Aqueous extract of unripe Rubus coreanus fruit attenuates atherosclerosis by improving blood lipid profile and inhibiting NF-κB activation via phase II gene expression

The fruit of Rubus coreanus has been used as a traditional herbal medicine for alleviation of inflammatory and vascular diseases in Asian countries. The anti-atherogenic effect of unripe Rubus coreanus fruit extract (URFE) and its underlying mechanism were analyzed in mice fed a high-fat diet (HFD)...

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Veröffentlicht in:	Journal of ethnopharmacology 2013-03, Vol.146 (2), p.515-524
Hauptverfasser:	Kim, Sookon, Kim, Chun-Ki, Lee, Kwang-Soon, Kim, Ji-Hee, Hwang, Haejun, Jeoung, Dooil, Choe, Jongseon, Won, Moo-Ho, Lee, Hansoo, Ha, Kwon-Soo, Kwon, Young-Geun, Kim, Young-Myeong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - metabolism Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - genetics Atherosclerosis - metabolism Cell Line Cholesterol - blood Fruit Gene Expression Regulation - drug effects Glutamate-Cysteine Ligase - genetics Heme Oxygenase-1 - genetics Homeodomain Proteins - genetics Inflammation Interleukin-1beta - metabolism Lipid profile Male Membrane Proteins - genetics Mice Mice, Inbred C57BL NF-E2-Related Factor 2 - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Nitric Oxide Synthase Type II - metabolism Phase II gene Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Rosaceae Rubus coreanus fruit Tumor Necrosis Factor-alpha - metabolism
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