Affinity Profiling of the Cellular Kinome for the Nucleotide Cofactors ATP, ADP, and GTP

Most kinase inhibitor drugs target the binding site of the nucleotide cosubstrate ATP. The high intracellular concentration of ATP can strongly affect inhibitor potency and selectivity depending on the affinity of the target kinase for ATP. Here we used a defined chemoproteomics system based on comp...

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Veröffentlicht in:	ACS chemical biology 2013-03, Vol.8 (3), p.599-607
Hauptverfasser:	Becher, Isabelle, Savitski, Mikhail M, Savitski, Maria Fälth, Hopf, Carsten, Bantscheff, Marcus, Drewes, Gerard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Binding, Competitive Cell Line, Tumor Guanosine Triphosphate - metabolism Humans Jurkat Cells Models, Molecular Phosphotransferases - metabolism
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