Stereoselective synthesis of a new class of potent and selective inhibitors of human Δ8,7-sterol isomerase

Secosteroid-type cis-configured amino alcohols are potent and selective inhibitors of human Δ8,7-sterol isomerase in cholesterol biosynthesis, whereas epimeric trans-aminoalcohols and aminoketones are inactive. Starting from Grundmann′s ketone a new chemotype of inhibitors of the post-squalene part...

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