Mechanism of Retinoid X Receptor Partial Agonistic Action of 1‑(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)‑1H‑benzotriazole-5-carboxylic Acid and Structural Development To Increase Potency

We have reported that retinoid X receptor (RXR) partial agonist 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid (CBt-PMN, 4a) shows a significant antidiabetes effect in the KK-Ay type 2 diabetes model mice, with reduced side effects compared to RXR full ago...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-03, Vol.56 (5), p.1865-1877
Hauptverfasser:	Ohsawa, Fuminori, Yamada, Shoya, Yakushiji, Nobumasa, Shinozaki, Ryosuke, Nakayama, Mariko, Kawata, Kohei, Hagaya, Manabu, Kobayashi, Toshiki, Kohara, Kazutaka, Furusawa, Yuuki, Fujiwara, Chisa, Ohta, Yui, Makishima, Makoto, Naitou, Hirotaka, Tai, Akihiro, Yoshikawa, Yutaka, Yasui, Hiroyuki, Kakuta, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cercopithecus aethiops COS Cells Diabetes Mellitus, Type 2 - drug therapy Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Mice Models, Molecular Molecular Docking Simulation Retinoid X Receptors - agonists Retinoid X Receptors - drug effects Tetrahydronaphthalenes - chemistry Tetrahydronaphthalenes - pharmacology Triazoles - chemistry Triazoles - pharmacology
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