| ispartof | Surgery today (Tokyo, Japan), 2013-04, Vol.43 (4), p.361-366 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Acute Lung Injury - diagnosis Acute Lung Injury - etiology Acute Lung Injury - prevention & control Adult Aged Aged, 80 and over Anti-Inflammatory Agents - therapeutic use Drug Administration Schedule Drug Therapy, Combination Esophageal Neoplasms - surgery Esophagectomy Female Glycine - analogs & derivatives Glycine - therapeutic use Humans Intraoperative Care Male Medicine Medicine & Public Health Methylprednisolone - therapeutic use Middle Aged Original Article Postoperative Care Postoperative Complications - diagnosis Postoperative Complications - prevention & control Respiratory Distress Syndrome, Adult - diagnosis Respiratory Distress Syndrome, Adult - etiology Respiratory Distress Syndrome, Adult - prevention & control Respiratory Function Tests Retrospective Studies Serine Proteinase Inhibitors - therapeutic use Sulfonamides - therapeutic use Surgery Surgical Oncology Systemic Inflammatory Response Syndrome - diagnosis Systemic Inflammatory Response Syndrome - etiology Systemic Inflammatory Response Syndrome - prevention & control Treatment Outcome |
| title | Preventive effect of sivelestat on postoperative respiratory disorders after thoracic esophagectomy |
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