Synergistic Effect of Surface Modification With Poly(ethylene glycol) and Immunosuppressants on Repetitive Pancreatic Islet Transplantation Into Antecedently Sensitized Rat

Abstract Background Polymeric modification of islet surface is highly effective in preventing transplanted islets against host immune reactions. However, grafted islets are eventually rejected by the host immune reaction. Thus, repetitive islet transplantation is needed to treat type 1 diabetic pati...

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Veröffentlicht in:	Transplantation proceedings 2013-03, Vol.45 (2), p.585-590
Hauptverfasser:	Jeong, J.-H, Yook, S, Hwang, J.W, Jung, M.J, Moon, H.T, Lee, D.Y, Byun, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Biomarkers - metabolism Blood Glucose - metabolism Coculture Techniques Cyclosporine - pharmacology Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - surgery Drug Synergism Drug Therapy, Combination Immunohistochemistry Immunosuppressive Agents - pharmacology Islets of Langerhans - drug effects Islets of Langerhans - immunology Islets of Langerhans - metabolism Islets of Langerhans Transplantation - immunology L-Lactate Dehydrogenase - metabolism Male Polyethylene Glycols - pharmacology Rats Rats, Inbred F344 Rats, Sprague-Dawley Spleen - cytology Spleen - immunology Surgery Time Factors Tissue Culture Techniques
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