Iodobenzene Catalyzed C–H Amination of N‑Substituted Amidines Using m‑Chloroperbenzoic Acid

The oxidative C–H amination of N″-aryl-N′-tosyl/N′-methylsulfonylamidines and N,N′-bis(aryl)amidines has been accomplished using iodobenzene as a catalyst to furnish 1,2-disubstituted benzimidazoles in the presence of mCPBA as a terminal oxidant at room temperature. The reaction is general, and the...

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Veröffentlicht in:	Organic letters 2013-03, Vol.15 (6), p.1334-1337
Hauptverfasser:	Alla, Santhosh Kumar, Kumar, Rapolu Kiran, Sadhu, Pradeep, Punniyamurthy, Tharmalingam
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidines - chemistry Amination Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Catalysis Chlorobenzoates - chemistry Combinatorial Chemistry Techniques Iodobenzenes - chemistry Molecular Structure Oxidation-Reduction Stereoisomerism
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container_title	Organic letters
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creator	Alla, Santhosh Kumar Kumar, Rapolu Kiran Sadhu, Pradeep Punniyamurthy, Tharmalingam
description	The oxidative C–H amination of N″-aryl-N′-tosyl/N′-methylsulfonylamidines and N,N′-bis(aryl)amidines has been accomplished using iodobenzene as a catalyst to furnish 1,2-disubstituted benzimidazoles in the presence of mCPBA as a terminal oxidant at room temperature. The reaction is general, and the target products can be obtained in moderate to high yields.
doi_str_mv	10.1021/ol400274f
format	Article
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subjects	Amidines - chemistry Amination Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Catalysis Chlorobenzoates - chemistry Combinatorial Chemistry Techniques Iodobenzenes - chemistry Molecular Structure Oxidation-Reduction Stereoisomerism
title	Iodobenzene Catalyzed C–H Amination of N‑Substituted Amidines Using m‑Chloroperbenzoic Acid
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