Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer
Background and Objectives Inflammation has been implicated in the initiation and progression of thyroid cancer. Neutrophil‐to‐lymphocyte ratio (NLR) is a simple index of systemic inflammatory response, and has been shown to be a prognostic indicator in some types of cancer. The aim of this study was...
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| Veröffentlicht in: | Journal of surgical oncology 2013-04, Vol.107 (5), p.493-497 |
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| container_title | Journal of surgical oncology |
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| creator | Liu, Chien-Liang Lee, Jie-Jen Liu, Tsang-Pai Chang, Yuan-Ching Hsu, Yi-Chiung Cheng, Shih-Ping |
| description | Background and Objectives
Inflammation has been implicated in the initiation and progression of thyroid cancer. Neutrophil‐to‐lymphocyte ratio (NLR) is a simple index of systemic inflammatory response, and has been shown to be a prognostic indicator in some types of cancer. The aim of this study was to examine the relationship between NLR and clinicopathological features in patients with differentiated thyroid cancer.
Methods
Total white blood cell and differential counts of 159 patients with differentiated thyroid cancer were compared to those of 318 age‐ and sex‐matched controls undergoing thyroidectomy for benign thyroid nodules. Clinicopathological variables, stratified by NLR tertiles, were analyzed.
Results
There was no difference in NLR between patients having benign and malignant thyroid nodules (P = 0.293). Cancer patients in the higher NLR tertile had significantly larger tumor size (P = 0.004). Higher NLR was observed in patients with high American Thyroid Association (ATA) risk of recurrence.
Conclusions
High preoperative NLR was associated with increased tumor size and high ATA risk of recurrence in patients with differentiated thyroid cancer. J. Surg. Oncol. 2013;107:493–497. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jso.23270 |
| format | Article |
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Inflammation has been implicated in the initiation and progression of thyroid cancer. Neutrophil‐to‐lymphocyte ratio (NLR) is a simple index of systemic inflammatory response, and has been shown to be a prognostic indicator in some types of cancer. The aim of this study was to examine the relationship between NLR and clinicopathological features in patients with differentiated thyroid cancer.
Methods
Total white blood cell and differential counts of 159 patients with differentiated thyroid cancer were compared to those of 318 age‐ and sex‐matched controls undergoing thyroidectomy for benign thyroid nodules. Clinicopathological variables, stratified by NLR tertiles, were analyzed.
Results
There was no difference in NLR between patients having benign and malignant thyroid nodules (P = 0.293). Cancer patients in the higher NLR tertile had significantly larger tumor size (P = 0.004). Higher NLR was observed in patients with high American Thyroid Association (ATA) risk of recurrence.
Conclusions
High preoperative NLR was associated with increased tumor size and high ATA risk of recurrence in patients with differentiated thyroid cancer. J. Surg. Oncol. 2013;107:493–497. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.23270</identifier><identifier>PMID: 22996403</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adenocarcinoma, Follicular - pathology ; Adenocarcinoma, Follicular - surgery ; Adenocarcinoma, Papillary - pathology ; Adenocarcinoma, Papillary - surgery ; Adult ; Case-Control Studies ; Cell Count ; Female ; Humans ; inflammation ; Lymphocytes - metabolism ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local ; neutrophil-to-lymphocyte ratio ; Neutrophils - metabolism ; Risk Assessment ; thyroid cancer ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy</subject><ispartof>Journal of surgical oncology, 2013-04, Vol.107 (5), p.493-497</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3910-a424f24d7b86e6ecf2c59ad27d8be160f418ff1c28cac50a8b368128b5619ed73</citedby><cites>FETCH-LOGICAL-c3910-a424f24d7b86e6ecf2c59ad27d8be160f418ff1c28cac50a8b368128b5619ed73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.23270$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.23270$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22996403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Chien-Liang</creatorcontrib><creatorcontrib>Lee, Jie-Jen</creatorcontrib><creatorcontrib>Liu, Tsang-Pai</creatorcontrib><creatorcontrib>Chang, Yuan-Ching</creatorcontrib><creatorcontrib>Hsu, Yi-Chiung</creatorcontrib><creatorcontrib>Cheng, Shih-Ping</creatorcontrib><title>Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background and Objectives
Inflammation has been implicated in the initiation and progression of thyroid cancer. Neutrophil‐to‐lymphocyte ratio (NLR) is a simple index of systemic inflammatory response, and has been shown to be a prognostic indicator in some types of cancer. The aim of this study was to examine the relationship between NLR and clinicopathological features in patients with differentiated thyroid cancer.
Methods
Total white blood cell and differential counts of 159 patients with differentiated thyroid cancer were compared to those of 318 age‐ and sex‐matched controls undergoing thyroidectomy for benign thyroid nodules. Clinicopathological variables, stratified by NLR tertiles, were analyzed.
Results
There was no difference in NLR between patients having benign and malignant thyroid nodules (P = 0.293). Cancer patients in the higher NLR tertile had significantly larger tumor size (P = 0.004). Higher NLR was observed in patients with high American Thyroid Association (ATA) risk of recurrence.
Conclusions
High preoperative NLR was associated with increased tumor size and high ATA risk of recurrence in patients with differentiated thyroid cancer. J. Surg. Oncol. 2013;107:493–497. © 2012 Wiley Periodicals, Inc.</description><subject>Adenocarcinoma, Follicular - pathology</subject><subject>Adenocarcinoma, Follicular - surgery</subject><subject>Adenocarcinoma, Papillary - pathology</subject><subject>Adenocarcinoma, Papillary - surgery</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Cell Count</subject><subject>Female</subject><subject>Humans</subject><subject>inflammation</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Recurrence, Local</subject><subject>neutrophil-to-lymphocyte ratio</subject><subject>Neutrophils - metabolism</subject><subject>Risk Assessment</subject><subject>thyroid cancer</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10Utv1DAQB3ALgehSOPAFkCUucEjrR-LER7pAeWwp4iGOlmNPtF6SONiOSvj0uN1tD0icbGt-89fIg9BTSk4oIex0F_0J46wm99CKEikKSWRzH61yjRVlLckRehTjjhAipSgfoiPGri-Er9B41ntv8QhzCn7aur5IvuiXYdp6syTAQSfnsfEhQK8TRHzl0hanefABR_cHsBvxlA2M6VCzrusg5LfL3uK0XYJ3Fhs9GgiP0YNO9xGeHM5j9P3tm2_rd8Xm8vz9-tWmMFxSUuiSlR0rbd02AgSYjplKastq27RABelK2nQdNawx2lRENy0XDWVNWwkqwdb8GL3Y507B_5ohJjW4aKDv9Qh-jopyWjeVkKTK9Pk_dOfnMObpbhSXrBQ8q5d7ZYKPMUCnpuAGHRZFibpegspLUDdLyPbZIXFuB7B38vbXMzjdgyvXw_L_JPXh6-VtZLHvcDHB77sOHX4qUfO6Uj8-navXF9X68-bio_rC_wJT4KHj</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Liu, Chien-Liang</creator><creator>Lee, Jie-Jen</creator><creator>Liu, Tsang-Pai</creator><creator>Chang, Yuan-Ching</creator><creator>Hsu, Yi-Chiung</creator><creator>Cheng, Shih-Ping</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20130401</creationdate><title>Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer</title><author>Liu, Chien-Liang ; Lee, Jie-Jen ; Liu, Tsang-Pai ; Chang, Yuan-Ching ; Hsu, Yi-Chiung ; Cheng, Shih-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3910-a424f24d7b86e6ecf2c59ad27d8be160f418ff1c28cac50a8b368128b5619ed73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenocarcinoma, Follicular - pathology</topic><topic>Adenocarcinoma, Follicular - surgery</topic><topic>Adenocarcinoma, Papillary - pathology</topic><topic>Adenocarcinoma, Papillary - surgery</topic><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Cell Count</topic><topic>Female</topic><topic>Humans</topic><topic>inflammation</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Recurrence, Local</topic><topic>neutrophil-to-lymphocyte ratio</topic><topic>Neutrophils - metabolism</topic><topic>Risk Assessment</topic><topic>thyroid cancer</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Chien-Liang</creatorcontrib><creatorcontrib>Lee, Jie-Jen</creatorcontrib><creatorcontrib>Liu, Tsang-Pai</creatorcontrib><creatorcontrib>Chang, Yuan-Ching</creatorcontrib><creatorcontrib>Hsu, Yi-Chiung</creatorcontrib><creatorcontrib>Cheng, Shih-Ping</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Chien-Liang</au><au>Lee, Jie-Jen</au><au>Liu, Tsang-Pai</au><au>Chang, Yuan-Ching</au><au>Hsu, Yi-Chiung</au><au>Cheng, Shih-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>107</volume><issue>5</issue><spage>493</spage><epage>497</epage><pages>493-497</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
Inflammation has been implicated in the initiation and progression of thyroid cancer. Neutrophil‐to‐lymphocyte ratio (NLR) is a simple index of systemic inflammatory response, and has been shown to be a prognostic indicator in some types of cancer. The aim of this study was to examine the relationship between NLR and clinicopathological features in patients with differentiated thyroid cancer.
Methods
Total white blood cell and differential counts of 159 patients with differentiated thyroid cancer were compared to those of 318 age‐ and sex‐matched controls undergoing thyroidectomy for benign thyroid nodules. Clinicopathological variables, stratified by NLR tertiles, were analyzed.
Results
There was no difference in NLR between patients having benign and malignant thyroid nodules (P = 0.293). Cancer patients in the higher NLR tertile had significantly larger tumor size (P = 0.004). Higher NLR was observed in patients with high American Thyroid Association (ATA) risk of recurrence.
Conclusions
High preoperative NLR was associated with increased tumor size and high ATA risk of recurrence in patients with differentiated thyroid cancer. J. Surg. Oncol. 2013;107:493–497. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22996403</pmid><doi>10.1002/jso.23270</doi><tpages>5</tpages></addata></record> |
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| subjects | Adenocarcinoma, Follicular - pathology Adenocarcinoma, Follicular - surgery Adenocarcinoma, Papillary - pathology Adenocarcinoma, Papillary - surgery Adult Case-Control Studies Cell Count Female Humans inflammation Lymphocytes - metabolism Male Middle Aged Multivariate Analysis Neoplasm Recurrence, Local neutrophil-to-lymphocyte ratio Neutrophils - metabolism Risk Assessment thyroid cancer Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy |
| title | Blood neutrophil-to-lymphocyte ratio correlates with tumor size in patients with differentiated thyroid cancer |
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