Simultaneous electrochemical determination of guanosine and adenosine with graphene–ZrO2 nanocomposite modified carbon ionic liquid electrode
In this paper an ionic liquid 1-hexylpyridinium hexafluorophosphate based carbon ionic liquid electrode (CILE) was fabricated and used as the basal electrode, which was further modified by graphene (GR) and ZrO2 nanoparticle with chitosan (CTS) film to immobilize the nanocomposite. The modified elec...
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| Veröffentlicht in: | Biosensors & bioelectronics 2013-06, Vol.44, p.146-151 |
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| creator | Sun, Wei Wang, Xiuzhen Sun, Xiaohuan Deng, Ying Liu, Jun Lei, Bingxin Sun, Zhenfan |
| description | In this paper an ionic liquid 1-hexylpyridinium hexafluorophosphate based carbon ionic liquid electrode (CILE) was fabricated and used as the basal electrode, which was further modified by graphene (GR) and ZrO2 nanoparticle with chitosan (CTS) film to immobilize the nanocomposite. The modified electrode was denoted as CTS–GR–ZrO2/CILE and further used for the simultaneous detection of adenosine and guanosine. Electrochemical performances of the modified electrode were greatly enhanced due to the presence of GR–ZrO2 nanocomposite, and the direct electro-oxidation behaviors of adenosine and guanosine were carefully investigated. Both adenosine and guanosine exhibited an increase of the oxidation peak currents with the negative shift of the oxidation peak potentials on the modified electrode, which indicated the electrocatalytic activity of GR–ZrO2 nanocomposite on the electrode surface. Electrochemical parameters of adenosine and guanosine on CTS–GR–ZrO2/CILE were calculated respectively, and a new electroanalytical method for the simultaneous determination of adenosine and guanosine was further established with the peak-to-peak separation (ΔEp) as 0.225V. The proposed method was successfully applied to detect adenosine and guanosine in human urine samples with satisfactory results.
► Graphene and ZrO2 nanoparticles based nanocomposite were used for the electrode modification. ► Adenosine and guanosine were simultaneous detected by the modified electrode. ► The proposed method was applied to the human urine samples with satisfactory results. |
| doi_str_mv | 10.1016/j.bios.2013.01.030 |
| format | Article |
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► Graphene and ZrO2 nanoparticles based nanocomposite were used for the electrode modification. ► Adenosine and guanosine were simultaneous detected by the modified electrode. ► The proposed method was applied to the human urine samples with satisfactory results.</description><identifier>ISSN: 0956-5663</identifier><identifier>EISSN: 1873-4235</identifier><identifier>DOI: 10.1016/j.bios.2013.01.030</identifier><identifier>PMID: 23416316</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Adenosine ; Adenosine - urine ; Biological and medical sciences ; Biotechnology ; Carbon - chemistry ; Carbon ionic liquid electrode ; Electrochemical Techniques - instrumentation ; Electrodes ; Fundamental and applied biological sciences. Psychology ; Graphene ; Graphite - chemistry ; Guanosine ; Guanosine - urine ; Humans ; Ionic Liquids - chemistry ; Nanocomposites - chemistry ; Nanocomposites - ultrastructure ; Sensitivity and Specificity ; Zirconium - chemistry ; ZrO2 nanoparticle</subject><ispartof>Biosensors & bioelectronics, 2013-06, Vol.44, p.146-151</ispartof><rights>2013 Elsevier B.V.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-6c62c1fa917454b736ff8414f3d6f7539ef4d4e21ec0a25fc3ae2982ad76b2b13</citedby><cites>FETCH-LOGICAL-c386t-6c62c1fa917454b736ff8414f3d6f7539ef4d4e21ec0a25fc3ae2982ad76b2b13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bios.2013.01.030$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27145815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23416316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Wei</creatorcontrib><creatorcontrib>Wang, Xiuzhen</creatorcontrib><creatorcontrib>Sun, Xiaohuan</creatorcontrib><creatorcontrib>Deng, Ying</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Lei, Bingxin</creatorcontrib><creatorcontrib>Sun, Zhenfan</creatorcontrib><title>Simultaneous electrochemical determination of guanosine and adenosine with graphene–ZrO2 nanocomposite modified carbon ionic liquid electrode</title><title>Biosensors & bioelectronics</title><addtitle>Biosens Bioelectron</addtitle><description>In this paper an ionic liquid 1-hexylpyridinium hexafluorophosphate based carbon ionic liquid electrode (CILE) was fabricated and used as the basal electrode, which was further modified by graphene (GR) and ZrO2 nanoparticle with chitosan (CTS) film to immobilize the nanocomposite. The modified electrode was denoted as CTS–GR–ZrO2/CILE and further used for the simultaneous detection of adenosine and guanosine. Electrochemical performances of the modified electrode were greatly enhanced due to the presence of GR–ZrO2 nanocomposite, and the direct electro-oxidation behaviors of adenosine and guanosine were carefully investigated. Both adenosine and guanosine exhibited an increase of the oxidation peak currents with the negative shift of the oxidation peak potentials on the modified electrode, which indicated the electrocatalytic activity of GR–ZrO2 nanocomposite on the electrode surface. Electrochemical parameters of adenosine and guanosine on CTS–GR–ZrO2/CILE were calculated respectively, and a new electroanalytical method for the simultaneous determination of adenosine and guanosine was further established with the peak-to-peak separation (ΔEp) as 0.225V. The proposed method was successfully applied to detect adenosine and guanosine in human urine samples with satisfactory results.
► Graphene and ZrO2 nanoparticles based nanocomposite were used for the electrode modification. ► Adenosine and guanosine were simultaneous detected by the modified electrode. ► The proposed method was applied to the human urine samples with satisfactory results.</description><subject>Adenosine</subject><subject>Adenosine - urine</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Carbon - chemistry</subject><subject>Carbon ionic liquid electrode</subject><subject>Electrochemical Techniques - instrumentation</subject><subject>Electrodes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Graphene</subject><subject>Graphite - chemistry</subject><subject>Guanosine</subject><subject>Guanosine - urine</subject><subject>Humans</subject><subject>Ionic Liquids - chemistry</subject><subject>Nanocomposites - chemistry</subject><subject>Nanocomposites - ultrastructure</subject><subject>Sensitivity and Specificity</subject><subject>Zirconium - chemistry</subject><subject>ZrO2 nanoparticle</subject><issn>0956-5663</issn><issn>1873-4235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kbuO1DAUhi0EYoeFF6BAbpC2SfAlcRKJBq24SSttATQ0lmMf75xRYs_aCYhu34CCN-RJ8GhmoaOyjvSd_1jfT8hzzmrOuHq1q0eMuRaMy5rxmkn2gGx438mqEbJ9SDZsaFXVKiXPyJOcd4yxjg_sMTkTsuFKcrUhPz_hvE6LCRDXTGECu6RotzCjNRN1sECaMZgFY6DR05vVhJgxADXBUePgNH3HZUtvktlvIcDvu19f07WgobA2zvuCLEDn6NAjOGpNGktaSURLJ7xd0d0fdvCUPPJmyvDs9J6TL-_efr78UF1dv_94-eaqsrJXS6WsEpZ7M_CuaZuxk8r7vuGNl075rpUD-MY1IDhYZkTrrTQghl4Y16lRjFyek4tj7j7F2xXyomfMFqbpaEJzWZKZUEIVVBxRm2LOCbzeJ5xN-qE504ci9E4fitCHIjTjuhRRll6c8tdxBvd35d58AV6eAJOLap9MsJj_cR1v2p63hXt95KDY-IaQdLYIwYLDVJxpF_F___gDLiircg</recordid><startdate>20130615</startdate><enddate>20130615</enddate><creator>Sun, Wei</creator><creator>Wang, Xiuzhen</creator><creator>Sun, Xiaohuan</creator><creator>Deng, Ying</creator><creator>Liu, Jun</creator><creator>Lei, Bingxin</creator><creator>Sun, Zhenfan</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130615</creationdate><title>Simultaneous electrochemical determination of guanosine and adenosine with graphene–ZrO2 nanocomposite modified carbon ionic liquid electrode</title><author>Sun, Wei ; Wang, Xiuzhen ; Sun, Xiaohuan ; Deng, Ying ; Liu, Jun ; Lei, Bingxin ; Sun, Zhenfan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-6c62c1fa917454b736ff8414f3d6f7539ef4d4e21ec0a25fc3ae2982ad76b2b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adenosine</topic><topic>Adenosine - urine</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Carbon - chemistry</topic><topic>Carbon ionic liquid electrode</topic><topic>Electrochemical Techniques - instrumentation</topic><topic>Electrodes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Graphene</topic><topic>Graphite - chemistry</topic><topic>Guanosine</topic><topic>Guanosine - urine</topic><topic>Humans</topic><topic>Ionic Liquids - chemistry</topic><topic>Nanocomposites - chemistry</topic><topic>Nanocomposites - ultrastructure</topic><topic>Sensitivity and Specificity</topic><topic>Zirconium - chemistry</topic><topic>ZrO2 nanoparticle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Wei</creatorcontrib><creatorcontrib>Wang, Xiuzhen</creatorcontrib><creatorcontrib>Sun, Xiaohuan</creatorcontrib><creatorcontrib>Deng, Ying</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Lei, Bingxin</creatorcontrib><creatorcontrib>Sun, Zhenfan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biosensors & bioelectronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Wei</au><au>Wang, Xiuzhen</au><au>Sun, Xiaohuan</au><au>Deng, Ying</au><au>Liu, Jun</au><au>Lei, Bingxin</au><au>Sun, Zhenfan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous electrochemical determination of guanosine and adenosine with graphene–ZrO2 nanocomposite modified carbon ionic liquid electrode</atitle><jtitle>Biosensors & bioelectronics</jtitle><addtitle>Biosens Bioelectron</addtitle><date>2013-06-15</date><risdate>2013</risdate><volume>44</volume><spage>146</spage><epage>151</epage><pages>146-151</pages><issn>0956-5663</issn><eissn>1873-4235</eissn><abstract>In this paper an ionic liquid 1-hexylpyridinium hexafluorophosphate based carbon ionic liquid electrode (CILE) was fabricated and used as the basal electrode, which was further modified by graphene (GR) and ZrO2 nanoparticle with chitosan (CTS) film to immobilize the nanocomposite. The modified electrode was denoted as CTS–GR–ZrO2/CILE and further used for the simultaneous detection of adenosine and guanosine. Electrochemical performances of the modified electrode were greatly enhanced due to the presence of GR–ZrO2 nanocomposite, and the direct electro-oxidation behaviors of adenosine and guanosine were carefully investigated. Both adenosine and guanosine exhibited an increase of the oxidation peak currents with the negative shift of the oxidation peak potentials on the modified electrode, which indicated the electrocatalytic activity of GR–ZrO2 nanocomposite on the electrode surface. Electrochemical parameters of adenosine and guanosine on CTS–GR–ZrO2/CILE were calculated respectively, and a new electroanalytical method for the simultaneous determination of adenosine and guanosine was further established with the peak-to-peak separation (ΔEp) as 0.225V. The proposed method was successfully applied to detect adenosine and guanosine in human urine samples with satisfactory results.
► Graphene and ZrO2 nanoparticles based nanocomposite were used for the electrode modification. ► Adenosine and guanosine were simultaneous detected by the modified electrode. ► The proposed method was applied to the human urine samples with satisfactory results.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>23416316</pmid><doi>10.1016/j.bios.2013.01.030</doi><tpages>6</tpages></addata></record> |
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| subjects | Adenosine Adenosine - urine Biological and medical sciences Biotechnology Carbon - chemistry Carbon ionic liquid electrode Electrochemical Techniques - instrumentation Electrodes Fundamental and applied biological sciences. Psychology Graphene Graphite - chemistry Guanosine Guanosine - urine Humans Ionic Liquids - chemistry Nanocomposites - chemistry Nanocomposites - ultrastructure Sensitivity and Specificity Zirconium - chemistry ZrO2 nanoparticle |
| title | Simultaneous electrochemical determination of guanosine and adenosine with graphene–ZrO2 nanocomposite modified carbon ionic liquid electrode |
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