The Chromatin Remodeling Gene ARID1A Is a New Prognostic Marker in Clear Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (ccRCC) is the most common tumor of the adult kidney, with an increasing rate of incidence. Recently, exome sequencing studies have revealed that the SWI/SNF (switch/sucrose nonfermentable) members PBRM1 and ARID1A are mutated in ccRCC, and it has also been suggested...

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Veröffentlicht in:	The American journal of pathology 2013-04, Vol.182 (4), p.1163-1170
Hauptverfasser:	Lichner, Zsuzsanna, Scorilas, Andreas, White, Nicole M.A, Girgis, Andrew H, Rotstein, Lora, Wiegand, Kimberly C, Latif, Ashraf, Chow, Christina, Huntsman, David, Yousef, George M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers, Tumor - genetics Carcinoma, Renal Cell - classification Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Chromatin Assembly and Disassembly - genetics Disease-Free Survival DNA Copy Number Variations - genetics Down-Regulation - genetics Female Gene Expression Regulation, Neoplastic Genes, Neoplasm - genetics Humans Kidney - metabolism Kidney - pathology Kidney Neoplasms - classification Kidney Neoplasms - genetics Kidney Neoplasms - pathology Male Nuclear Proteins - genetics Pathology Prognosis RNA, Messenger - genetics RNA, Messenger - metabolism Transcription Factors - genetics
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