Peginesatide clearance, distribution, metabolism, and excretion in monkeys following intravenous administration

Peginesatide, a polyethylene glycol (PEG)ylated peptide-based erythropoiesis-stimulating agent, stimulates the erythropoietin receptor dimer that governs erythropoiesis. Studies were designed to determine the erythropoietic response, pharmacokinetics (PK), tissue distribution, metabolism, and excret...

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Veröffentlicht in:	Drug metabolism and disposition 2013-04, Vol.41 (4), p.774-784
Hauptverfasser:	Woodburn, Kathryn W, Fong, Kei-Lai, Wilson, Susan D, Sloneker, Steven, Strzemienski, Paul, Solon, Eric, Moriya, Yuu, Tagawa, Yoshihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Animals Biological Availability Bone Marrow - diagnostic imaging Bone Marrow - metabolism Dose-Response Relationship, Drug Erythropoiesis - drug effects Hematinics - administration & dosage Hematinics - metabolism Hematinics - pharmacokinetics Hematinics - pharmacology Kidney - diagnostic imaging Kidney - metabolism Macaca fascicularis Male Peptides - administration & dosage Peptides - metabolism Peptides - pharmacokinetics Peptides - pharmacology Radionuclide Imaging Spleen - diagnostic imaging Spleen - metabolism
Online-Zugang:	Volltext
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