Ex vivo characterization of γδ T-cell repertoire in patients after adoptive transfer of Vγ9Vδ2 T cells expressing the interleukin-2 receptor β-chain and the common γ-chain

Abstract Background aims Adoptive immunotherapy is emerging as a potent anti-tumor treatment modality; Vγ9Vδ2 T cells may represent appropriate agents for such cancer immunotherapy. To improve the currently limited success of Vγ9Vδ2 T-cell–based immunotherapy, we examined the in vivo dynamics of the...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2013-04, Vol.15 (4), p.481-491
Hauptverfasser:	Izumi, Takamichi, Kondo, Makoto, Takahashi, Takuya, Fujieda, Nao, Kondo, Atsushi, Tamura, Naohisa, Murakawa, Tomohiro, Nakajima, Jun, Matsushita, Hirokazu, Kakimi, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	adoptive transfer Advanced Basic Science Aged Aged, 80 and over Cell Proliferation Colorectal Neoplasms - immunology Colorectal Neoplasms - therapy common γ-chain cytokine Diphosphonates - pharmacology Female Humans IL-15 IL-7 Imidazoles - pharmacology Immunotherapy, Adoptive - methods Interleukin Receptor Common gamma Subunit - biosynthesis Interleukin Receptor Common gamma Subunit - immunology Interleukin-15 - immunology Interleukin-2 - pharmacology Interleukin-2 Receptor beta Subunit - biosynthesis Interleukin-2 Receptor beta Subunit - immunology Leukocytes, Mononuclear - drug effects Lymphocyte Activation Male Middle Aged Other Receptors, Antigen, T-Cell, gamma-delta - immunology Receptors, Antigen, T-Cell, gamma-delta - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - transplantation Vγ9Vδ2 T cell
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