Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice
To examine the spatiotemporal profiles and localization of CysLT1R, CysLT2R and GPR17 in mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD). PD model was induced by subcutaneous injection of MPTP (25 mg/kg) for 5 d in adult male C57BL/6 mice. At d10 after...
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| Veröffentlicht in: | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban 2013-01, Vol.42 (1), p.52-60 |
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| container_title | Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban |
| container_volume | 42 |
| creator | Wang, Hao Shi, Qiaojuan Shi, Wenzhen Zhang, Xiayan Wang, Xiaorong Zhang, Lihui Fang, Sanhua Lu, Yunbi Zhang, Weiping Wei, Erqing |
| description | To examine the spatiotemporal profiles and localization of CysLT1R, CysLT2R and GPR17 in mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD).
PD model was induced by subcutaneous injection of MPTP (25 mg/kg) for 5 d in adult male C57BL/6 mice. At d10 after MPTP injection, the expression and cellular localization of CysLT1R, CysLT2R and GPR17 in the substantia nigra were detected by immunohistochemistry and immunofluorescence.
CysLT1R, CysLT22 and GPR17 were normally localized in TH-positive dopaminergic neurons and microglia, while CysLT2R was also expressed in astrocytes. In dopaminergic neurons, approximately 91% co-expressed GPR17, 77% co-expressed CysLT1R and 52% co-expressed CysLT2R. Compared with the control group, TH-positive cells in the substantia nigra were significantly reduced in PD mice. CysLT1R, CysLT2R and GPR17-positive cells were significantly reduced; and CysLT1R, CysLT2R, GPR17-positive dopaminergic neurons were also significantly reduced in the P |
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PD model was induced by subcutaneous injection of MPTP (25 mg/kg) for 5 d in adult male C57BL/6 mice. At d10 after MPTP injection, the expression and cellular localization of CysLT1R, CysLT2R and GPR17 in the substantia nigra were detected by immunohistochemistry and immunofluorescence.
CysLT1R, CysLT22 and GPR17 were normally localized in TH-positive dopaminergic neurons and microglia, while CysLT2R was also expressed in astrocytes. In dopaminergic neurons, approximately 91% co-expressed GPR17, 77% co-expressed CysLT1R and 52% co-expressed CysLT2R. Compared with the control group, TH-positive cells in the substantia nigra were significantly reduced in PD mice. CysLT1R, CysLT2R and GPR17-positive cells were significantly reduced; and CysLT1R, CysLT2R, GPR17-positive dopaminergic neurons were also significantly reduced in the P</description><identifier>ISSN: 1008-9292</identifier><identifier>PMID: 23505108</identifier><language>chi</language><publisher>China</publisher><subject>Animals ; Brain - metabolism ; Disease Models, Animal ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Tissue Proteins - metabolism ; Parkinson Disease - metabolism ; Receptors, G-Protein-Coupled - metabolism ; Receptors, Leukotriene - metabolism</subject><ispartof>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban, 2013-01, Vol.42 (1), p.52-60</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23505108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Hao</creatorcontrib><creatorcontrib>Shi, Qiaojuan</creatorcontrib><creatorcontrib>Shi, Wenzhen</creatorcontrib><creatorcontrib>Zhang, Xiayan</creatorcontrib><creatorcontrib>Wang, Xiaorong</creatorcontrib><creatorcontrib>Zhang, Lihui</creatorcontrib><creatorcontrib>Fang, Sanhua</creatorcontrib><creatorcontrib>Lu, Yunbi</creatorcontrib><creatorcontrib>Zhang, Weiping</creatorcontrib><creatorcontrib>Wei, Erqing</creatorcontrib><title>Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice</title><title>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</title><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><description>To examine the spatiotemporal profiles and localization of CysLT1R, CysLT2R and GPR17 in mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD).
PD model was induced by subcutaneous injection of MPTP (25 mg/kg) for 5 d in adult male C57BL/6 mice. At d10 after MPTP injection, the expression and cellular localization of CysLT1R, CysLT2R and GPR17 in the substantia nigra were detected by immunohistochemistry and immunofluorescence.
CysLT1R, CysLT22 and GPR17 were normally localized in TH-positive dopaminergic neurons and microglia, while CysLT2R was also expressed in astrocytes. In dopaminergic neurons, approximately 91% co-expressed GPR17, 77% co-expressed CysLT1R and 52% co-expressed CysLT2R. Compared with the control group, TH-positive cells in the substantia nigra were significantly reduced in PD mice. CysLT1R, CysLT2R and GPR17-positive cells were significantly reduced; and CysLT1R, CysLT2R, GPR17-positive dopaminergic neurons were also significantly reduced in the P</description><subject>Animals</subject><subject>Brain - metabolism</subject><subject>Disease Models, Animal</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Parkinson Disease - metabolism</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Receptors, Leukotriene - metabolism</subject><issn>1008-9292</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UEtLw0AQ3oNiS-1fkD16MJDdbfZxlFKrULCUeg77mMDSJBt3EzB_wN9tjJU5zHzzPQbmBi1JnstMUUUXaJ2SN3lBmJgqv0MLyooJ5nKJvndfXYSJDy3WrcPOpz56M_S_i1BhO6YefDvWuIbhEiYOWsARLHR9iAlvx3Q4k9PsnWd6eprB_ngiAvsWm6j9HHXU8eLbNOVOR0AnwE1wUOPGW7hHt5WuE6yvfYU-Xnbn7Wt2eN-_bZ8PWUco7zPlpNRy46wTYInbcE6pYZYS55QsuKSVyjnXGyutFYYpVglHKi4EOJIzZdgKPf7ldjF8DpD6svHJQl3rFsKQSsKIkIWkQk7Sh6t0MA24sou-0XEs_3_HfgCzgWuF</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Wang, Hao</creator><creator>Shi, Qiaojuan</creator><creator>Shi, Wenzhen</creator><creator>Zhang, Xiayan</creator><creator>Wang, Xiaorong</creator><creator>Zhang, Lihui</creator><creator>Fang, Sanhua</creator><creator>Lu, Yunbi</creator><creator>Zhang, Weiping</creator><creator>Wei, Erqing</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201301</creationdate><title>Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice</title><author>Wang, Hao ; Shi, Qiaojuan ; Shi, Wenzhen ; Zhang, Xiayan ; Wang, Xiaorong ; Zhang, Lihui ; Fang, Sanhua ; Lu, Yunbi ; Zhang, Weiping ; Wei, Erqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-9d88a84dcd7ec1d46622b3c21dd985682f9066a4c8cc7b393f7d1f677ed1039b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Brain - metabolism</topic><topic>Disease Models, Animal</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Parkinson Disease - metabolism</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Receptors, Leukotriene - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Wang, Hao</creatorcontrib><creatorcontrib>Shi, Qiaojuan</creatorcontrib><creatorcontrib>Shi, Wenzhen</creatorcontrib><creatorcontrib>Zhang, Xiayan</creatorcontrib><creatorcontrib>Wang, Xiaorong</creatorcontrib><creatorcontrib>Zhang, Lihui</creatorcontrib><creatorcontrib>Fang, Sanhua</creatorcontrib><creatorcontrib>Lu, Yunbi</creatorcontrib><creatorcontrib>Zhang, Weiping</creatorcontrib><creatorcontrib>Wei, Erqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Hao</au><au>Shi, Qiaojuan</au><au>Shi, Wenzhen</au><au>Zhang, Xiayan</au><au>Wang, Xiaorong</au><au>Zhang, Lihui</au><au>Fang, Sanhua</au><au>Lu, Yunbi</au><au>Zhang, Weiping</au><au>Wei, Erqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice</atitle><jtitle>Zhejiang da xue xue bao. Journal of Zhejiang University. Medical sciences. Yi xue ban</jtitle><addtitle>Zhejiang Da Xue Xue Bao Yi Xue Ban</addtitle><date>2013-01</date><risdate>2013</risdate><volume>42</volume><issue>1</issue><spage>52</spage><epage>60</epage><pages>52-60</pages><issn>1008-9292</issn><abstract>To examine the spatiotemporal profiles and localization of CysLT1R, CysLT2R and GPR17 in mice with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced Parkinson disease (PD).
PD model was induced by subcutaneous injection of MPTP (25 mg/kg) for 5 d in adult male C57BL/6 mice. At d10 after MPTP injection, the expression and cellular localization of CysLT1R, CysLT2R and GPR17 in the substantia nigra were detected by immunohistochemistry and immunofluorescence.
CysLT1R, CysLT22 and GPR17 were normally localized in TH-positive dopaminergic neurons and microglia, while CysLT2R was also expressed in astrocytes. In dopaminergic neurons, approximately 91% co-expressed GPR17, 77% co-expressed CysLT1R and 52% co-expressed CysLT2R. Compared with the control group, TH-positive cells in the substantia nigra were significantly reduced in PD mice. CysLT1R, CysLT2R and GPR17-positive cells were significantly reduced; and CysLT1R, CysLT2R, GPR17-positive dopaminergic neurons were also significantly reduced in the P</abstract><cop>China</cop><pmid>23505108</pmid><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Brain - metabolism Disease Models, Animal Male Mice Mice, Inbred C57BL Nerve Tissue Proteins - metabolism Parkinson Disease - metabolism Receptors, G-Protein-Coupled - metabolism Receptors, Leukotriene - metabolism |
| title | Expression and distribution of cysteinyl leukotriene receptors CysLT1R and CysLT2R, and GPR17 in brain of Parkinson disease model mice |
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