Impact of host ageing on the metastatic phenotype

► Lung metastases grow less aggressively and reach smaller sizes in lungs of old mice. ► Selection for lung metastasis in old and young mice increases tumor aggressiveness. ► Metastatic cells isolated from young and old mice differ in their properties. ► Electric impedance distinguishes metastatic c...

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Veröffentlicht in:	Mechanisms of ageing and development 2013-03, Vol.134 (3-4), p.118-129
Hauptverfasser:	Meehan, Brian, Dombrovsky, Alexander, Lau, Karrie, Lai, Tiffany, Magnus, Nathalie, Montermini, Laura, Rak, Janusz
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing Aging Animals Carcinoma, Lewis Lung Cell Adhesion Cell Cycle Cell Shape Cellular impedance Disease Progression Female Flow Cytometry Gene Expression Profiling Gene Expression Regulation Mice Mice, Inbred C57BL Neoplasm Metastasis Neoplasms - pathology Phenotype Phosphorylation Time Factors Tumor dissemination Tumor heterogeneity
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