Mitochondrial dysfunction and the inflammatory response

Mitochondrial dysfunction and the inflammatory response

Inflammation has been linked to multiple degenerative and acute diseases as well as the aging process. Moreover, mitochondrial alterations play a central role in these processes. Mitochondria have an important role in pro-inflammatory signaling; similarly, pro-inflammatory mediators may also alter m...

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Veröffentlicht in:Mitochondrion 2013-03, Vol.13 (2), p.106-118
Hauptverfasser: López-Armada, María J, Riveiro-Naveira, Romina R, Vaamonde-García, Carlos, Valcárcel-Ares, Marta N
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Sprache:eng
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Humans
Inflammation - pathology
Mitochondria - metabolism
Mitochondria - physiology
Oxidative Stress
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container_end_page 118
container_issue 2
container_start_page 106
container_title Mitochondrion
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creator López-Armada, María J
Riveiro-Naveira, Romina R
Vaamonde-García, Carlos
Valcárcel-Ares, Marta N
description Inflammation has been linked to multiple degenerative and acute diseases as well as the aging process. Moreover, mitochondrial alterations play a central role in these processes. Mitochondria have an important role in pro-inflammatory signaling; similarly, pro-inflammatory mediators may also alter mitochondrial function. Both of these processes increase mitochondrial oxidative stress, promoting a vicious inflammatory cycle. Additionally, damage-associated molecular patterns derived from mitochondria could contribute to inflammasome formation and caspase-1 activation, while alterations in mitochondrial autophagy may cause inflammation. Strategies aimed at controlling excessive oxidative stress within mitochondria may represent both preventive and therapeutic interventions in inflammation.
doi_str_mv 10.1016/j.mito.2013.01.003
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subjects Humans
Inflammation - pathology
Mitochondria - metabolism
Mitochondria - physiology
Oxidative Stress
title Mitochondrial dysfunction and the inflammatory response
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