Polymyositis with cytochrome C oxidase negative fibers—a pathological and clinical challenge

Abstract Polymyositis (PM) with cytochrome C oxidase negative fibers also referred to as PM with mitochondrial pathology (PM-Mito) is characterized by the symptoms of inclusion body myositis (IBM) and by the myopathological findings of PM except for an increase of muscle fibers with insufficient mit...

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Veröffentlicht in:	Annals of diagnostic pathology 2013-04, Vol.17 (2), p.183-186
Hauptverfasser:	Siepmann, Timo, MD, Tesch, Manfred, MD, Krause, Florian, BA, Illigens, Ben Min-Woo, MD, Stoltenburg-Didinger, Gisela, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged COX-negative fibers Cytochrome C oxidase Electron Transport Complex IV - metabolism Female Humans Immunohistochemistry Inclusion body myositis Male Microscopy, Electron, Transmission Mitochondria - ultrastructure Muscle Fibers, Skeletal - enzymology Muscle Fibers, Skeletal - ultrastructure Pathology Polymyositis Polymyositis - classification Polymyositis - enzymology Polymyositis - pathology Poor responsiveness to glucocorticoids
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