CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

Targeted deletion of the chemokine Cxcl12 in different bone marrow stromal cell populations shows that distinct niches exist in the bone marrow for haematopoietic stem cells and lineage-committed progenitors. Multiple stem cell niches in bone marrow The chemokine CXCL12 has an important role in main...

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Veröffentlicht in:	Nature (London) 2013-03, Vol.495 (7440), p.227-230
Hauptverfasser:	Greenbaum, Adam, Hsu, Yen-Michael S., Day, Ryan B., Schuettpelz, Laura G., Christopher, Matthew J., Borgerding, Joshua N., Nagasawa, Takashi, Link, Daniel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/2139 Animals B-Lymphocytes - cytology Bone marrow Bone Marrow - metabolism Cell Movement Chemokine CXCL2 - deficiency Chemokine CXCL2 - genetics Chemokine CXCL2 - metabolism Chemokines Genetic code Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humanities and Social Sciences Intermediate Filament Proteins - deficiency letter Ligand binding (Biochemistry) Ligands (Biochemistry) Lymphoid Progenitor Cells - cytology Lymphoid Progenitor Cells - metabolism Medical research Medicine, Experimental Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Mice multidisciplinary Nerve Tissue Proteins - deficiency Nestin Physiological aspects Population Receptor, Platelet-Derived Growth Factor alpha - genetics Receptor, Platelet-Derived Growth Factor alpha - metabolism Rodents Science Stem Cell Niche - physiology Stem cells
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