Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio
The aim of this study was to compare the acute toxicity of acetylsalicylic acid to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio), oxidative stress parameters and detoxifying enzyme. Tests were performed according to OECD No. 203 (Fish, acute toxicity test) and OECD No. 212...
Gespeichert in:
| Veröffentlicht in: | Neuro-endocrinology letters 2012, Vol.33 Suppl 3, p.72-76 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 76 |
|---|---|
| container_issue | |
| container_start_page | 72 |
| container_title | Neuro-endocrinology letters |
| container_volume | 33 Suppl 3 |
| creator | Praskova, Eva Zivna, Dana Stepanova, Stanislava Sevcikova, Marie Blahova, Jana Marsalek, Petr Siroka, Zuzana Voslarova, Eva Svobodova, Zdenka |
| description | The aim of this study was to compare the acute toxicity of acetylsalicylic acid to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio), oxidative stress parameters and detoxifying enzyme.
Tests were performed according to OECD No. 203 (Fish, acute toxicity test) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages) methodology.
The results showed the mean acetylsalicylic acid LC50 value to be 567.7 mg/L in juvenile zebrafish. The acute toxicity of acetylsalicylic acid for zebrafish embryos was 274.6 mg/L. Statistically significantly higher activity of GST was found in concentrations 340, 380 and 420 mg/L of acetylsalicylic acid. TBARS, GPx and GST didn't show statistically significant activity in tested concentrations of acetylsalicylic acid.
The results revealed a statistically significantly higher degree of sensitivity in the embryonic stages of zebrafish compared to its juveniles. Acetylsalicylic acid did not cause statistically significantly higher antioxidative defence in zebrafish. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1317409017</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1317409017</sourcerecordid><originalsourceid>FETCH-LOGICAL-p211t-7f1dc57bd5220f9153495454f9020668c3eb9e6fc439aeb7760f3add516f793e3</originalsourceid><addsrcrecordid>eNo1kE1LxDAQhnNQ3HX1L0iOXgr5aJrmuKxfCwteVLyVNJlIlrapSSr231txPQwvw_vMHJ4ztCZUskLW5H2FLlM6EsKUYPwCrRjngtelXKO3rZky4By-vfF5xsFhbSDPXdKdN_Myy-7tAuDj9AWD7wDrwWLo2ziHYalT1h-Qfg_v9OADjhB9uELnTncJrk-5Qa8P9y-7p-Lw_LjfbQ_FyCjNhXTUGiFbKxgjTlHBSyVKUTpFGKmq2nBoFVTOlFxpaKWsiOPaWkErJxUHvkG3f3_HGD4nSLnpfTLQdXqAMKWGcipLohYRC3pzQqe2B9uM0fc6zs2_C_4DDxRaBg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1317409017</pqid></control><display><type>article</type><title>Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Praskova, Eva ; Zivna, Dana ; Stepanova, Stanislava ; Sevcikova, Marie ; Blahova, Jana ; Marsalek, Petr ; Siroka, Zuzana ; Voslarova, Eva ; Svobodova, Zdenka</creator><creatorcontrib>Praskova, Eva ; Zivna, Dana ; Stepanova, Stanislava ; Sevcikova, Marie ; Blahova, Jana ; Marsalek, Petr ; Siroka, Zuzana ; Voslarova, Eva ; Svobodova, Zdenka</creatorcontrib><description>The aim of this study was to compare the acute toxicity of acetylsalicylic acid to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio), oxidative stress parameters and detoxifying enzyme.
Tests were performed according to OECD No. 203 (Fish, acute toxicity test) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages) methodology.
The results showed the mean acetylsalicylic acid LC50 value to be 567.7 mg/L in juvenile zebrafish. The acute toxicity of acetylsalicylic acid for zebrafish embryos was 274.6 mg/L. Statistically significantly higher activity of GST was found in concentrations 340, 380 and 420 mg/L of acetylsalicylic acid. TBARS, GPx and GST didn't show statistically significant activity in tested concentrations of acetylsalicylic acid.
The results revealed a statistically significantly higher degree of sensitivity in the embryonic stages of zebrafish compared to its juveniles. Acetylsalicylic acid did not cause statistically significantly higher antioxidative defence in zebrafish.</description><identifier>ISSN: 0172-780X</identifier><identifier>PMID: 23353847</identifier><language>eng</language><publisher>Sweden</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - toxicity ; Aspirin - toxicity ; Dose-Response Relationship, Drug ; Embryo, Nonmammalian - drug effects ; Inactivation, Metabolic - physiology ; Lethal Dose 50 ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; Toxicity Tests, Acute ; Water Pollutants, Chemical - toxicity ; Water Quality ; Zebrafish - embryology</subject><ispartof>Neuro-endocrinology letters, 2012, Vol.33 Suppl 3, p.72-76</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23353847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Praskova, Eva</creatorcontrib><creatorcontrib>Zivna, Dana</creatorcontrib><creatorcontrib>Stepanova, Stanislava</creatorcontrib><creatorcontrib>Sevcikova, Marie</creatorcontrib><creatorcontrib>Blahova, Jana</creatorcontrib><creatorcontrib>Marsalek, Petr</creatorcontrib><creatorcontrib>Siroka, Zuzana</creatorcontrib><creatorcontrib>Voslarova, Eva</creatorcontrib><creatorcontrib>Svobodova, Zdenka</creatorcontrib><title>Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio</title><title>Neuro-endocrinology letters</title><addtitle>Neuro Endocrinol Lett</addtitle><description>The aim of this study was to compare the acute toxicity of acetylsalicylic acid to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio), oxidative stress parameters and detoxifying enzyme.
Tests were performed according to OECD No. 203 (Fish, acute toxicity test) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages) methodology.
The results showed the mean acetylsalicylic acid LC50 value to be 567.7 mg/L in juvenile zebrafish. The acute toxicity of acetylsalicylic acid for zebrafish embryos was 274.6 mg/L. Statistically significantly higher activity of GST was found in concentrations 340, 380 and 420 mg/L of acetylsalicylic acid. TBARS, GPx and GST didn't show statistically significant activity in tested concentrations of acetylsalicylic acid.
The results revealed a statistically significantly higher degree of sensitivity in the embryonic stages of zebrafish compared to its juveniles. Acetylsalicylic acid did not cause statistically significantly higher antioxidative defence in zebrafish.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - toxicity</subject><subject>Aspirin - toxicity</subject><subject>Dose-Response Relationship, Drug</subject><subject>Embryo, Nonmammalian - drug effects</subject><subject>Inactivation, Metabolic - physiology</subject><subject>Lethal Dose 50</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>Toxicity Tests, Acute</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water Quality</subject><subject>Zebrafish - embryology</subject><issn>0172-780X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LxDAQhnNQ3HX1L0iOXgr5aJrmuKxfCwteVLyVNJlIlrapSSr231txPQwvw_vMHJ4ztCZUskLW5H2FLlM6EsKUYPwCrRjngtelXKO3rZky4By-vfF5xsFhbSDPXdKdN_Myy-7tAuDj9AWD7wDrwWLo2ziHYalT1h-Qfg_v9OADjhB9uELnTncJrk-5Qa8P9y-7p-Lw_LjfbQ_FyCjNhXTUGiFbKxgjTlHBSyVKUTpFGKmq2nBoFVTOlFxpaKWsiOPaWkErJxUHvkG3f3_HGD4nSLnpfTLQdXqAMKWGcipLohYRC3pzQqe2B9uM0fc6zs2_C_4DDxRaBg</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Praskova, Eva</creator><creator>Zivna, Dana</creator><creator>Stepanova, Stanislava</creator><creator>Sevcikova, Marie</creator><creator>Blahova, Jana</creator><creator>Marsalek, Petr</creator><creator>Siroka, Zuzana</creator><creator>Voslarova, Eva</creator><creator>Svobodova, Zdenka</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio</title><author>Praskova, Eva ; Zivna, Dana ; Stepanova, Stanislava ; Sevcikova, Marie ; Blahova, Jana ; Marsalek, Petr ; Siroka, Zuzana ; Voslarova, Eva ; Svobodova, Zdenka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-7f1dc57bd5220f9153495454f9020668c3eb9e6fc439aeb7760f3add516f793e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - toxicity</topic><topic>Aspirin - toxicity</topic><topic>Dose-Response Relationship, Drug</topic><topic>Embryo, Nonmammalian - drug effects</topic><topic>Inactivation, Metabolic - physiology</topic><topic>Lethal Dose 50</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>Toxicity Tests, Acute</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Water Quality</topic><topic>Zebrafish - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Praskova, Eva</creatorcontrib><creatorcontrib>Zivna, Dana</creatorcontrib><creatorcontrib>Stepanova, Stanislava</creatorcontrib><creatorcontrib>Sevcikova, Marie</creatorcontrib><creatorcontrib>Blahova, Jana</creatorcontrib><creatorcontrib>Marsalek, Petr</creatorcontrib><creatorcontrib>Siroka, Zuzana</creatorcontrib><creatorcontrib>Voslarova, Eva</creatorcontrib><creatorcontrib>Svobodova, Zdenka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Neuro-endocrinology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Praskova, Eva</au><au>Zivna, Dana</au><au>Stepanova, Stanislava</au><au>Sevcikova, Marie</au><au>Blahova, Jana</au><au>Marsalek, Petr</au><au>Siroka, Zuzana</au><au>Voslarova, Eva</au><au>Svobodova, Zdenka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio</atitle><jtitle>Neuro-endocrinology letters</jtitle><addtitle>Neuro Endocrinol Lett</addtitle><date>2012</date><risdate>2012</risdate><volume>33 Suppl 3</volume><spage>72</spage><epage>76</epage><pages>72-76</pages><issn>0172-780X</issn><abstract>The aim of this study was to compare the acute toxicity of acetylsalicylic acid to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio), oxidative stress parameters and detoxifying enzyme.
Tests were performed according to OECD No. 203 (Fish, acute toxicity test) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages) methodology.
The results showed the mean acetylsalicylic acid LC50 value to be 567.7 mg/L in juvenile zebrafish. The acute toxicity of acetylsalicylic acid for zebrafish embryos was 274.6 mg/L. Statistically significantly higher activity of GST was found in concentrations 340, 380 and 420 mg/L of acetylsalicylic acid. TBARS, GPx and GST didn't show statistically significant activity in tested concentrations of acetylsalicylic acid.
The results revealed a statistically significantly higher degree of sensitivity in the embryonic stages of zebrafish compared to its juveniles. Acetylsalicylic acid did not cause statistically significantly higher antioxidative defence in zebrafish.</abstract><cop>Sweden</cop><pmid>23353847</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0172-780X |
| ispartof | Neuro-endocrinology letters, 2012, Vol.33 Suppl 3, p.72-76 |
| issn | 0172-780X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1317409017 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - toxicity Aspirin - toxicity Dose-Response Relationship, Drug Embryo, Nonmammalian - drug effects Inactivation, Metabolic - physiology Lethal Dose 50 Oxidative Stress - drug effects Oxidative Stress - physiology Toxicity Tests, Acute Water Pollutants, Chemical - toxicity Water Quality Zebrafish - embryology |
| title | Acute toxicity of acetylsalicylic acid to juvenile and embryonic stages of Danio rerio |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T00%3A58%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20toxicity%20of%20acetylsalicylic%20acid%20to%20juvenile%20and%20embryonic%20stages%20of%20Danio%20rerio&rft.jtitle=Neuro-endocrinology%20letters&rft.au=Praskova,%20Eva&rft.date=2012&rft.volume=33%20Suppl%203&rft.spage=72&rft.epage=76&rft.pages=72-76&rft.issn=0172-780X&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1317409017%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1317409017&rft_id=info:pmid/23353847&rfr_iscdi=true |