Nicotine Treatment Improves Toll-Like Receptor 2 and Toll-Like Receptor 9 Responsiveness in Active Pulmonary Sarcoidosis

Background New evidence links nicotine to the regulation of T cell-mediated inflammation via α7 nicotinic cholinergic receptor activation, and chronic nicotine exposure (smoking) reduces the incidence of granulomatous diseases. We sought to determine whether nicotine treatment was well tolerated whi...

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Veröffentlicht in:	Chest 2013-02, Vol.143 (2), p.461-470
Hauptverfasser:	Julian, Mark W., MS, Shao, Guohong, MD, Schlesinger, Larry S., MD, Huang, Qin, MD, Cosmar, David G., BA, Bhatt, Nitin Y., MD, Culver, Daniel A., MD, FCCP, Baughman, Robert P., MD, FCCP, Wood, Karen L., MD, FCCP, Crouser, Elliott D., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Surface - metabolism Female Forkhead Transcription Factors - metabolism Humans Immunity, Cellular - drug effects Male Middle Aged Nicotine - pharmacology Nicotine - therapeutic use Nicotinic Agonists - pharmacology Nicotinic Agonists - therapeutic use Phenotype Pulmonary/Respiratory Sarcoidosis, Pulmonary - drug therapy Sarcoidosis, Pulmonary - metabolism Sarcoidosis, Pulmonary - pathology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Toll-Like Receptor 2 - immunology Toll-Like Receptor 2 - metabolism Toll-Like Receptor 9 - immunology Toll-Like Receptor 9 - metabolism Treatment Outcome
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