The absence of macrophage Nrf2 promotes early atherogenesis

The loss of nuclear factor E2-related factor 2 (Nrf2) has been shown to protect against atherogenesis in apoE-deficient mice. The mechanism by which Nrf2 deficiency affords atheroprotection in this model is currently unknown, but combined systemic and local vascular effects on lesion macrophages hav...

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Veröffentlicht in:	Cardiovascular research 2013-04, Vol.98 (1), p.107-115
Hauptverfasser:	Ruotsalainen, Anna-Kaisa, Inkala, Matias, Partanen, Mervi E, Lappalainen, Jari P, Kansanen, Emilia, Mäkinen, Petri I, Heinonen, Suvi E, Laitinen, Heidi M, Heikkilä, Janne, Vatanen, Tero, Hörkkö, Sohvi, Yamamoto, Masayuki, Ylä-Herttuala, Seppo, Jauhiainen, Matti, Levonen, Anna-Liisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - etiology Chemokine CCL2 - genetics Cholesterol - metabolism Female Macrophages - physiology Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - physiology Receptors, LDL - physiology Receptors, Scavenger - analysis
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