Mini-review: Foldosome regulation of androgen receptor action in prostate cancer

► The simplistic view that chaperones act only in the cytoplasm has recently been overturned. ► The nuclear role of chaperones and foldosome proteins is summarised. ► Dysregulation of foldosome components has been reported in many cancers. ► We focus on the foldosome in prostate cancer, highlighting...

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Veröffentlicht in:	Molecular and cellular endocrinology 2013-04, Vol.369 (1-2), p.52-62
Hauptverfasser:	Querol Cano, Laia, Lavery, Derek N., Bevan, Charlotte L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen receptor Binding Sites Cancer therapeutics Cell Nucleus - metabolism Chaperone Foldosome Gene Expression Regulation, Neoplastic Heat shock protein Heat-Shock Proteins - metabolism Heat-Shock Proteins - physiology HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - physiology Humans Intramolecular Oxidoreductases - antagonists & inhibitors Intramolecular Oxidoreductases - metabolism Intramolecular Oxidoreductases - physiology Male Models, Biological Molecular Chaperones - physiology Prostaglandin-E Synthases Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - therapy Receptors, Androgen - chemistry Receptors, Androgen - metabolism Signal Transduction Triterpenes - pharmacology
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