Efficacy of androgen deprivation therapy for localized prostate cancer: analysis of pT0 evaluated by radical prostatectomy specimen
In order to investigate which types of localized prostate cancer can be treated most effectively by androgen deprivation therapy (ADT), cases of no residual cancer in radical prostatectomy specimens (pT0) after neoadjuvant ADT were analyzed. Patients with localized prostate cancer who underwent radi...
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| Veröffentlicht in: | Anticancer research 2013-03, Vol.33 (3), p.1147-1151 |
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| creator | Kadono, Yoshifumi Yaegashi, Hiroshi Izumi, Kouji Ueno, Satoru Kitagawa, Yasuhide Mizokami, Atsushi Asahi, Hideki Kobashi, Kazunori Koshida, Kiyoshi Namiki, Mikio |
| description | In order to investigate which types of localized prostate cancer can be treated most effectively by androgen deprivation therapy (ADT), cases of no residual cancer in radical prostatectomy specimens (pT0) after neoadjuvant ADT were analyzed.
Patients with localized prostate cancer who underwent radical prostatectomy after neoadjuvant ADT were investigated retrospectively.
Thirty-two patients (24.2%) were diagnosed with pT0 disease by pathological evaluation. The positive-core proportion of prostate biopsy was lower, the duration of neoadjuvant ADT was longer, and prostate-specific antigen (PSA) nadir before radical prostatectomy was lower in pT0 cases compared to non-pT0 cases, and these differences were statistically significant. The percentage of pT0 cases with PSA nadir |
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Patients with localized prostate cancer who underwent radical prostatectomy after neoadjuvant ADT were investigated retrospectively.
Thirty-two patients (24.2%) were diagnosed with pT0 disease by pathological evaluation. The positive-core proportion of prostate biopsy was lower, the duration of neoadjuvant ADT was longer, and prostate-specific antigen (PSA) nadir before radical prostatectomy was lower in pT0 cases compared to non-pT0 cases, and these differences were statistically significant. The percentage of pT0 cases with PSA nadir <0.2 ng/ml and <0.008 ng/ml before radical prostatectomy were 29.2% (21 out of 72 cases) and 83.3% (5 out of 6 cases), respectively. The positive-core proportion of prostate biopsy and PSA nadir before radical prostatectomy had a significant impact on pT0 status after neoadjuvant ADT.
ADT for localized prostate cancer is thought to be highly effective in cases with low cancer volume. ADT is effective in cases of localized prostate cancer with PSA below the levels of detection by supersensitive PSA assay, and such cases show no cancer recurrence. Treatment options in such cases include intermittent or discontinuation of ADT.</description><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 23482794</identifier><language>eng</language><publisher>Greece</publisher><subject>Aged ; Androgen Antagonists - therapeutic use ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm, Residual ; Prostate-Specific Antigen - blood ; Prostatectomy ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - drug therapy ; Prostatic Neoplasms - pathology ; Retrospective Studies</subject><ispartof>Anticancer research, 2013-03, Vol.33 (3), p.1147-1151</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23482794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kadono, Yoshifumi</creatorcontrib><creatorcontrib>Yaegashi, Hiroshi</creatorcontrib><creatorcontrib>Izumi, Kouji</creatorcontrib><creatorcontrib>Ueno, Satoru</creatorcontrib><creatorcontrib>Kitagawa, Yasuhide</creatorcontrib><creatorcontrib>Mizokami, Atsushi</creatorcontrib><creatorcontrib>Asahi, Hideki</creatorcontrib><creatorcontrib>Kobashi, Kazunori</creatorcontrib><creatorcontrib>Koshida, Kiyoshi</creatorcontrib><creatorcontrib>Namiki, Mikio</creatorcontrib><title>Efficacy of androgen deprivation therapy for localized prostate cancer: analysis of pT0 evaluated by radical prostatectomy specimen</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>In order to investigate which types of localized prostate cancer can be treated most effectively by androgen deprivation therapy (ADT), cases of no residual cancer in radical prostatectomy specimens (pT0) after neoadjuvant ADT were analyzed.
Patients with localized prostate cancer who underwent radical prostatectomy after neoadjuvant ADT were investigated retrospectively.
Thirty-two patients (24.2%) were diagnosed with pT0 disease by pathological evaluation. The positive-core proportion of prostate biopsy was lower, the duration of neoadjuvant ADT was longer, and prostate-specific antigen (PSA) nadir before radical prostatectomy was lower in pT0 cases compared to non-pT0 cases, and these differences were statistically significant. The percentage of pT0 cases with PSA nadir <0.2 ng/ml and <0.008 ng/ml before radical prostatectomy were 29.2% (21 out of 72 cases) and 83.3% (5 out of 6 cases), respectively. The positive-core proportion of prostate biopsy and PSA nadir before radical prostatectomy had a significant impact on pT0 status after neoadjuvant ADT.
ADT for localized prostate cancer is thought to be highly effective in cases with low cancer volume. ADT is effective in cases of localized prostate cancer with PSA below the levels of detection by supersensitive PSA assay, and such cases show no cancer recurrence. Treatment options in such cases include intermittent or discontinuation of ADT.</description><subject>Aged</subject><subject>Androgen Antagonists - therapeutic use</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm, Residual</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatectomy</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Retrospective Studies</subject><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE9LxDAUxIsg7rr6FSRHL4WmSZvUmyzrH1jwsvfymrxoJG1qki7Uq1_ciquH4V1-M2-Ys2xNRUNzUbFilV3G-F4Udd1IdpGtSsZlKRq-zr52xlgFaibeEBh08K84EI1jsEdI1g8kvWGAcSbGB-K8Amc_UZMx-JggIVEwKAx3ixfcHG38yRkPBcEjuGkBNOlmEkAvT9y_SyXfzySOqGyPw1V2bsBFvD7dTXZ42B22T_n-5fF5e7_Px5LSlDeC044BZ2UnDDWilpzK0lCESgmOKKFbpI02NWpR1UpWtew6bpRgDS3ZJrv9jV1afEwYU9vbqNA5GNBPsaWMCl40NZMLenNCp65H3S5r9BDm9m839g2ek2v3</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Kadono, Yoshifumi</creator><creator>Yaegashi, Hiroshi</creator><creator>Izumi, Kouji</creator><creator>Ueno, Satoru</creator><creator>Kitagawa, Yasuhide</creator><creator>Mizokami, Atsushi</creator><creator>Asahi, Hideki</creator><creator>Kobashi, Kazunori</creator><creator>Koshida, Kiyoshi</creator><creator>Namiki, Mikio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201303</creationdate><title>Efficacy of androgen deprivation therapy for localized prostate cancer: analysis of pT0 evaluated by radical prostatectomy specimen</title><author>Kadono, Yoshifumi ; Yaegashi, Hiroshi ; Izumi, Kouji ; Ueno, Satoru ; Kitagawa, Yasuhide ; Mizokami, Atsushi ; Asahi, Hideki ; Kobashi, Kazunori ; Koshida, Kiyoshi ; Namiki, Mikio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-9741b3a432b7f1f7684182f1ea5c74ee8abe8adfdf6ed756c8568bb4fc739123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Androgen Antagonists - therapeutic use</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm, Residual</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatectomy</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kadono, Yoshifumi</creatorcontrib><creatorcontrib>Yaegashi, Hiroshi</creatorcontrib><creatorcontrib>Izumi, Kouji</creatorcontrib><creatorcontrib>Ueno, Satoru</creatorcontrib><creatorcontrib>Kitagawa, Yasuhide</creatorcontrib><creatorcontrib>Mizokami, Atsushi</creatorcontrib><creatorcontrib>Asahi, Hideki</creatorcontrib><creatorcontrib>Kobashi, Kazunori</creatorcontrib><creatorcontrib>Koshida, Kiyoshi</creatorcontrib><creatorcontrib>Namiki, Mikio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kadono, Yoshifumi</au><au>Yaegashi, Hiroshi</au><au>Izumi, Kouji</au><au>Ueno, Satoru</au><au>Kitagawa, Yasuhide</au><au>Mizokami, Atsushi</au><au>Asahi, Hideki</au><au>Kobashi, Kazunori</au><au>Koshida, Kiyoshi</au><au>Namiki, Mikio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of androgen deprivation therapy for localized prostate cancer: analysis of pT0 evaluated by radical prostatectomy specimen</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2013-03</date><risdate>2013</risdate><volume>33</volume><issue>3</issue><spage>1147</spage><epage>1151</epage><pages>1147-1151</pages><eissn>1791-7530</eissn><abstract>In order to investigate which types of localized prostate cancer can be treated most effectively by androgen deprivation therapy (ADT), cases of no residual cancer in radical prostatectomy specimens (pT0) after neoadjuvant ADT were analyzed.
Patients with localized prostate cancer who underwent radical prostatectomy after neoadjuvant ADT were investigated retrospectively.
Thirty-two patients (24.2%) were diagnosed with pT0 disease by pathological evaluation. The positive-core proportion of prostate biopsy was lower, the duration of neoadjuvant ADT was longer, and prostate-specific antigen (PSA) nadir before radical prostatectomy was lower in pT0 cases compared to non-pT0 cases, and these differences were statistically significant. The percentage of pT0 cases with PSA nadir <0.2 ng/ml and <0.008 ng/ml before radical prostatectomy were 29.2% (21 out of 72 cases) and 83.3% (5 out of 6 cases), respectively. The positive-core proportion of prostate biopsy and PSA nadir before radical prostatectomy had a significant impact on pT0 status after neoadjuvant ADT.
ADT for localized prostate cancer is thought to be highly effective in cases with low cancer volume. ADT is effective in cases of localized prostate cancer with PSA below the levels of detection by supersensitive PSA assay, and such cases show no cancer recurrence. Treatment options in such cases include intermittent or discontinuation of ADT.</abstract><cop>Greece</cop><pmid>23482794</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Anticancer research, 2013-03, Vol.33 (3), p.1147-1151 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aged Androgen Antagonists - therapeutic use Humans Male Middle Aged Neoplasm Grading Neoplasm, Residual Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - blood Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Retrospective Studies |
| title | Efficacy of androgen deprivation therapy for localized prostate cancer: analysis of pT0 evaluated by radical prostatectomy specimen |
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